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Identification of Drug-Related Problems and Investigation of Related Factors in Patients with COVID-19: An Observational Study

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dc.contributor.authorBektay M. Y.
dc.contributor.authorSancar M.
dc.contributor.authorOkyaltırık F.
dc.contributor.authorDurdu B.
dc.contributor.authorİzzettin F. V.
dc.contributor.institutionauthorBEKTAY, MUHAMMED YUNUS
dc.contributor.institutionauthorOKYALTIRIK, FATMANUR
dc.contributor.institutionauthorDURDU, BÜLENT
dc.contributor.institutionauthorİZZETTİN, FIKRET VEHBI
dc.date.accessioned2023-01-04T21:38:52Z
dc.date.available2023-01-04T21:38:52Z
dc.date.issued2022-12-01
dc.description.abstractObjective: Clinical prognosis of coronavirus disease-19 (COVID-19) may be severe and unexpected. Patients may quickly progress to respiratory failure, infections, multiple organ dysfunction, and sepsis. The main objective of this study is to investigate the drug-related problems of patients with COVID-19 and related factors. Method: A prospective observational study was conducted on patients with COVID-19 between September 2020 and May 2021. Patients’ demographics, comorbid diseases, prescribed medicines and laboratory findings were recorded. Drug-related problems (DRPs) were identified by a clinical pharmacist according to recent guidelines, UpToDate® clinical decision support system and evidence-based medicine. Results: The median age of 107 patients was 64 and 50.46% of them were male. The median number of comorbidities was 3 (2-4) per patient. The majority of the patients had at least one comorbidity (88.79%) other than COVID-19 and the most frequent comorbidities were hypertension, diabetes mellitus and coronary artery disease. The total number of DRPs was recorded as 201 and at least one DRP was seen in 75 out of 107 patients. The median number of DRPs was 2 (0-8). In multivariate model, number of comorbidities (odss ratio (OR)=1.952; 95% confidence interval (CI)=1.07-3.54, p<0.05, number of medications (OR=1.344; 95% CI=1.12-1.61, p<0.001), and serum potassium levels (OR=5.252; 95% CI=1.57-17.56, p<0.001) were the factors related with DRP. Conclusion: This study highlights the DRPs and related factors in patients with COVID 19 in hospital settings. Considering unknown features of the infection and multiple medication use, DRPs are likely to occur. It would be beneficial to consider the related factors in order to reduce the number of the DRPs.
dc.identifier.citationBektay M. Y., Sancar M., Okyaltırık F., Durdu B., İzzettin F. V., "Identification of Drug-Related Problems and Investigation of Related Factors in Patients with COVID-19: An Observational Study", BEZMIALEM SCIENCE, cilt.10, sa.6, ss.777-785, 2022
dc.identifier.doi10.14235/bas.galenos.2022.63935
dc.identifier.endpage785
dc.identifier.issn2148-2373
dc.identifier.issue6
dc.identifier.startpage777
dc.identifier.urihttps://www.bezmialemscience.org/archives/archive-detail/article-preview/dentification-of-drug-related-problems-and-nvestig/57568
dc.identifier.urihttps://hdl.handle.net/20.500.12645/34568
dc.identifier.volume10
dc.relation.ispartofBEZMIALEM SCIENCE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjecthospital settings
dc.subjectclinical pharmacist
dc.subjectdrugrelated problems
dc.subjectpharmaceutical care need
dc.titleIdentification of Drug-Related Problems and Investigation of Related Factors in Patients with COVID-19: An Observational Study
dc.typearticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery4381d351-4283-4aac-aaa9-56ba24c96613
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