Publication: Investigation of the Vitamin D Receptor Polymorphisms in Acromegaly Patients
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Date
2015-01-01
Authors
Ilhan, MAHMUT MUZAFFER
TOPTAS-HEKIMOGLU, Bahar
YAYLIM, Ilhan
Turgut, SEDA
TURAN, Saime
Karaman, Ozcan
Tasan, ERTUĞRUL
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Abstract
Objective. The genetic structural alterations in the majority of somatotroph adenomas are not clarified and the search for novel
candidate genes is still a challenge.We aimed to investigate possible associations between vitamin D receptor (VDR) polymorphisms
and acromegaly. Design, Patients, and Methods. 52 acromegaly patients (mean age 45.7 ± 1.9 years) and 83 controls (mean age 43.1 ±
2.6 years) were recruited to the study. VDR polymorphism was determined by polymerase chain reaction-based restriction fragment
length polymorphism methods. Results. The distribution of VDR genotypes showed a significant difference in the frequencies of
VDR FokI genotypes between patients and controls (𝑃 = 0.034). VDR FokI ff genotype was significantly decreased in acromegaly
patients (𝑃 = 0.035) and carriers of FokI Ff genotype had a 1.5-fold increased risk for acromegaly (OR: 1.5, 95% CI: 1.07–2.1;
𝑃 = 0.020). IGF1 levels after treatment were significantly higher in patients carrying the Ff genotype compared to carrying ff
genotype (𝑃 = 0.0049). 25(OH)D3 levels were significantly lower in acromegaly patients (𝑃 < 0.001). Conclusions. Our study
suggests that VDR FokI genotypes might affect the development of acromegaly and VDR polymorphisms may play a role in the
course of acromegaly as a consequence of altering hormonal status.
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Keywords
Vitamin D
Citation
Ilhan M. M. , TOPTAS-HEKIMOGLU B., YAYLIM I., Turgut S., TURAN S., Karaman O., Tasan E., -Investigation of the Vitamin D Receptor Polymorphisms in Acromegaly Patients-, BIOMED RESEARCH INTERNATIONAL, 2015