Publication: Prospective associations of cardiovascular disease with physical performance and disability : A longitudinal cohort study in the Osteoarthritis Initiative.
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Authors
Authors
Soysal, PINAR
Veronese, N
Stubbs, B
Koyanagi, A
Noventa, V
Bolzetta, F
López-Sánchez, GF
Maggi, S
Jackson, SE
Loosemore, M
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Abstract
Background Literature regarding cardiovascular disease (CVD) and incident physical performance limitations and disability in older people is equivocal.
Aims This study aimed to investigate whether CVD is
longitudinally associated with incident physical performance limitations and disability in a large population-based sample.
Methods This was an 8-year prospective study using data collected as part of the Osteoarthritis Initiative. Participants were community-dwelling adults with knee osteoarthritis or at high risk for this condition. Diagnosed CVD was self-reported. Physical performance was assessed with measures of chair stand
time and gait speed, whereas disability was assessed
with the Western Ontario and McMaster Universities
Osteoarthritis Index (WOMAC). Longitudinal associations between CVD and changes in physical performance tests (chair stand time and gait speed) and disability score were analyzed using generalized linear models with repeated measurements.
Results The analyzed sample comprised 4796 adults
(mean age 61.2 years, 58.5% female), of whom 313
people (6.5%) reported CVD at baseline. During
8 years of follow-up, after adjustment for 11 potential
confounders measured at baseline, those with CVD
experienced a worse profile in chair stand time over
the 8-year follow-up period than those without CVD
(p= 0.006).
Conclusion In a cohort of middle-aged and older
adults with knee osteoarthritis or at high risk for this
condition those with CVD experienced a worse profile
in chair stand time over the 8-year follow-up period
than those without CVD; however, CVD was not significantly associated with an increased incidence of
poor gait speed and disability over 8 years of followup. Importantly, no associations were observed when
utilizing propensity score matching.
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Citation
Veronese N., Stubbs B., Jackson S., Koyanagi A., Noventa V., Bolzetta F., Cester A., Soysal P., Maggi S., López-Sánchez G., et al., -Prospective associations of cardiovascular disease with physical performance and disability : A longitudinal cohort study in the Osteoarthritis Initiative.-, Wiener klinische Wochenschrift, 2019