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Effectiveness of Diffusion Tensor Imaging in the Microstructural Evaluation of Corpus Callosum and Brain Parenchyma in Children with Neurofibromatosis Type I

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dc.contributor.authorÇEŞME, DİLEK HACER
dc.contributor.institutionauthorÇEŞME, DİLEK HACER
dc.date.accessioned2021-05-18T20:59:10Z
dc.date.available2021-05-18T20:59:10Z
dc.date.issued2021-04-01T00:00:00Z
dc.description.abstractObjective: To compare tractional anisotropy (FA) and mean diffusivity (MD) values obtained from corpus callosum (CC), basal ganglion, thalamus, frontal and parietal white matter in NF1 patients compared to the control group and to investigate the correlation with CC volume. Methods: Thirty three cases diagnosed with NF1 and 21 healthy control groups were included in the study. CC volume was measured in both groups. Using tensor imaging (DTI), MD and FA values were calculated from CC genu and splenium, globus pallidum, caudate nucleus, putamen, thalamus, parietal and frontal white matter. Results: CC volume increased significantly in cases with NF1. There was a significant difference in MD and FA values obtained from CC genu and splenium compared to the control group. MD values obtained from frontal and parietal white matter, globus pallidum, putamen, thalamus and caudate nucleus were significantly higher than the control group. FA values decreased in caudate nucleus and putamen while FA values in globus pallidum were higher than control group. There was a negative correlation between CC volume and MD values obtained from KK splenium, putamen, thalamus and caudate nucleus Conclusion: Increased MD in areas of involvement in NF1 cases can be explained by impaired myelination and demyelination. Heterogeneity in FA values suggests that it is caused by microstructural differences resulting from the breakdown of myelin sheaths or axonal disruption in different locations of the brain. In cases with NF1, DTI findings will help us to understand the occurrence of the disease and the physiopathology of clinical findings in more detail.
dc.identifier.citationÇeşme DH. Effectiveness of Diffusion Tensor Imaging in the Microstructural Evaluation of Corpus Callosum and Brain Parenchyma in Children with Neurofibromatosis Type I. Bezmialem Science 2021;9(2):171-6.
dc.identifier.doi10.14235/bas.galenos.2020.4571
dc.identifier.trdizin422297
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28894
dc.identifier.wosWOS:000640072700010
dc.subjectNeurofibromatosis type I
dc.subjectcorpus callosum
dc.subjectdiffusion tensor imaging
dc.subjectMD
dc.subjectFA
dc.titleEffectiveness of Diffusion Tensor Imaging in the Microstructural Evaluation of Corpus Callosum and Brain Parenchyma in Children with Neurofibromatosis Type I
dc.typeArticle
dspace.entity.typePublication
local.avesis.id4f1ecb65-18a4-404b-a034-5dda4d98c241
local.publication.isinternational1
relation.isAuthorOfPublication8f22e561-a9e8-421b-91c9-84dd966cca63
relation.isAuthorOfPublication.latestForDiscovery8f22e561-a9e8-421b-91c9-84dd966cca63
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