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Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability

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dc.contributor.authorTan, Paul ThiamJoo
dc.contributor.authorKHAN, MOHAMMAD ASİF
dc.contributor.authorAugust, J. Thomas
dc.contributor.institutionauthorKHAN, MOHAMMAD ASİF
dc.date.accessioned2021-09-01T20:59:13Z
dc.date.available2021-09-01T20:59:13Z
dc.date.issued2011-04-01T00:00:00Z
dc.description.abstractVaccines are the only proven effective method for prevention of human infectious diseases. Almost all traditional vaccines require activating immunological memory B cells to secrete neutralizing antibodies against invading pathogens. The complication with influenza viruses is the high viral mutation rate that results in immune escape through modification of the B cell epitopes. Studies of T cell immunity to influenza infection provide an alternative vaccine strategy based on highly conserved T cell epitopes. In this review, we discuss the importance of T cell-mediated immunity in influenza infection and the need for a targeted vaccine approach focused on highly conserved T cell epitopes to mitigate immune escape. We propose 15 highly conserved pan-influenza sequences as potential T cell epitopes-based vaccine targets for broad protection and lasting immunity against variant influenza strains.
dc.identifier.citationTan P. T. , KHAN M. A. , August J. T. , -Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability-, HUMAN VACCINES, cilt.7, sa.4, ss.402-409, 2011
dc.identifier.doi10.4161/hv.7.4.13845
dc.identifier.scopus79955042531
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29332
dc.identifier.wosWOS:000289937500011
dc.titleHighly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability
dc.typeArticle
dspace.entity.typePublication
local.avesis.id1a7aa846-149f-4433-b9fd-f6e742351148
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery60fee672-8864-4711-ae92-5b9dd3bb0ef7
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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