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Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women

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dc.contributor.authorZORLU, MEHMET
dc.contributor.authorŞEKERCİ, ABDÜSSELAM
dc.contributor.authorTUNÇ, MUHAMMED
dc.contributor.authorGüler, Eray Metin
dc.contributor.authorGülen, Bedia
dc.contributor.authorKARATOPRAK, CUMALİ
dc.contributor.authorKISKAÇ, MUHARREM
dc.contributor.authorÇAKIRCA, MUSTAFA
dc.contributor.institutionauthorZORLU, MEHMET
dc.contributor.institutionauthorŞEKERCİ, ABDÜSSELAM
dc.contributor.institutionauthorTUNÇ, MUHAMMED
dc.contributor.institutionauthorKARATOPRAK, CUMALİ
dc.contributor.institutionauthorKISKAÇ, MUHARREM
dc.contributor.institutionauthorÇAKIRCA, MUSTAFA
dc.date.accessioned2022-09-27T20:59:07Z
dc.date.available2022-09-27T20:59:07Z
dc.date.issued2022-01-01T00:00:00Z
dc.description.abstractBackground: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the vitamin D groups (p < 0.05). A significant positive correlation was detected between vitamin D, and adropin and TAS (r = 0.807; p < 0.001, r = 0.814; p < 0.001, respectively). A significant negative correlation was detected between vitamin D, and IL-1ß, IL-6, TOS, OSI (r = -0.725; p < 0.001, r = -0.720; p < 0.001, r = -0.238; p = 0.037, r = -0.705; p < 0.001, respectively). Discussion: Vitamin D could show its effects through vitamin D receptors on tissues or on the ENHO gene in adropin secreting tissues via direct or indirect mechanisms. Proinflammatory cytokines, oxidative stress, and adropin targeted studies could contribute to the prevention and treatment of diseases associated with vitamin D deficiency in future.
dc.identifier.citationZORLU M., ŞEKERCİ A., TUNÇ M., Güler E. M. , Gülen B., KARATOPRAK C., KISKAÇ M., ÇAKIRCA M., -Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women-, Turkish Journal of Medical Sciences, cilt.52, sa.4, ss.1197-1206, 2022
dc.identifier.doi10.55730/1300-0144.5424
dc.identifier.pubmed36326375
dc.identifier.scopus85136827766
dc.identifier.trdizin1144815
dc.identifier.urihttp://hdl.handle.net/20.500.12645/31027
dc.identifier.wosWOS:000881194200039
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIL-1 beta
dc.subjectIL-6
dc.subjectVitamin D
dc.subjectadropin
dc.subjectoxidative stress
dc.titleEvaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women
dc.typeArticle
dspace.entity.typePublication
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local.publication.isinternational1
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