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Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy

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Date
2014-01-01
Authors
ZHAO, Jiacheng
BABIUCH, Krzysztof
Lu, Hongxu
Dag, AYDAN
GOTTSCHALDT, Michael
STENZEL, Martina H.
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Abstract
Fructose transporter GLUT5 is overexpressed in breast cancer cell lines, but not in healthy tissue. Micelles based on fructose, which were found to be low fouling, showed a high uptake by breast cancer cells (MCF-7 and MDA-MB-231 cells), but only negligible uptake by macrophages.
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ZHAO J., BABIUCH K., Lu H., Dag A., GOTTSCHALDT M., STENZEL M. H. , -Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy-, CHEMICAL COMMUNICATIONS, cilt.50, ss.15928-15931, 2014
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