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Acute kidney injury in Turkey: epidemiological characteristics, etiology, clinical course, and prognosis

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dc.contributor.authorGÜRSU, Meltem
dc.contributor.authorYegenaga, Itir
dc.contributor.authorTUĞLULAR, ZÜBEYDE SERHAN
dc.contributor.authorDURSUN, BELDA
dc.contributor.authorGÖKÇAY BEK, SİBEL
dc.contributor.authorBardak, Simge
dc.contributor.authorONAN, ENGİN
dc.contributor.authorDemir, Serap
dc.contributor.authorDERİCİ, ÜLVER
dc.contributor.authorDOĞUKAN, AYHAN
dc.contributor.authorSevinc, Mustafa
dc.contributor.authorKOÇYİĞİT, İSMAİL
dc.contributor.authorAltun, Eda
dc.contributor.authorHaras, Ali Burak
dc.contributor.authorALTIPARMAK, Mehmet Rıza
dc.contributor.authorTONBUL, HALİL ZEKİ
dc.contributor.institutionauthorGÜRSU, MELTEM
dc.date.accessioned2022-10-18T20:59:07Z
dc.date.available2022-10-18T20:59:07Z
dc.date.issued2022-10-01T00:00:00Z
dc.description.abstractBackground: This study aimed to evaluate the etiologies, comorbidities, and outcomes of acute kidney injury (AKI) in Turkey and determine any potential differences among different geographical parts of the country. Methods: This prospective observational study was conducted by the Acute Kidney Injury Working Group of the Turkish Society of Nephrology. Demographical and clinical data of patients with AKI at the time of diagnosis and at the 1st week and 1st, 3rd, and 6th months of diagnosis were evaluated to determine patient and renal survival and factors associated with patient prognosis. Results: A total of 776 patients were included (54.7% male, median age: 67 years). Prerenal etiologies, including dehydration, heart failure, and sepsis, were more frequent than other etiologies. 58.9% of the patients had at least one renal etiology, with nephrotoxic agent exposure as the most common etiology. The etiologic factors were mostly similar throughout the country. 33.6% of the patients needed kidney replacement therapy. At the 6th month of diagnosis, 29.5% of the patients had complete recovery; 34.1% had partial recovery; 9.5% developed end-stage kidney disease; and 24.1% died. The mortality rate was higher in the patients from the Eastern Anatolian region; those admitted to the intensive care unit; those with prerenal, renal, and postrenal etiologies together, stage 3 AKI, sepsis, cirrhosis, heart failure, and malignancy; those who need kidney replacement therapy; and those without chronic kidney disease than in the other patients. Conclusion: Physicians managing patients with AKI should be alert against dehydration, heart failure, sepsis, and nephrotoxic agent exposure. Understanding the characteristics and outcomes of patients with AKI in their countries would help prevent AKI and improve treatment strategies.
dc.identifier.citationGÜRSU M., Yegenaga I., TUĞLULAR Z. S. , DURSUN B., GÖKÇAY BEK S., Bardak S., ONAN E., Demir S., DERİCİ Ü., DOĞUKAN A., et al., -Acute kidney injury in Turkey: epidemiological characteristics, etiology, clinical course, and prognosis-, BMC NEPHROLOGY, cilt.23, sa.1, 2022
dc.identifier.doi10.1186/s12882-022-02933-1
dc.identifier.pubmed36199011
dc.identifier.scopus85139277267
dc.identifier.urihttp://hdl.handle.net/20.500.12645/31138
dc.identifier.wosWOS:000864294300001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute kidney injury
dc.subjectEtiology
dc.subjectKidney replacement therapy
dc.subjectSurvival
dc.titleAcute kidney injury in Turkey: epidemiological characteristics, etiology, clinical course, and prognosis
dc.typeArticle
dspace.entity.typePublication
local.avesis.id5359271c-a9a6-4818-90c1-2344a1e8e5f1
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscoverya6446eac-0ccd-4457-9227-3fc72dec68d1
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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