Publication: Development of phytoactive essential oils-composed organogels against oral pathogens
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Date
2024-08-01
Authors
ALĞIN YAPAR E.
Gökçe E. H.
Şahiner A.
İNAL E.
ULUSOY Ş.
Souto E. B.
Akanoğlu B.
KARTAL M.
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Abstract
Gingivitis, one of the most common periodontal diseases, is the inflammation of the gingival tissues that causes swelling, tenderness, redness and bleeding. The treatment should contain anti-inflammatory, antibacterial, and antioxidant agents to decrease the risk of dental plaque formation and periodontal tissue damage in the inflammatory process. In line with the antibacterial, antifungal, and antioxidant effects of the geranium (Pelargonium graveolens L\"Hér.) herb, common sage (Salvia officinalis L.) herb, and mastic tree (Pistacia lentiscus L.) leaf, in this work we propose their use as active pharmaceutical ingredients of periodontal gels. The organogel formulations were produced either by microwave-assisted irradiation method or by the conventional approach (microwave-free), and further characterized for their physicochemical properties, antimicrobial efficacy and cell viability. Among them, the gel formulation containing 4 % geranium essential oil obtained by the conventional method was identified as the best candidate to be developed as an effective and safe alternative suitable for oromucosal applications.
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Keywords
Tıp, Sağlık Bilimleri, Medicine, Health Sciences, Klinik Tıp (MED), Klinik Tıp, TROPİKAL TIP, Clinical Medicine (MED), CLINICAL MEDICINE, TROPICAL MEDICINE, Farmasötik bilim, Yaşam Bilimleri, Pharmaceutical Science, Life Sciences, Common sage, Geranium Pelargonium graveolens L'Hér, Mastic tree, Pistacia lentiscus L.
Citation
ALĞIN YAPAR E., Gökçe E. H., Şahiner A., İNAL E., ULUSOY Ş., Souto E. B., Akanoğlu B., KARTAL M., "Development of phytoactive essential oils-composed organogels against oral pathogens", Journal of Drug Delivery Science and Technology, cilt.97, 2024