Publication: Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability
dc.contributor.author | Tan, Paul ThiamJoo | |
dc.contributor.author | KHAN, MOHAMMAD ASİF | |
dc.contributor.author | August, J. Thomas | |
dc.contributor.institutionauthor | KHAN, MOHAMMAD ASİF | |
dc.date.accessioned | 2021-09-01T20:59:13Z | |
dc.date.available | 2021-09-01T20:59:13Z | |
dc.date.issued | 2011-04-01T00:00:00Z | |
dc.description.abstract | Vaccines are the only proven effective method for prevention of human infectious diseases. Almost all traditional vaccines require activating immunological memory B cells to secrete neutralizing antibodies against invading pathogens. The complication with influenza viruses is the high viral mutation rate that results in immune escape through modification of the B cell epitopes. Studies of T cell immunity to influenza infection provide an alternative vaccine strategy based on highly conserved T cell epitopes. In this review, we discuss the importance of T cell-mediated immunity in influenza infection and the need for a targeted vaccine approach focused on highly conserved T cell epitopes to mitigate immune escape. We propose 15 highly conserved pan-influenza sequences as potential T cell epitopes-based vaccine targets for broad protection and lasting immunity against variant influenza strains. | |
dc.identifier.citation | Tan P. T. , KHAN M. A. , August J. T. , -Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability-, HUMAN VACCINES, cilt.7, sa.4, ss.402-409, 2011 | |
dc.identifier.doi | 10.4161/hv.7.4.13845 | |
dc.identifier.scopus | 79955042531 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12645/29332 | |
dc.identifier.wos | WOS:000289937500011 | |
dc.title | Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.avesis.id | 1a7aa846-149f-4433-b9fd-f6e742351148 | |
local.publication.goal | 03 - Sağlık ve Kaliteli Yaşam | |
local.publication.isinternational | 1 | |
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