Publication: Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability
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Date
2011-04-01T00:00:00Z
Authors
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Tan, Paul ThiamJoo
KHAN, MOHAMMAD ASİF
August, J. Thomas
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Abstract
Vaccines are the only proven effective method for prevention of human infectious diseases. Almost all traditional vaccines require activating immunological memory B cells to secrete neutralizing antibodies against invading pathogens. The complication with influenza viruses is the high viral mutation rate that results in immune escape through modification of the B cell epitopes. Studies of T cell immunity to influenza infection provide an alternative vaccine strategy based on highly conserved T cell epitopes. In this review, we discuss the importance of T cell-mediated immunity in influenza infection and the need for a targeted vaccine approach focused on highly conserved T cell epitopes to mitigate immune escape. We propose 15 highly conserved pan-influenza sequences as potential T cell epitopes-based vaccine targets for broad protection and lasting immunity against variant influenza strains.
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Tan P. T. , KHAN M. A. , August J. T. , -Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability-, HUMAN VACCINES, cilt.7, sa.4, ss.402-409, 2011