Publication: Predictive significance of intraprostatic volumetric parameters derived from early and standard time <SUP>68</SUP>Ga-PSMA PET/CT images in newly diagnosed prostate cancer patients
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Date
2024-07-01
Authors
ERDOĞAN E. B.
TEKÇE E.
KOCA S.
Aslan N.
TOLUK Ö.
AYDIN M.
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Abstract
ObjectiveTo investigate the relationship between intraprostatic Ga-68-prostate-specific membrane antigen (PSMA) uptake values and volumetric parameters derived from early pelvic and standard-time whole-body( 68)Ga-PSMA PET/computed tomography (CT) images in untreated prostate cancer (PCa) patients, and to assess the predictive significance of these data in relation to disease prognosis, comparing them with the Gleason score, clinical risk classification and the presence of metastatic disease detected in Ga-68-PSMA PET/CT imaging. MethodsEighty-one newly diagnosed PCa patients underwent early phase pelvic imaging at the 5th minute and standard time whole-body imaging at the 60th minute. Various threshold values were used in intraprostatic delineations to compute maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), intraprostatic PSMA tumor volume and intraprostatic total lesion PSMA uptake. Correlations between early and standard time measurements, as well as changes in SUV parameters over time, were examined. The association of these values with Gleason score, clinical risk status (National Comprehensive Cancer Network), and metastatic disease was explored. ResultsSUVmax measurements from both early and standard time images distinguished all three groups (clinical risk scores, Gleason score and metastatic group), with standard imaging demonstrating statistical superiority in receiver operating characteristic analyses. Strong correlations were observed between early and standard-time PET parameters. Changes in intraprostatic SUVmax and SUVmean values over time did not exhibit predictive value. ConclusionAlthough intraprostatic PSMA PET parameters generally aligned at both early and standard times, parameters obtained from standard time images showed more robust correlations with clinical risk scores, Gleason score and metastasis status in newly diagnosed, untreated PCa patients. Nucl Med Commun 45: 629-641Copyright (c) 2024 Wolters Kluwer Health, Inc. All rights reserved.
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Tıp, Dahili Tıp Bilimleri, Nükleer Tıp, Sağlık Bilimleri, Medicine, Internal Medicine Sciences, Nuclear medicine, Health Sciences, RADYOLOJİ, NÜKLEER TIP ve MEDİKAL GÖRÜNTÜLEME, Klinik Tıp, Klinik Tıp (MED), RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING, CLINICAL MEDICINE, Clinical Medicine (MED), Radyoloji ve Ultrason Teknolojisi, Radyoloji, Nükleer Tıp ve Görüntüleme, Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and Imaging
Citation
ERDOĞAN E. B., TEKÇE E., KOCA S., Aslan N., TOLUK Ö., AYDIN M., "Predictive significance of intraprostatic volumetric parameters derived from early and standard time <SUP>68</SUP>Ga-PSMA PET/CT images in newly diagnosed prostate cancer patients", NUCLEAR MEDICINE COMMUNICATIONS, cilt.45, sa.7, ss.629-641, 2024