Publication: Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats
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2017-09-01T00:00:00Z
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Bami, Erliasa
Ozakpinar, Ozlem Bingol
Ozdemir-Kumral, Zarife Nigar
Koroglu, Kutay
ERCAN, FERİHA
CIRAKLI, Zeynep
ŞEKERLER, TURGUT
Izzettin, FİKRET VEHBİ
SANCAR, MESUT
OKUYAN, BETÜL
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Abstract
This study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p < 0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals (p < 0.05). All parameters showed improvement in groups treated with ferulic acid (p < 0.05). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound.
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Bami E., Ozakpinar O. B. , Ozdemir-Kumral Z. N. , Koroglu K., ERCAN F., CIRAKLI Z., ŞEKERLER T., Izzettin F. V. , SANCAR M., OKUYAN B., -Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats-, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, cilt.54, ss.105-111, 2017