Publication: Ribavirin is not effective against Crimean-Congo hemorrhagic fever: observations from the Turkish experience
Program
Authors
Authors
CEYLAN, Bahadir
CALICA, Aylin
AK, Oznur
Akkoyunlu, YASEMİN
TURHAN, Vedat
Advisor
Date
Language
Type
Publisher
Journal Title
Journal ISSN
Volume Title
Abstract
Crimean–Congo hemorrhagic fever (CCHF) is a viral infection associated with a high mortality rate.
Ribavirin is the only drug used in the treatment of this disease. Studies investigating the effectiveness of
ribavirin in CCHF have been retrospective and to date have included only a small number of cases. In
recent years, due to climate changes, the number of cases of CCHF in Turkey has increased, and
experience in the treatment of CCHF has improved. Several studies have evaluated the efficacy of
ribavirin in Turkey, including one randomized controlled trial and two studies with a large number
of cases. In these studies, ribavirin therapy was not shown to decrease mortality rates; the mortality rate
was 2–9% in patients treated with ribavirin and 5.6–11% in those who were not treated with this drug.
These findings suggest that patients with CCHF should be followed with supportive care only until
randomized controlled trials with larger groups have been conducted.
Description
Source:
Keywords:
Keywords
Citation
CEYLAN B., CALICA A., AK O., Akkoyunlu Y., TURHAN V., -Ribavirin is not effective against Crimean-Congo hemorrhagic fever: observations from the Turkish experience-, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, cilt.17, 2013