Publication: Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry
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Authors
Authors
De Luca G.
Algowhary M.
Uguz B.
Oliveira D. C.
Ganyukov V.
Zimbakov Z.
Cercek M.
Jensen L. O.
Loh P. H.
Calmac L.
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Abstract
The so-called \"smoking paradox\", conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history.
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Keywords
Tıp, Sağlık Bilimleri, Temel Tıp Bilimleri, Medicine, Health Sciences, Fundamental Medical Sciences, TIP, GENEL & DAHİLİ, Klinik Tıp, Klinik Tıp (MED), MEDICINE, GENERAL & INTERNAL, CLINICAL MEDICINE, Clinical Medicine (MED), Genel Sağlık Meslekleri, Patofizyoloji, Temel Bilgi ve Beceriler, Değerlendirme ve Teşhis, Dahiliye, Aile Sağlığı, Tıp (çeşitli), Genel Tıp, General Health Professions, Pathophysiology, Fundamentals and Skills, Assessment and Diagnosis, Internal Medicine, Family Practice, Medicine (miscellaneous), General Medicine, myocardial infarction, smoking paradox, percutaneous coronary intervention, COVID-19, ACUTE MYOCARDIAL-INFARCTION, CORONARY-ARTERY-DISEASE, ST-SEGMENT ELEVATION, CIGARETTE-SMOKING, THROMBOLYTIC THERAPY, CARDIOVASCULAR-DISEASE, OUTCOMES, EXTENT, SMOKERS, TIME
Citation
De Luca G., Algowhary M., Uguz B., Oliveira D. C., Ganyukov V., Zimbakov Z., Cercek M., Jensen L. O., Loh P. H., Calmac L., et al., "Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry", JOURNAL OF CLINICAL MEDICINE, cilt.11, sa.22, 2022