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Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption

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dc.contributor.authorSen, Alaattin
dc.contributor.authorAyar, Buket
dc.contributor.authorYilmaz, Anil
dc.contributor.authorAcar, Ozden Ozgun
dc.contributor.authorTurgut, Gurbet Celik
dc.contributor.authorTOPÇU, GÜLAÇTI
dc.contributor.institutionauthorYILMAZ, ANIL
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.date.accessioned2020-01-15T20:36:16Z
dc.date.available2020-01-15T20:36:16Z
dc.date.issued2019-01-01T00:00:00Z
dc.description.abstractTeucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, isolated from Teucrium alyssifolium. The lactate dehydrogenase (LDH) cytotoxicity assay, glucose uptake test, glucose utilization (glycogen content) test, glucose transport test, glucose absorption (a-glucosidase activity) test, insulin secretion test, RNA isolation and cDNA synthesis assay, qPCR quantification assays, and statistical analyses were carried out in the present study. Alysine A exerted the following effects at non-cytotoxic doses:
dc.identifier.citationSen A., Ayar B., Yilmaz A., Acar O. O. , Turgut G. C. , TOPÇU G., -Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption-, TURKISH JOURNAL OF CHEMISTRY, cilt.43, ss.1350-1372, 2019
dc.identifier.doi10.3906/kim-1904-57
dc.identifier.scopus85073800115
dc.identifier.trdizinDOI: https://doi.org/10.3906/kim-1904-57
dc.identifier.trdizinDOI: https://doi.org/10.3906/kim-1904-57
dc.identifier.trdizintrdizin
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/13219
dc.identifier.wosWOS:000489111500010
dc.language.isoen
dc.titleNatural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption
dc.typeArticle
dspace.entity.typePublication
local.avesis.id95ceea2d-53d2-41af-a92e-f2bdbb9e239d
local.publication.isinternational1
relation.isAuthorOfPublication9c5ef152-9387-4153-86b3-556fc729d785
relation.isAuthorOfPublication3c94748e-c303-4294-ad67-c5a0739628e5
relation.isAuthorOfPublication.latestForDiscovery3c94748e-c303-4294-ad67-c5a0739628e5
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