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Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy

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dc.contributor.authorHasan, Adria
dc.contributor.authorHaque, Ejazul
dc.contributor.authorHameed, Rohil
dc.contributor.authorMaier, Paul N.
dc.contributor.authorIrfan, Safia
dc.contributor.authorKamil, Mohd
dc.contributor.authorNazir, Aamir
dc.contributor.authorMir, Snober S.
dc.contributor.institutionauthorKAMIL, MOHD
dc.date.accessioned2020-10-22T18:34:11Z
dc.date.available2020-10-22T18:34:11Z
dc.date.issued2020-09-01T00:00:00Z
dc.description.abstractAims: Hsp90 is regarded as an important therapeutic target in cancer treatment. Client proteins of Hsp90 like Beclin-1, PI3K, and AKT, are associated with tumor development, poor prognosis, and resistance to cancer therapies. This study aims to analyze the role of Gedunin, an Hsp-90 inhibitor, in mediation of crosstalk between apoptosis and autophagy by targeting Beclin-1:Bc1-2 interaction, and ER stress.
dc.identifier.citationHasan A., Haque E., Hameed R., Maier P. N. , Irfan S., Kamil M., Nazir A., Mir S. S. , -Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy-, LIFE SCIENCES, cilt.256, 2020
dc.identifier.doi10.1016/j.lfs.2020.118000
dc.identifier.pubmed32585246
dc.identifier.scopus85086923454
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24176
dc.identifier.wosWOS:000560768500006
dc.titleHsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy
dc.typeArticle
dspace.entity.typePublication
local.avesis.id8ee62947-2085-41b0-8e2d-61f69f2bad43
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery90dbf8d7-063b-4fdc-9373-f3678809a1ea
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relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c

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