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Acromegaly can be associated with impairment of LES relaxation in the oesophagus

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dc.contributor.authorIlhan, MAHMUT MUZAFFER
dc.contributor.authorDANALIOGLU, Ahmet
dc.contributor.authorTurgut, SEDA
dc.contributor.authorKaraman, Ozcan
dc.contributor.authorArabaci, ELİF
dc.contributor.authorTasan, ERTUĞRUL
dc.contributor.institutionauthorİLHAN, MAHMUT MUZAFFER
dc.contributor.institutionauthorTURGUT, SEDA
dc.contributor.institutionauthorKARAMAN, ÖZCAN
dc.contributor.institutionauthorARABACI, ELİF
dc.contributor.institutionauthorTAŞAN, ERTUĞRUL
dc.date.accessioned2019-10-05T21:55:59Z
dc.date.available2019-10-05T21:55:59Z
dc.date.issued2015-09-01
dc.description.abstractIntroduction: Although prolonged small intestine and colonic transit time has been demonstrated in acromegaly patients, the influence of acromegaly on oesophagus motility and the pathological mechanisms involved are still not clarified. We aimed to investigate manometric measurements to ascertain whether oesophagus motility is affected in active acromegaly patients. Material and methods: The study was performed in an institutional referral centre at a tertiary care hospital. Twenty-three acromegaly patients (mean age 43.2 ± 13.2 years) and 25 sex- and age-matched healthy control subjects (mean age 48.6 ± 7.9 years) were recruited to a case-control study. Oesophageal manometry was performed using MMS (Medical Measurement Systems, Netherlands) Solar GI — Air Charged Intelligent Gastrointestinal Conventional Manometry. Results: In manometric measurements the lower oesophageal sphincter pressure was 18 ± 7 mmHg in acromegaly patients and 15.6 ± 4.4 mm Hg in controls, and there was no significant difference (p = 0.17). The percentage of relaxation was 64.8% and 81.8%, respectively, and it was significantly lower in acromegaly patients than in controls (p < 0.001). Additionally, the duration of relaxation was found to be 4 ± 1.9 seconds and 5 ± 1.7 seconds in patients and controls, respectively (p = 0.049). Conclusions: Our study has demonstrated a significant reduction in the percentage and duration of lower oesophageal sphincter relaxation in oesophagus motility even in acromegaly patients without any gastrointestinal symptoms. Further clinical and pathophysiological studies are required to clarify the underlying mechanisms of gastrointestinal motility disorders in acromegalyen
dc.identifier10.1186/1752-1947-8-146
dc.identifier.citationIlhan M. M. , DANALIOGLU A., Turgut S., Karaman O., Arabaci E., Tasan E., -Acromegaly can be associated with impairment of LES relaxation in the oesophagus-, ENDOKRYNOLOGIA POLSKA, cilt.66, ss.308-312, 2015
dc.identifier.doi10.5603/ep.2015.0039
dc.identifier.pubmed26323467
dc.identifier.scopus84942090829
dc.identifier.urihttps://hdl.handle.net/20.500.12645/8483
dc.identifier.wosWOS:000360705000006
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleAcromegaly can be associated with impairment of LES relaxation in the oesophagus
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJournal of medical case reports
local.avesis.idd390635c-a1bf-4578-b389-0852129e43de
local.avesis.response8359
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscoverybb0cdccb-8967-47e2-aff8-3e4d4996a57e
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