Publication: Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy
Loading...
Program
relationships.isAuthorOf
Author
Hasan, Adria
Haque, Ejazul
Hameed, Rohil
Maier, Paul N.
Irfan, Safia
Kamil, Mohd
Mir, Snober S.
Advisor
Language
Type
Publisher
Journal Title
Journal ISSN
Volume Title
Abstract
Aims: Hsp90 is regarded as an important therapeutic target in cancer treatment. Client proteins of Hsp90 like Beclin-1, PI3K, and AKT, are associated with tumor development, poor prognosis, and resistance to cancer therapies. This study aims to analyze the role of Gedunin, an Hsp-90 inhibitor, in mediation of crosstalk between apoptosis and autophagy by targeting Beclin-1:Bc1-2 interaction, and ER stress.
Description
Source
Keywords
Keywords
Citation
Hasan A., Haque E., Hameed R., Maier P. N. , Irfan S., Kamil M., Nazir A., Mir S. S. , -Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy-, LIFE SCIENCES, cilt.256, 2020