Person: OKYALTIRIK, FATMANUR
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Publication Open Access [Relationship between symptoms of obstructive sleep apnea syndrome and traffic accidents in the city drivers].(2013-01-01) Akkoyunlu, MUHAMMED EMİN; KART, L; ULUDAĞ, M; Bayram, MEHMET; ALISHA, G; ÖZÇELIK, H; Karaköse, FATMANUR; SEZER, M; AKKOYUNLU, MUHAMMED EMİN; BAYRAM, MEHMET; OKYALTIRIK, FATMANURIntroduction: There is a high tendency for traffic accidents in patients with obstructive sleep apnea syndrome (OSAS). Thus it's recommended to investigate OSAS symptoms before certification of professional drivers. However, to what degree OSAS symptoms predict traffic accidents is not clear. We aimed to investigate the relationship between OSAS symptoms and traffic accidents. Materials and methods: Five hundred twenty bus drivers working at Istanbul Electricity, Tramway and Tunnel (IETT) general management were randomly selected. Berlin questionnaire was applied which included demographic data, accident ratios, total duration in profession, duration of working in a day and OSAS symptoms. Epworth sleepiness score (ESS) test was applied to assess day time slepiness. Results: All drivers were male. Snoring were present in 324 (65.7%) of participants. Traffic accident history were present in 259 (49.7%) of drivers. Significant relationship was present between traffic accident and only daytime sleepiness among the OSAS symptoms. The mean of accident/year ratio of all participants were 0.092. Mean of ESS was 7.3 ± 3.2 for all participants. There is a positive correlation between ESS and accident/year ratio (r= 0.57, p= 0.012). Conclusion: Only daytime sleepiness among OSAS symptoms is related with traffic accident. The questioning of OSAS symptoms alone is inadequate to estimate traffic accident risk. Thus further consideration more than symptom questioning is needed at phase of authorization of professional drivers to detect OSAS.Publication Open Access COVİD-19 infection in a membranous nephropathy patient treated with rituximab.(2020-09-04T00:00:00Z) Elcioglu, Omer Celal; Artan, Ayse Serra; Mirioglu, Safak; Gursu, Meltem; Durdu, Bulent; Koc, Meliha Meric; Okyaltirik, Fatmanur; Gultekin, Mehmet Ali; Kazancioglu, Rümeyza; ELÇİOĞLU, ÖMER CELAL; MİRİOĞLU, ŞAFAK; GÜRSU, MELTEM; DURDU, BÜLENT; MERİÇ KOÇ, MELİHA; OKYALTIRIK, FATMANUR; GÜLTEKİN, MEHMET ALİ; KAZANCIOĞLU, RÜMEYZAWhile COVID-19 pandemic continues to afect our country and most countries in the world, we have to make some changes both in our social life and our approach to healthcare. We have to struggle with the pandemic on one hand and also try to follow up and treat our patients with chronic diseases in the most appropriate way. In this period, one of our group of patients who are challenging us for follow-up and treatment are those who should start or continue to use immunosuppressive therapy. In order to contribute to the accumulation of knowledge in this area, we wanted to report a patient who was followed up with the diagnosis of COVID-19 and had been administered rituximab very recently due to a nephrotic syndrome caused by membranous nephropathy.Publication Open Access [The frequency and properties of REM related obstructive sleep apnea among the patients with mild related obstructive sleep apnea].(2013-01-01) Kutbay, Özçelik; Akkoyunlu, MUHAMMED EMİN; BOSTANLı, P; Bayram, MEHMET; ATAHAN, E; SEZER, M; Karaköse, FATMANUR; KART, L; AKKOYUNLU, MUHAMMED EMİN; BAYRAM, MEHMET; OKYALTIRIK, FATMANURHafif obstrüktif uyku apneli hastalarda REM ile ilişkili obstrüktif uyku apne sıklığı ve özellikleri Giriş: REM ile ilişkili obstrüktif uyku apne (OUA), “Hafif ve orta OUA olgularında daha fazla görülmesi nedeniyle uykuda solunum bozuklukları spektrumunun erken bir işareti midir?” yoksa “Tamamen ayrı bir antite midir?” sorusuyla araştırmacıların son zamanlarda oldukça dikkatini çekmektedir. Bu çalışmada, hafif OUA tanılı hastalar arasında REM ile ilişkili OUA hastalarının sıklığını ve diğer hafif OUA tanılı hastalardan farkını görmek; ayrıca REM ile ilişkili OUA hastalarında gündüz aşırı uykululuk ile apne ilişkisini değerlendirmek amaçlanmıştır. Materyal ve Metod: 1 Ağustos 2010 ile 29 Şubat 2012 tarihleri arasında Bezmialem Vakıf Üniversitesi Uyku Laboratuvarında polisomnografi tetkiki yapılan toplam 1267 hasta arasından, 134 hafif OUA [Apne hipopne indeksi (AHİ)= 5-15] tanılı hasta retrospektif olarak değerlendirildi. REM AHİ/non-REM AHİ ≥ 2 olan ve non-REM AHİ < 15 olanlar; REM ile ilişkili OUA olarak kabul edildi. Bulgular: Toplam 134 hafif OUA tanılı hastadan 80 (%59)’i REM ile ilişkili OUA olarak değerlendirildi. REM ilişkili OUA ve diğer hafif OUA’lılar yaş, cinsiyet, gündüz aşırı uykululuk, beden kitle indeksi, boyun çevresi ve ek hastalık varlığı açısından karşılaştırıldığında; REM ile ilişkili OUA grubunda yalnızca yaş ortalaması anlamlı olarak düşük bulundu. REM ile ilişkili OUA grubunun %87.3’ünde REM AHİ 15’in üzerinde; %39.3’ünde 30’un üzerindeydi. REM ile ilişkili OUA olgularında; REM AHİ ile gündüz aşırı uykululuk semptomu arasında anlamlı ilişki saptanmadı (p= 0.81). Sonuç: Hafif OUA olguları arasında, REM ile ilişkili OUA grubunun yaş ortalamasının daha düşük olması, REM OUA’nın “uykuda solunum bozuklukları spektrumunun erken bir işareti” olabileceğini düşündürebilir. Bu grup hastaların klinik takibinin bu sorunun cevabı açısından yararlı olacağı kanısındayız.Publication Metadata only Investigation of drug-related problems in hospitalized patients with respiratory diseases: a randomized controlled trial(2022-11-25) Bektay M. Y.; Sancar M.; Okyaltırık F.; Durdu B.; İzzettin F. V.; BEKTAY, MUHAMMED YUNUS; OKYALTIRIK, FATMANUR; DURDU, BÜLENT; İZZETTİN, FIKRET VEHBIPublication Metadata only Göğüs Hastalıkları ve Teletıp telesağlık(Istanbul University, 2022-04-01) Gökbulut N.; Okyaltırık F.; OKYALTIRIK, FATMANURPublication Open Access Identification of Drug-Related Problems and Investigation of Related Factors in Patients with COVID-19: An Observational Study(2022-12-01) Bektay M. Y.; Sancar M.; Okyaltırık F.; Durdu B.; İzzettin F. V.; BEKTAY, MUHAMMED YUNUS; OKYALTIRIK, FATMANUR; DURDU, BÜLENT; İZZETTİN, FIKRET VEHBIObjective: Clinical prognosis of coronavirus disease-19 (COVID-19) may be severe and unexpected. Patients may quickly progress to respiratory failure, infections, multiple organ dysfunction, and sepsis. The main objective of this study is to investigate the drug-related problems of patients with COVID-19 and related factors. Method: A prospective observational study was conducted on patients with COVID-19 between September 2020 and May 2021. Patients’ demographics, comorbid diseases, prescribed medicines and laboratory findings were recorded. Drug-related problems (DRPs) were identified by a clinical pharmacist according to recent guidelines, UpToDate® clinical decision support system and evidence-based medicine. Results: The median age of 107 patients was 64 and 50.46% of them were male. The median number of comorbidities was 3 (2-4) per patient. The majority of the patients had at least one comorbidity (88.79%) other than COVID-19 and the most frequent comorbidities were hypertension, diabetes mellitus and coronary artery disease. The total number of DRPs was recorded as 201 and at least one DRP was seen in 75 out of 107 patients. The median number of DRPs was 2 (0-8). In multivariate model, number of comorbidities (odss ratio (OR)=1.952; 95% confidence interval (CI)=1.07-3.54, p<0.05, number of medications (OR=1.344; 95% CI=1.12-1.61, p<0.001), and serum potassium levels (OR=5.252; 95% CI=1.57-17.56, p<0.001) were the factors related with DRP. Conclusion: This study highlights the DRPs and related factors in patients with COVID 19 in hospital settings. Considering unknown features of the infection and multiple medication use, DRPs are likely to occur. It would be beneficial to consider the related factors in order to reduce the number of the DRPs.Publication Open Access Does hormonal control obviate positive airway pressure therapy in acromegaly with sleep-disordered breathing?(2013-11-01) Akkoyunlu, MUHAMMED EMİN; Ilhan, MAHMUT MUZAFFER; Bayram, MEHMET; Tasan, ERTUĞRUL; YAKAR, Fatih; OZCELIK, Hatice Kutbay; KARAKOSE, Fatmanur; Kart, Levent; AKKOYUNLU, MUHAMMED EMİN; İLHAN, MAHMUT MUZAFFER; BAYRAM, MEHMET; TAŞAN, ERTUĞRUL; OKYALTIRIK, FATMANURAcromegaly is a disease in which uncontrolled release of growth hormone occurs after closure of epiphyseal plates, causing changes in the body that can lead to sleep disordered breathing (SDB). No definite guidelines regarding the treatment of SDB in acromegaly are available. In this study, we aimed to investigate the prevalence of SDB in acromegaly and whether hormonal control alters the necessity of positive airway pressure (PAP) therapy in acromegaly patients with SDB. Methods: Forty-two acromegaly patients were included in the study and divided into two groups according to disease status, i.e., active or well controlled. All patients underwent polysomnography. Fourteen patients with active acromegaly were diagnosed with SDB and were evaluated for PAP therapy with polysomnography both before and 6 months after disease control was achieved. Results: Sleep-disorder breathing was diagnosed in 22 of 42 patients, 7 of 20 patients with controlled-disease and 15 of 20 patients with active diseases. There were significant reductions in respiratory disturbance index (RDI), apnea index, desaturation index, central apnea number, and rapid eye movement-phase RDI at the control polysomnography. Initially, PAP therapy was indicated in 12 of 14 patients and PAP therapy indication held in 11 patients after acromegaly control was achieved. Conclusion: Our study revealed that over half of patients with acromegaly had SDB. Furthermore, SDB severity decreases with acromegaly treatment; however, this decrease does notPublication Open Access The successful management of an elderly Covid-19 infected patient by plasmapheresis.(2020-08-25T00:00:00Z) Akkoyunlu, YASEMİN; Okay, G; Cetin, G; Bolukcu, S; Karaaslan, K; Ogun, H; Okyaltirik, F; Durdu, B; AKKOYUNLU, YASEMİN; ÇETİN, GÜVEN; OKAY, GÜLAY; DURDU, BÜLENT; OKYALTIRIK, FATMANUR; KARAASLAN, KAZıMPublication Metadata only The effect of incentive spirometry in addition to comprehensive chest physiotherapy on length of hospital stay and hemodynamic responses in patients with COPD exacerbation(2023-09-01) Kulli H. D.; Kaya M.; Ucgun H.; Zeren M.; OKYALTIRIK F.; GÜRSES H. N.; OKYALTIRIK, FATMANUR; GÜRSES, HÜLYA NILGÜN