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Ribavirin is not effective against Crimean-Congo hemorrhagic fever: observations from the Turkish experience

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dc.contributor.authorCEYLAN, Bahadir
dc.contributor.authorCALICA, Aylin
dc.contributor.authorAK, Oznur
dc.contributor.authorAkkoyunlu, YASEMİN
dc.contributor.authorTURHAN, Vedat
dc.contributor.institutionauthorAKKOYUNLU, YASEMİN
dc.date.accessioned2019-10-05T21:26:09Z
dc.date.available2019-10-05T21:26:09Z
dc.date.issued2013-10-01
dc.description.abstractCrimean–Congo hemorrhagic fever (CCHF) is a viral infection associated with a high mortality rate. Ribavirin is the only drug used in the treatment of this disease. Studies investigating the effectiveness of ribavirin in CCHF have been retrospective and to date have included only a small number of cases. In recent years, due to climate changes, the number of cases of CCHF in Turkey has increased, and experience in the treatment of CCHF has improved. Several studies have evaluated the efficacy of ribavirin in Turkey, including one randomized controlled trial and two studies with a large number of cases. In these studies, ribavirin therapy was not shown to decrease mortality rates; the mortality rate was 2–9% in patients treated with ribavirin and 5.6–11% in those who were not treated with this drug. These findings suggest that patients with CCHF should be followed with supportive care only until randomized controlled trials with larger groups have been conducted.en
dc.identifier10.1159/000070010
dc.identifier.citationCEYLAN B., CALICA A., AK O., Akkoyunlu Y., TURHAN V., -Ribavirin is not effective against Crimean-Congo hemorrhagic fever: observations from the Turkish experience-, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, cilt.17, 2013
dc.identifier.doi10.1016/j.ijid.2013.02.030
dc.identifier.pubmed23773242
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7292
dc.identifier.wosWOS:000324476200002
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectCrimean-Congo hemorrhagic fever
dc.titleRibavirin is not effective against Crimean-Congo hemorrhagic fever: observations from the Turkish experience
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameNeuropsychobiology
local.avesis.idb5a1b5e5-a38f-4e2e-9dc9-143d67f0d488
local.avesis.response7168
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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