Publication: Effect of bauhinia bauhinioides kallikrein inhibitor on endothelial proliferation and intracellular calcium concentration
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Bilgin, MEHMET
BURGAZLI, K. M.
RAFIQ, A.
MERICLILER, M.
NEUHOF, C.
OLIVA, M. L.
PARAHULEVA, M.
SOYDAN, N.
DOERR, O.
ABDALLAH, Y.
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OBJECTIVES: Proteinase inhibitors act as a defensive system against predators e.g. insects, in plants. Bauhinia bauhinioides kallikrein inhibitor (BbKI) is a serine proteinase inhibitor, isolated from seeds of Bauhinia bauhinioides and is structurally similar to plant Kunitz-type inhibitors but lacks disulfide bridges. In this study we evaluated the antiproliferative effect of BbKI on endothelial cells and its impact on changes in membrane potential and intracellular calcium.
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Bilgin M., BURGAZLI K. M. , RAFIQ A., MERICLILER M., NEUHOF C., OLIVA M. L. , PARAHULEVA M., SOYDAN N., DOERR O., ABDALLAH Y., et al., -Effect of bauhinia bauhinioides kallikrein inhibitor on endothelial proliferation and intracellular calcium concentration-, EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.18, ss.46-51, 2014