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Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats

dc.contributor.authorBami, Erliasa
dc.contributor.authorOzakpinar, Ozlem Bingol
dc.contributor.authorOzdemir-Kumral, Zarife Nigar
dc.contributor.authorKoroglu, Kutay
dc.contributor.authorERCAN, FERİHA
dc.contributor.authorCIRAKLI, Zeynep
dc.contributor.authorŞEKERLER, TURGUT
dc.contributor.authorIzzettin, FİKRET VEHBİ
dc.contributor.authorSANCAR, MESUT
dc.contributor.authorOKUYAN, BETÜL
dc.contributor.institutionauthorİZZETTİN, FIKRET VEHBI
dc.date.accessioned2020-10-29T17:19:27Z
dc.date.available2020-10-29T17:19:27Z
dc.date.issued2017-09-01T00:00:00Z
dc.description.abstractThis study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p < 0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals (p < 0.05). All parameters showed improvement in groups treated with ferulic acid (p < 0.05). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound.
dc.identifier.citationBami E., Ozakpinar O. B. , Ozdemir-Kumral Z. N. , Koroglu K., ERCAN F., CIRAKLI Z., ŞEKERLER T., Izzettin F. V. , SANCAR M., OKUYAN B., -Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats-, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, cilt.54, ss.105-111, 2017
dc.identifier.doi10.1016/j.etap.2017.06.026
dc.identifier.scopus85021892462
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25673
dc.identifier.wosWOS:000409288300015
dc.titleProtective effect of ferulic acid on cisplatin induced nephrotoxicity in rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.id3c8e9fd4-ee77-4685-8815-3ba25ca34545
local.publication.isinternational1
relation.isAuthorOfPublicationcc4fb95b-daac-4065-9eea-9b57f6b44654
relation.isAuthorOfPublication.latestForDiscoverycc4fb95b-daac-4065-9eea-9b57f6b44654
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