Stroke and dilated cardiomyopathy associated with celiac disease

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Dogan, Murat
Peker, Erdal
Cagan, Eren
Akbayram, Sinan
Acikgoz, Mehmet
Caksen, Huseyin
Uner, Abdurrahman
Cesur, YAŞAR
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Celiac disease (CD) is manifested by a variety of clinical signs and symptoms that may begin either in childhood or adult life. Neurological symptoms without signs of malabsorption have been observed for a long time in CD. In this report, an 8-year-old girl with CD presented with rarely seen dilated cardiomyopathy and stroke. The girl was admitted with left side weakness. Her medical history indicated abdominal distention, chronic diarrhea, failure to thrive, and geophagia. On physical examination, short stature, pale skin and a grade 2 of 6 systolic murmur were detected. Muscle strength was 0/5 on the left side, and 5/5 on the right side. Coagulation examinations were normal. Tests for collagen tissue diseases were negative. Factor V Leiden and prothrombin GA20210 mutations were negative. Tandem mass spectrophotometry and blood carnitine profiles were normal. Brain magnetic resonance imaging and cerebral angiography showed an infarction area at the basal ganglia level. Examinations of serologic markers and intestinal biopsy revealed CD. We emphasize that in differential diagnosis of ischemic stroke, CD should be kept in mind. (C) 2010 Baishideng. All rights reserved.
Dogan M., Peker E., Cagan E., Akbayram S., Acikgoz M., Caksen H., Uner A., Cesur Y., -Stroke and dilated cardiomyopathy associated with celiac disease-, WORLD JOURNAL OF GASTROENTEROLOGY, cilt.16, ss.2302-2304, 2010
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