Publication: Acromegaly can be associated with impairment of LES relaxation in the oesophagus
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Authors
Ilhan, MAHMUT MUZAFFER
DANALIOGLU, Ahmet
Turgut, SEDA
Karaman, Ozcan
Arabaci, ELİF
Tasan, ERTUĞRUL
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Abstract
Introduction: Although prolonged small intestine and colonic transit time has been demonstrated in acromegaly patients, the influence of
acromegaly on oesophagus motility and the pathological mechanisms involved are still not clarified. We aimed to investigate manometric
measurements to ascertain whether oesophagus motility is affected in active acromegaly patients.
Material and methods: The study was performed in an institutional referral centre at a tertiary care hospital. Twenty-three acromegaly
patients (mean age 43.2 ± 13.2 years) and 25 sex- and age-matched healthy control subjects (mean age 48.6 ± 7.9 years) were recruited to
a case-control study. Oesophageal manometry was performed using MMS (Medical Measurement Systems, Netherlands) Solar GI — Air
Charged Intelligent Gastrointestinal Conventional Manometry.
Results: In manometric measurements the lower oesophageal sphincter pressure was 18 ± 7 mmHg in acromegaly patients and
15.6 ± 4.4 mm Hg in controls, and there was no significant difference (p = 0.17). The percentage of relaxation was 64.8% and 81.8%,
respectively, and it was significantly lower in acromegaly patients than in controls (p < 0.001). Additionally, the duration of relaxation
was found to be 4 ± 1.9 seconds and 5 ± 1.7 seconds in patients and controls, respectively (p = 0.049).
Conclusions: Our study has demonstrated a significant reduction in the percentage and duration of lower oesophageal sphincter relaxation
in oesophagus motility even in acromegaly patients without any gastrointestinal symptoms. Further clinical and pathophysiological studies
are required to clarify the underlying mechanisms of gastrointestinal motility disorders in acromegaly
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Ilhan M. M. , DANALIOGLU A., Turgut S., Karaman O., Arabaci E., Tasan E., -Acromegaly can be associated with impairment of LES relaxation in the oesophagus-, ENDOKRYNOLOGIA POLSKA, cilt.66, ss.308-312, 2015