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YAMAÇ, AYLİN HATİCE

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AYLİN HATİCE

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YAMAÇ

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2013 - 2019142020 - 20224
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    Publication
    Evaluation of the Safety of Everolimus-Eluting Bioresorbable Vascular Scaffold (BVS) Implantation in Patients With Chronic Total Coronary Occlusions: Acute Procedural and Short-Term Clinical Results
    (2015-10-01T00:00:00Z) Goktekin, Omer; YAMAÇ, AYLİN HATİCE; Latib, Azeem; Tastan, Ahmet; Panoulas, Vasileios F.; Sato, Katsumasa; Erdogan, Ercan; Uyarel, Huseyin; Shah, Ibrahim; Colombo, Antonio; YAMAÇ, AYLİN HATİCE
    Aims. The bioresorbable vascular scaffold (BVS) (Abbott Vascular) provides temporary scaffolding while eluting everolimus. There are limited data on its use in daily practice, especially in patients with stable angina pectoris referred for elective percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs). The current study aims to investigate the safety and efficacy of BVS implantation in a selected patient cohort with CTO. Methods. A total of 70 consecutive patients, who underwent successful recanalization of CTO with BVS between September 13, 2012 and September 20, 2014 in three cardiac centers (Department of Cardiology, Bezmialem Vakif University, Istanbul, Turkey; Department of Interventional Cardiology, San Raffaele Hospital, Milan, Italy; and EMO-GVM Centro Cuore Columbus, Milan, Italy) were included in this CTO registry. Endpoints analyzed included: (1) the composite of all-cause death and non-fatal myocardial infarction (MI); and (2) the composite safety endpoint of major adverse cardiovascular events (MACEs), including death, MI and symptom-driven target lesion revascularization (TLR). Results. Clinical data were obtained for 70 patients (mean age, 56.9 +/- 9.4 years; 90.0% male) with a total number of 76 CTOs. At a median follow-up of 11.0 months (interquartile range, 7-18 months), both MACE and TLR rates were 4.3%. Two patients suffered from ischemia-driven TLR (1 patient at 6 months and 1 patient at 9 months after implantation). No death, MI, or stent thrombosis was observed during the follow-up period. Conclusion. Treatment of CTOs with BVS seems to be safe and effective, with a high technical success rate and acceptable MACE at short-term follow-up.
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    Publication
    Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery
    (2016-05-01T00:00:00Z) YAMAÇ, AYLİN HATİCE; Kucukbuzcu, Sitki; OZANSOY, MEHMET; Gok, Ozlem; Oz, Kursat; Erturk, Mehmet; Yilmaz, Emre; Ersoy, Burak; ZEYBEK, RAHMİ; Goktekin, Omer; Kilic, Ulkan; YAMAÇ, AYLİN HATİCE; ZEYBEK, RAHMİ
    Background: Postoperative atrial fibrillation (POAF) is a potentially life-threatening complication after coronary artery bypass graft (CABG) surgery. The expression of the cardioprotective SIRT1 protein with its antioxidant activity is increased in cardiac tissue of patients suffering from POAF. So far, information is lacking about the relationship between SIRT1 regulating micro RNAs (miRs), SIRT1 protein and the occurrence of POAF.
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    SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion
    (2022-10-01T00:00:00Z) De Luca, Giuseppe; Algowhary, Magdy; Uguz, Berat; Oliveira, Dinaldo C.; Ganyukov, Vladimir; Zimbakov, Zan; Cercek, Miha; Jensen, Lisette Okkels; Loh, Poay Huan; Calmac, Lucian; Ferrer, Gerard Roura; Quadros, Alexandre; Milewski, Marek; Di Uccio, Fortunato Scotto; von Birgelen, Clemens; Versaci, Francesco; Ten Berg, Jurrien; Casella, Gianni; Lung, Aaron Wong Sung; Kala, Petr; Gil, Jose Luis Diez; Carrillo, Xavier; Dirksen, Maurits; Becerra-Munoz, Victor M.; Lee, Michael Kang-Yin; Juzar, Dafsah Arifa; Joaquim, Rodrigo de Moura; De Simone, Ciro; Milicic, Davor; Davlouros, Periklis; Bakraceski, Nikola; Zilio, Filippo; Donazzan, Luca; Kraaijeveld, Adriaan; Galasso, Gennaro; Arpad, Lux; Marinucci, Lucia; Guiducci, Vincenzo; Menichelli, Maurizio; Scoccia, Alessandra; Yamac, Aylin Hatice; MERT, KADİR UĞUR; Rios, Xacobe Flores; Kovarnik, Tomas; Kidawa, Michal; Moreu, Jose; Flavien, Vincent; Fabris, Enrico; Martinez-Luengas, Inigo Lozano; Boccalatte, Marco; Ojeda, Francisco Bosa; Arellano-Serrano, Carlos; Caiazzo, Gianluca; Cirrincione, Giuseppe; Kao, Hsien-Li; Fores, Juan Sanchis; Vignali, Luigi; Pereira, Helder; Manzo-Silbermann, Stephane; Ordonez, Santiago; Ozkan, Alev Arat; Scheller, Bruno; Lehtola, Heidi; Teles, Rui; Mantis, Christos; Antti, Ylitalo; Silveira, Joao Antonio Brum; Bessonov, Ivan; Zoni, Rodrigo; Savonitto, Stefano; Kochiadakis, George; Alexopoulos, Dimitrios; Uribe, Carlos E.; Kanakakis, John; Faurie, Benjamin; Gabrielli, Gabriele; Barrios, Alejandro Gutierrez; Bachini, Juan Pablo; Rocha, Alex; Tam, Frankie Chor-Cheung; Rodriguez, Alfredo; Lukito, Antonia Anna; Bellemain-Appaix, Anne; Pessah, Gustavo; Cortese, Giuliana; Parodi, Guido; Burgadha, Mohammed Abed; Kedhi, Elvin; Lamelas, Pablo; Suryapranata, Harry; Nardin, Matteo; Verdoia, Monica; YAMAÇ, AYLİN HATİCE
    SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older (P = .002), less often active smokers (P = .002), and hypercholesterolemic (P = .006), they presented more often later than 12 h (P = .037), more often to the hub and were more often in cardiogenic shock (P = .02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P < .0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow (P = .029) and more thrombectomy (P = .046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P < .001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P < .001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P < .001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences.
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    Publication
    -Mitral klip vakasında, transseptal ponksiyon sırasında aortik iyatrojenik perforasyonun, amplatzer ductal occluder ile başarılı kapatılması-
    (2019-04-28T00:00:00Z) ENHOŞ, ASİM; KAHRAMAN AY, NURAY; ULUGANYAN, MAHMUT; BAKSHALİYEV, NİJAD; YAMAÇ, AYLİN HATİCE; ÇELİKKALE, İLKE; İSMAİLOĞLU, ZİYA; BACAKSIZ, AHMET; ÖZDEMİR, RAMAZAN; ENHOŞ, ASIM; KAHRAMAN AY, NURAY; ULUGANYAN, MAHMUT; YAMAÇ, AYLİN HATİCE; ÇELİKKALE, İLKE; BACAKSIZ, AHMET; ÖZDEMİR, RAMAZAN
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    Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI
    (2015-04-01) ERCAN, ÇİLEM; YAMAÇ, AYLİN HATİCE; YAMAÇ, AYLİN HATİCE; ERCAN, ÇİLEM; BACAKSIZ, AHMET
    Increased serum levels of the activated aspartic lysosomal endopeptidase cathepsin D (CatD) have been found in patients with acute myocardial infarction (AMI). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of post-MI heart failure. This study aimed to evaluate the role of serum CatD activity in the development of heart failure in patients with ST-segment elevation acute myocardial infarction (STEMI).
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    Utility of the Neutrophil to Lymphocyte Ratio in Predicting In-hospital Mortality in Patients That Received Levosimendan Treatment for Acute Decompensated Heart Failure
    (2013-10-01T00:00:00Z) Tasal, Abdurrahman; Surgit, Ozgur; BACAKSIZ, AHMET; Goktekin, Omer; Uyarel, Huseyin; Ergelen, Mehmet; Erdogan, Ercan; Kul, Seref; Sonmez, Osman; Turfan, Murat; Kucukbuzcu, Sitki; Vatankulu, Mehmet Akif; YAMAÇ, AYLİN HATİCE; BACAKSIZ, AHMET; YAMAÇ, AYLİN HATİCE
    Aim The aim of the study was to investigate the effect of levosimendan infusion on hematological variables in patients with acute heart failure. Also, predictive value of these variables over in hospital mortality evaluated. Methods Two hundred and nineteen patients (168 male, 51 female, mean age 63.2±12.7 years) with acute exerbation of advanced heart failure (ejection fraction ≤35%) were included in this study. Levosimendan was initiated as a bolus of 6 μg/kg followed by a continuous infusion of 0,1 μg/kg/min for 24 hours. Changes of hematological variables between admission and on third day after levosimendan infusion were evaluated. Categorical variables were expressed as frequencies and percentages. Continuous variables were compared using analysis of variance and Kruskal-Wallis tests for those with normal and skewed distributions, respectively. Chi-square tests were used to compare categorical variables. Univariate and multivariate Cox regression models were used to evaluate the independent association of different hematological variables with in-hospital mortality. Results Table 1 demonstrated the baseline demographical and laboratory characteristics of the patients. After levosimendan therapy, significant decrease in WBC and neutrophil counts and increase in lymphocyte count. As a result, neutrophil to lymphocyte ratio (NLR) decreased. Compared to patients that survived, in patients who died during in-hospital stay, these hematological changes not occurred ( Table 2 ). Δ NLR detected as independent predictor of in hospital mortality when other hematological variables associated with mortality analysed in the multivariate logistic regression analysis (R2=0.094, p=0.003). Conclusion Our study showed that levosimendan treatment is associated with significant changes in hematological variables in patients with acute exacerbation of advanced heart failure. The difference between baseline and post-treatment NLR is independent predictor of in hospital mortality.
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    MicroRNA 199a Is Downregulated in Patients After Coronary Artery Bypass Graft Surgery and Is Associated with Increased Levels of Sirtuin 1 (SIRT 1) Protein and Major Adverse Cardiovascular Events at 3-Year Follow-Up
    (2018-09-01T00:00:00Z) YAMAÇ, AYLİN HATİCE; Bakhshaliyev, Nijad; HUYUT, MUSTAFA AHMET; Yilmaz, Emre; ÇELİKKALE, İLKE; BACAKSIZ, AHMET; Demir, Yusuf; Demir, Ali Riza; Erturk, Mehmet; ÖZDEMİR, Ramazan; KILIÇ, ÜLKAN; YAMAÇ, AYLİN HATİCE; HUYUT, MUSTAFA AHMET; ÇELİKKALE, İLKE; BACAKSIZ, AHMET; BAKHSALIYEV, NIJAD; ÖZDEMİR, RAMAZAN
    Background: The cardioprotective protein SIRT1 is elevated in patients with coronary artery disease (CAD) to compensate for the disease-related adverse effects, but less is known about the prognostic role of SIRT 1 regulating microRNAs in patients after coronary artery bypass graft (CABG) surgery.
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    Percutaneous closure of iatrogenic aorta right ventricular fistula
    (2017-10-08T00:00:00Z) ENHOŞ, ASİM; BAKSHALİYEV, NİJAD; AKDEMİR, BARIŞ; HUYUT, MUSTAFA AHMET; KARAÇÖP, ERDEM; GÖKTEKİN, ÖMER; İSMAYILOĞLU, ZİYA; NADİR, AYDIN; YAMAÇ, AYLİN HATİCE; ENHOŞ, ASIM; KARAÇÖP, ERDEM; YAMAÇ, AYLİN HATİCE; NADİR, AYDIN
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    Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry
    (2022-11-01) De Luca G.; Algowhary M.; Uguz B.; Oliveira D. C.; Ganyukov V.; Zimbakov Z.; Cercek M.; Jensen L. O.; Loh P. H.; Calmac L.; et al.; YAMAÇ, AYLİN HATİCE
    The so-called \"smoking paradox\", conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history.
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    Can coronary guidewire save the peripheral day?
    (2018-10-23T00:00:00Z) HUYUT, MUSTAFA AHMET; YAMAÇ, AYLİN HATİCE; Karaçöp, Erdem; ENHOŞ, ASİM; Bakhshaliyev, Nijad; İsmailoğlu, Ziya; Nadir, Aydın; ÖZDEMİR, RAMAZAN; BACAKSIZ, AHMET; KAHRAMAN AY, NURAY; ULUGANYAN, MAHMUT; ÇELİKKALE, İLKE; YAMAÇ, AYLİN HATİCE; ENHOŞ, ASIM; ÖZDEMİR, RAMAZAN; BACAKSIZ, AHMET; KAHRAMAN AY, NURAY