Publication: Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy
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2020-09-01T00:00:00Z
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Hasan, Adria
Haque, Ejazul
Hameed, Rohil
Maier, Paul N.
Irfan, Safia
Kamil, Mohd
Nazir, Aamir
Mir, Snober S.
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Abstract
Aims: Hsp90 is regarded as an important therapeutic target in cancer treatment. Client proteins of Hsp90 like Beclin-1, PI3K, and AKT, are associated with tumor development, poor prognosis, and resistance to cancer therapies. This study aims to analyze the role of Gedunin, an Hsp-90 inhibitor, in mediation of crosstalk between apoptosis and autophagy by targeting Beclin-1:Bc1-2 interaction, and ER stress.
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Hasan A., Haque E., Hameed R., Maier P. N. , Irfan S., Kamil M., Nazir A., Mir S. S. , -Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy-, LIFE SCIENCES, cilt.256, 2020