Publication:
Investigation of the Vitamin D Receptor Polymorphisms in Acromegaly Patients

Loading...
Thumbnail Image

Date

2015-01-01

Authors

Ilhan, MAHMUT MUZAFFER
TOPTAS-HEKIMOGLU, Bahar
YAYLIM, Ilhan
Turgut, SEDA
TURAN, Saime
Karaman, Ozcan
Tasan, ERTUĞRUL

Journal Title

Journal ISSN

Volume Title

Publisher

Research Projects

Organizational Units

Journal Issue

Metrics

Search on Google Scholar

Abstract

Objective. The genetic structural alterations in the majority of somatotroph adenomas are not clarified and the search for novel candidate genes is still a challenge.We aimed to investigate possible associations between vitamin D receptor (VDR) polymorphisms and acromegaly. Design, Patients, and Methods. 52 acromegaly patients (mean age 45.7 ± 1.9 years) and 83 controls (mean age 43.1 ± 2.6 years) were recruited to the study. VDR polymorphism was determined by polymerase chain reaction-based restriction fragment length polymorphism methods. Results. The distribution of VDR genotypes showed a significant difference in the frequencies of VDR FokI genotypes between patients and controls (𝑃 = 0.034). VDR FokI ff genotype was significantly decreased in acromegaly patients (𝑃 = 0.035) and carriers of FokI Ff genotype had a 1.5-fold increased risk for acromegaly (OR: 1.5, 95% CI: 1.07–2.1; 𝑃 = 0.020). IGF1 levels after treatment were significantly higher in patients carrying the Ff genotype compared to carrying ff genotype (𝑃 = 0.0049). 25(OH)D3 levels were significantly lower in acromegaly patients (𝑃 < 0.001). Conclusions. Our study suggests that VDR FokI genotypes might affect the development of acromegaly and VDR polymorphisms may play a role in the course of acromegaly as a consequence of altering hormonal status.

Description

Keywords

Vitamin D

Citation

Ilhan M. M. , TOPTAS-HEKIMOGLU B., YAYLIM I., Turgut S., TURAN S., Karaman O., Tasan E., -Investigation of the Vitamin D Receptor Polymorphisms in Acromegaly Patients-, BIOMED RESEARCH INTERNATIONAL, 2015
Page Views

0

File Downloads

5

Sustainable Development Goals