Publication:
Predictive significance of intraprostatic volumetric parameters derived from early and standard time <SUP>68</SUP>Ga-PSMA PET/CT images in newly diagnosed prostate cancer patients

dc.contributor.authorERDOĞAN E. B.
dc.contributor.authorTEKÇE E.
dc.contributor.authorKOCA S.
dc.contributor.authorAslan N.
dc.contributor.authorTOLUK Ö.
dc.contributor.authorAYDIN M.
dc.contributor.institutionauthorERDOĞAN, EZGİ BAŞAK
dc.contributor.institutionauthorTEKÇE, ERTUĞRUL
dc.contributor.institutionauthorTOLUK, ÖZLEM
dc.contributor.institutionauthorAYDIN, MEHMET
dc.contributor.institutionauthorKOCA, SERHAT
dc.date.accessioned2024-07-02T21:50:25Z
dc.date.available2024-07-02T21:50:25Z
dc.date.issued2024-07-01
dc.description.abstractObjective: To investigate the relationship between intraprostatic 68Ga-prostate-specific membrane antigen (PSMA) uptake values and volumetric parameters derived from early pelvic and standard-time whole-body 68Ga-PSMA PET/computed tomography (CT) images in untreated prostate cancer (PCa) patients, and to assess the predictive significance of these data in relation to disease prognosis, comparing them with the Gleason score, clinical risk classification and the presence of metastatic disease detected in 68Ga-PSMA PET/CT imaging. Methods: Eighty-one newly diagnosed PCa patients underwent early phase pelvic imaging at the 5th minute and standard time whole-body imaging at the 60th minute. Various threshold values were used in intraprostatic delineations to compute maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), intraprostatic PSMA tumor volume and intraprostatic total lesion PSMA uptake. Correlations between early and standard time measurements, as well as changes in SUV parameters over time, were examined. The association of these values with Gleason score, clinical risk status (National Comprehensive Cancer Network), and metastatic disease was explored. Results: SUVmax measurements from both early and standard time images distinguished all three groups (clinical risk scores, Gleason score and metastatic group), with standard imaging demonstrating statistical superiority in receiver operating characteristic analyses. Strong correlations were observed between early and standard-time PET parameters. Changes in intraprostatic SUVmax and SUVmean values over time did not exhibit predictive value. Conclusion: Although intraprostatic PSMA PET parameters generally aligned at both early and standard times, parameters obtained from standard time images showed more robust correlations with clinical risk scores, Gleason score and metastasis status in newly diagnosed, untreated PCa patients.
dc.identifier.citationERDOĞAN E. B., TEKÇE E., KOCA S., Aslan N., TOLUK Ö., AYDIN M., "Predictive significance of intraprostatic volumetric parameters derived from early and standard time <SUP>68</SUP>Ga-PSMA PET/CT images in newly diagnosed prostate cancer patients", NUCLEAR MEDICINE COMMUNICATIONS, cilt.45, sa.7, ss.629-641, 2024
dc.identifier.doi10.1097/mnm.0000000000001851
dc.identifier.endpage641
dc.identifier.issn0143-3636
dc.identifier.issue7
dc.identifier.pubmed38835183
dc.identifier.scopus85195253622
dc.identifier.startpage629
dc.identifier.urihttps://hdl.handle.net/20.500.12645/39429
dc.identifier.volume45
dc.identifier.wosWOS:001238962300006
dc.relation.ispartofNUCLEAR MEDICINE COMMUNICATIONS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePredictive significance of intraprostatic volumetric parameters derived from early and standard time <SUP>68</SUP>Ga-PSMA PET/CT images in newly diagnosed prostate cancer patients
dc.typeArticle
dspace.entity.typePublication
local.avesis.id04aecbd1-0563-43c2-90d0-19858d161937
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus
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relation.isAuthorOfPublication.latestForDiscovery98bbbec2-b351-430e-a436-008a1d0a32fd

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