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Oxidative Stress Status in Childhood Obesity: A Potential Risk Predictor

dc.contributor.authorKılıç, Elif
dc.contributor.authorOzer, Omer Faruk
dc.contributor.authorErek, Aybala Toprak
dc.contributor.authorERMAN, HAYRİYE
dc.contributor.authorTorun, EMEL
dc.contributor.authorAYHAN, Siddika Kesgin
dc.contributor.authorCaglar, HİFA GÜLRU
dc.contributor.authorSelek, Sahbettin
dc.contributor.authorKocyigit, ABDÜRRAHİM
dc.contributor.institutionauthorÖZER, ÖMER FARUK
dc.contributor.institutionauthorTORUN, EMEL
dc.contributor.institutionauthorÇAĞLAR, HİFA GÜLRU
dc.contributor.institutionauthorSELEK, ŞAHABETTİN
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.date.accessioned2019-10-05T14:12:20Z
dc.date.available2019-10-05T14:12:20Z
dc.date.issued2016-10-13
dc.description.abstractBackground: Childhood obesity characterized by excessive fat in the body is one of the most serious health problems worldwide due to the social, medical, and physiological complications. Obesity and associated diseases are triggering factors for oxidative stress and inflammation. The aim of this study was to explore the possible association between childhood obesity and inflammatory and oxidative status. Material/Methods: Thirty-seven obese children and 37 healthy controls selected from among children admitted to BLIND University Paediatrics Department were included in the study. Anthropometric measurements were performed using standard methods. Glucose, lipid parameters, CRP, insulin, total oxidant status (TOS), total anti-oxidant status (TAS) levels, and total thiol levels (TTL) were measured in serum. HOMA index (HOMA-IR) were calculated. The differences between the groups were evaluated statistically using the Mann-Whitney U test. Results: Body mass index was significantly higher in the obese group (median: 28.31(p<0.001). Glucose metabolism, insulin, and HOMA-IR levels were significantly higher in the obese group (both p<0.001). Total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride levels were significantly higher in the obese group (p<0.001). TAS (med: 2.5 µmol Trolox eq/L (1.7–3.3)) and TOS (med: 49.1 µmol H2 O2 eq/L (34.5–78.8)) levels and TTL (med: 0.22 mmol/L (0.16–0.26)) were significantly higher in the obese group (p=0.001). CRP levels showed positive correlation with TOS and negative correlation with TTL levels (p=0.005, r=0.473; p=0.01, r=–0.417; respectively). TTL levels exhibited negative correlation with TOS levels (p=0.03, r=–0.347). Conclusions: In conclusion, obese children were exposed to more oxidative burden than children with normal weight. Increased systemic oxidative stress induced by childhood obesity can cause development of obesity-related complications and diseases. Widely focussed studies are required on the use of oxidative parameters as early prognostic parameters in detection of obesity-related complicationsen
dc.identifier
dc.identifier.citationKılıç E., Ozer O. F. , Erek A. T. , ERMAN H., Torun E., AYHAN S. K. , Caglar H. G. , Selek S., Kocyigit A., -Oxidative Stress Status in Childhood Obesity: A Potential Risk Predictor-, MEDICAL SCIENCE MONITOR, cilt.22, ss.3673-3679, 2016
dc.identifier.pubmed27733746
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3235
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleOxidative Stress Status in Childhood Obesity: A Potential Risk Predictor
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJOURNAL OF AOAC INTERNATIONAL
local.avesis.id4ec74ded-874b-494a-8dc6-e32bc8c44eea
local.avesis.response3105
local.indexed.atPubMed
local.indexed.atTrDizin
local.org.facultyTıp Fakültesi
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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