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Publication Open Access Adheziv kapsülitli hastalarda ağrının fonksiyonellik, kinezyofobi, uyku kalitesi ve yaşam kalitesine etkisi(Bezmialem Vakıf University, 2017) Bilge, Ceren; Özyılmaz, Semiramis50 patients who had adhesive capsulitis diagnosed and shoulder pain complained were included in our study to investigate the relationship between pain, functionality, kinesiophobia, quality of sleep and quality of life. Visual Analog Scale (VAS) was used to determine the pain level, The Disabilities of the Arm, Shoulder and Hand (DASH) was used to assess functionality, Tampa Scale of Kinesiophobia (TSK) was used to determine the kinesiophobia level, Pittsburgh Sleep Quality Index (PSQI) was used assess the sleep quality and quality of life was assessed by the Nottingham Health Profile (NHP). There was a significant correlation between pain severity and TSK, DASH total score, some sub-parameters of PSQI and NHP (p<0,05). There was a significant correlation between DASH score and some sub-parameters of PSQI scores (p<0,05). Also, there was a significant correlation between DASH score and all quality of life sub-parameters except NHP sleep (p>0,05). There was a significant correlation between TSK score and all sub-parameters of NHP except NHP pain and some sub-parameters of PSQI (p<0,05). Also, there was a significant correlation between PSQI and some sub-parameters of NHP (p<0,05). As a result, this study showed that the common symptom of pain in adhesive capsulitis patients had a negative effect on functionality, kinesiophobia, quality of sleep and quality of life.Publication Open Access Adölesan İdiyopatik Skolyozlu Çocuklarda Core Stabilizasyon Eğitiminin Solunum Parametreleri, Periferik Kas Gücü, Denge, Fonksiyonel Kapasite ve Yaşam Kalitesi Üzerine Etkisi(Bezmialem Vakıf University, 2019) Yıldırım, Sefa; Özyılmaz, SemiramisThe three-dimensional deformity of the vertebrae with lateral flexion in the frontal plane of 10 ° and in the axial plane and the flattening components in the physiological curve in the sagittal plane is defined as scoliosis. 80% of the structural scoliosis is idiopathic scoliosis. Adolescent idiopathic scoliosis (AIS) is a variant of idiopathic scoliosis occurring from the onset of puberty (above 10 years of age) until the growth plates are closed. Conservative and surgical treatment options have been reported in the treatment of AIS. Conservative treatment includes observation, exercise and orthotic options. The primary purpose of conservative treatment in AIS is to correct secondary damage including back pain, respiratory problems, balance problems and cosmetic deformations by preventing progression of the curve and improving quality of life. Specific exercise methods are used in conservative treatment. Core Stabilization exercises are also one of these methods. The aim of this study was to investigate the effects of Core Stabilization training on respiratory parameters, peripheral muscle strength, balance, functional capacity and quality of life in AIS patients. The study included 30 children aged 10-20 years with AIS who were randomly assigned to experimental and control groups. Pulmonary function test (PFT), respiratory and peripheral muscle strength measurement, 6 min walk test (6 MWT) and Biodex Balance System® device and postural stability and stability limits were applied to all patients. Exercises given to the experimental and control groups were administered under the supervision of a physiotherapist for 1 week, in the home 6 days a week for 8 weeks. Traditional scoliosis exercises were given to the control group. In addition to the traditional scoliosis exercises, the core exercise program was included for training group. At the end of eight weeks, evaluations were repeated. SPSS Statistics 21.0 program was used for data analysis. The significance level was accepted as p <0.05 for all analyzes. At the end of the 8th week, in the training group, trunk rotation angle, forward and side tilt angles, respiratory function test parameters % FVC and% FEV1 values, respiratory muscle strength values (MIP, MEP), some parameters in the stability test stability parameters, hand grip and quadriceps muscle strength, functional capacity, cosmetic deformity perception score and some parameters of quality of life. In the control group, statistically significant improvement was found in forward and side bending angles, MIP values, stability parameters in stability test, quadriceps muscle strength, functional capacity and some sub-parameters of quality of life. When the training and control groups were compared, some improvement was observed in the education group in some respiratory parameters and in the perception of cosmetic deformity. Considering the literature and the results of our study, it was concluded that Core Stabilization exercises could be applied to AIS patients and added to routine physiotherapy program. keywords: adolescent idiopathic scoliosis, core stabilization exercises, pulmonary function test, respiratory muscle strength, peripheral muscle strength, cosmetic deformity perception, quality of lifePublication Metadata only AFAD İstanbul Arama Kurtarma Birliğinin Ekip Çalışmasına Yatkınlığı(2019) Demirbaş, Elif; Erdoğan, ÖzcanThe AFAD search and Rescue Association is based on volunteering and dedication in terms of working conditions. The human factor has an important place in the success of this institution. AFAD employees, who have a sense of commitment to their institutions, take great responsibility in providing superior services to organizations. It was also thought that the satisfaction of the employees, their commitment to their organization and the support of the organization will increase the quality and efficiency of the service the organization aims to provide. This research was carried out on a descriptive and cross-sectional basis in order to determine the relationship between AFAD Istanbul search and Rescue union employees and organizational commitment and to take necessary measures against the problems present in the institution. The research was carried out with 71 employees working in search and rescue unit of Disaster and Emergency Directorate in Istanbul between 02.11.2018 - 01.01.2019. Data were collected using Descriptive Information Form and Organizational Commitment Scale. Descriptive statistics were used to evaluate the data. The average age of the participants was 38.89 ± 6.32 years and 91.5% were male. 23.9% of them have associate degree and 67.6% of them have bachelor's degree. 81.7% are married. 50.7% have been working in the current institution for less than 10 years. Total working time of 46.5% is less than 12 years. 14.1% graduated from agriculture. 63.3% are employed as search and rescue technicians. Employees considered their organizational commitment to be 25.4% very good and 22.5% good. 54.9% said they faced a problem related to organizational commitment. The average point of the Organizational Commitment Scale was determined 3.07 ± 0.20. The average point of Organizational Commitment Scale of those whose total working period is 12 years or more was found to be statistically higher than those with a total working time of under 12 years (p:0,048; p<0,05). The average point of Organizational Commitment Scale of those who did not encounter a problem about organizational commitment was found to be statistically higher than those who encounter a problem about organizational commitment (p:0,015; p<0,05). It wasn't determined statistically significant difference between Organizational Commitment and age, gender, marital status, education level and working time in the current institution. It was found that the employees evaluated the status of having organizational commitment as good but faced with problems related to organizational commitment. At the same time, it was concluded that employees with a high level of organizational commitment can respond to the situation in a prepared and effective without stress manner in the event of a disaster.Publication Metadata only AFAD İstanbul Arama Kurtarma Birliğinin Örgütsel Bağlılığı(2019) Özkar, Yalım; Erdoğan, ÖzcanThis research was conducted descriptively and cross-sectionally in order to determine the relationship between AFAD Istanbul Search and Rescue Association employees and teamwork tendency. The research was carried out with 67 employees working in Search and Rescue Association of Disaster and Emergency Directorate in Istanbul between 02.11.2018- 01.01.2019. Data were collected by using the Descriptive Information Form and the Teamwork Tendency Scale. Descriptive statistics were used to evaluate the data. The average age of the participants was 39.58 ± 5.81 and 89.6% were male. 23.9% of them have associate degree and 70.1% of them have bachelor degree. 77.6% are married. 52.2% have been working in the current institution for more than 15 years. 53.7% of the total working time is over 15 years. 19.4% are graduates from agriculture department. 58.2% are employed as search and rescue technicians. 29.9% of the employees evaluated their own teamwork as very good and 31.3% as good. 53.7% said they had a problem with teamwork. The average point of the trust subscale of those aged 40 and under, was significantly determined higher than those over 40 years of age (p:0,020; p<0,05). Average point of sub-dimension of diagnosing and analyzing the problem of high school / associate degree graduates was found to be statistically higher than bachelor's and above graduates (p:0,039; p<0,05). High internal motivation subscale average point of high school / associate degree graduates were found to be statistically higher than those of bachelor's and above graduates (p:0,024; p<0,05). The average point of responsibility subdimension of those who think that teamwork is very good was found to be significantly higher than those who think that it is medium and lower (p:0,015; p<0,05). The average point of cooperation and teamwork sub-dimension of those who think that teamwork is very good, was found to be significantly higher than those who think that teamwork is moderate and under (p: 0.001) and good (p: 0.020). (p<0,05; p<0,01). High internal motivation subscale point of those who think that teamwork is very good, was found to be significantly higher than those who thought that the teamwork was moderate and below (p: 0.019) and good (p: 0.029). (p<0,05). The average point of leadership, persuasion, perseverance sub-dimension of those who think that teamwork is very good, was found to be significantly higher than those who thought that teamwork was was moderate and below (p: 0.001) and good (p: 0.01). (p<0,01). The average point of cooperation and teamwork subscale scores of those who encountered problems during the teamwork was found to be significantly higher than those who did not encounter the problem (p:0,017; p<0,05). It was found that the employees evaluated the status of being a team member as good but encountered problems during the team working. xiv In this study, it is concluded that teamwork is vital for the measures to be taken in case of disasters and emergencies and for interventions to be made at the event.Publication Open Access Ağır Vasıta Sürücülerinde Ağrı, Postür, Uyku Kalitesi, Yorgunluk, Stres ve Yaşam Kalitesinin Değerlendirilmesi(2019) Yavuz, Yavuzhan; Özyılmaz, SemiramisIn our country, freight and passenger transport is largely used as a result, truck and bus drivers face an extreme workload. As a result of this intensive workload, drivers face a high risk of musculoskeletal problems, stress, fatigue and sleep quality. This study was carried out to investigate the differences between pain, postural changes, sleep quality, fatigue, stress and quality of life in urban and intercity heavy vehicle drivers. A total of 76 drivers 42 of them in cities including 17 (%40) of them are trucks, 25 (%60) of them are buses, 34 of them in intercities including 12 (%35) of them are trucks, 22 (%65) of them are buses participated in the study for at least 5 years, using 5-8 hours per day, without surgery and without spinal problems. The individuals pain assessments with McGill Melzack pain survey and visual analogue scale, postural changes by New York posture method, manual muscle tests and elasticity evaluations, hand grip forces with Baseline Smedley Digital Hand Dynamometer® device, sleep quality by Pitsburgh Sleep Quality Index, daytime sleepiness levels by Epworth sleepiness scale, fatigue severities by Fatigue Severity Scale, stress levels by Perceived Stress Scale and quality of life assestments by Nothingham Health Profile. SPSS v.20.0 program was used for data analysis. The results were considered significant with P-values<0,05. There was no statistically significant difference between the groups when the postural changes, pain complaints and pain severity of the drivers who used urban and urban heavy vehicles were compared (p>0,05). While our drivers had similar sleep quality, intercity drivers had higher daytime sleepiness compared to city drivers (p = 0,034). It was found that intercity drivers felt more severe than urban drivers (p <0,05). It was observed that the perceived stress level of urban drivers was higher (p <0,05) and this was related to cigarette consumption (p = 0,010) and food consumption (p = 0,015). When we look at the quality of life in urban and intercity drivers there is no difference but was found to be worse emotional reaction sub-parameter in city drivers (p <0.05) and to be worse to be worse energy sub-parameter in intercity (p = 0.004) drivers. As a result of our study, it was observed that both urban and intercity heavy vehicle drivers had similar problems with musculoskeletal system, the drivers who were driving by city were exposed to more stress, and the drivers who were by intercity felt more tired. Keywords; truck, bus, quality of life, pain, posture, sleep, fatigue, stressPublication Open Access Ameliyathane hemşirelerinin delici kesici aletler ile yaralanma durumu, nedenleri ve önlemleri(Bezmialem Vakıf Uniersity) Dağcı, Mahmut; Sayın, YazileIntroduction: Penetrators and sharps injuries, PSI is a factor affecting the healthcare workers, is seen high among operating room nurses. This research was planned and conducted to examine the conditions and precautions that operating room nurses cause to PSI. Method: The descriptive and cross-sectional study was conducted between January 2017-May 2018 in istanbul european side with 463 volunteer nurses in 27 different hospitals. Operating rooms had at least 10 nurses and were compliance with the Turkish Standards Institute Clean Rooms Standard. The data collected with two data forms which prepared with knowledge of literature. IBM SPSS 22.0 used for data analysis and P<0.05 was significance value. Findings: Participants were 18-61 years old, (avg.35.9 +- 0.84), 63.7% had bachelor degree and above, 80.8% had nurse title, 68.9% said they had PSI. There were significantly different for PSI (p<0.05) women, married and had low educational level, working in university hospitals with deep invasive intervention and using protective equipment. Participants reported that 54.8% of the injuries were performed in the right hand and primary cause was exchanging instruments between nurse and surgeon, secondary was assisting surgeon. Most of the participants (37.1%)were injured by the suture material.After the injury, 83.0% of the participants were made right attempt to the wound. 26.6% of the participants, come across to infected PSI, while only 60.2% reported it. 71.4% who didn't report said, reporting wasn't working and wasn't significant. Conclusion: Personal and occupational characteristics of health workers working as nurses with inadequate physical and environmental factors of the operating theater are effective in the high PSI rate.Publication Open Access Anti-oksidan doğal bileşiklerin kemoterapi ajanı paclitaxel ile birlikte nano misellere yüklenmesinin etkinlik ve toksisite profili açısından in -vitro ortamda gözlenen olası değişiklikler(2019) Öztenekeci, Burcu; Bahadori, FatemehChemotherapeutic agents used in chemotherapy treatment not only affect cancer tumors, but also can cause toxic effects in healthy areas. These substances show side effects from time to time due to their oxidation effect. From this point of view, it is sometimes recommended that patients consume antioxidant natural products during chemotherapy in cancer treatment. However, these antioxidant substances may reduce the oxidation effect of the chemotherapy agent at the cancer tumor site and prevent the chemotherapy agent from acting fully. This issue should be clarified. From this point, the antioxidant effect of curcumin, quercetin and rosmarinic acid compounds were applied to cancer cells together with chemotherapy agent paclitaxel and the effect of this agent was investigated. For this purpose, the natural antioxidants compounds were loaded into nano-carriers and the effect of paclitaxel on breast cancer cells was investigated. The reason for the loading of natural antioxidants in the nano-carrier is that these substances can be applied to the cells at a high rate by removing their low solubility property in water. To this end, poly lactide co-glycolide (PLGA) nano-micelles were used. The water-soluble commercial form of Paclitaxel was applied to the cells. The nano-formulation of each antioxidant was prepared separately using the o/w method. Briefly, the antioxidant and PLGA were dissolved together in acetone and slowly dropped into water containing the surfactant. The organic solvent was removed at room temperature by stirring overnight. The size of the nanofomulations obtained were determined by Dynamic Light Scattering (DLS) method. The antioxidants were loaded into the nao-carrier with increasing concentrations, and the highest concentration with no aggregate, ie the formulation in which the entire compound was loaded into the micelle, was considered as the optimized formulation. The concentration of paclitaxel equal to the IC 50 value was applied to MCF-7 human breast cancer cells with various concentrations of nano-antioxidants and changes in cell viability were observed. Cell viability was measured by Sulforhodamine B assay. In addition, nano-anti-oxidant was applied to the cells together with paclitaxel, 1 hour before paclitaxel and 1 hour after paclitaxel, and the effect of time of administration on the results was investigated. In conclusion, it was observed that curcumin significantly reduced the anti-tumor effect of Paclitaxel. Quercetin reduced the anti-tumor effect of paclitaxel in a dose-dependent manner. There was no significant effect of rosmarinic acid. It was observed that the application time had no function on the change of these effects. Ultimately, the bioavailability of antioxidant and its concentration in the blood will remain unknown unless the concentration of the antioxidant in the blood circulation is known. This will cause the unknown direction of the natural antioxidant on affecting the effect of chemotherapy on the tumor site. From this it can be clearly concluded that antioxidants should not be used during cancer treatment unless the xiv effect of the anti-oxidant on the chemotherapy agent and ultimately its negative impact on the growth of the cancer tumor is fully understoodPublication Open Access Bezmialem Vakıf Üniversitesi Hastanelerinde Çalışan Hemşirelerin Afetlere Hazır Oluşluluk Durumları(2019) Zeren, Hasret; Erdoğan, ÖzcanThis study was accomplished descriptively and cross-sectionally to determine the preparedness of the nurses working in Bezmialem Vakif University Hospitals. The study was carried out with a total of 430 nurses including 360 nurses working at Bezmialem Vakif University Medical Faculty Hospital (Vatan Campus) and 70 nurses working at Bezmialem Vakif University Dragos Hospital between the dates of 01.11.2018 - 01.02.2019. Data were collected using the Descriptive Information Form and the Basic Competence Scale of Nurses in Preparedness to Disasters. Descriptive statistics were used to evaluate the data. The average age of the nurses participating in the study was found to be 26,06±6,05 and the average duration of the study was 6,24±5,86. It was found that 76.8% of the nurses were female, 64.8% of them were single, 38% of them were high school graduates, 31.7% were associate degree graduates and 28.2% were bachelor graduates. It was determined that 53.5% of the nurses were working as service nurses and 60.6% of them did not receive any training on disasters. 69% of nurses before the disaster, 90.1% of them during the disaster, 93.7% of them after the disaster stated that nurses have a role after disaster. The average point of the nurses' preparedness for disasters was 5,03±2,38 (min-max: 0-10). Hospital disaster plan knowledge status perception point average was found to be 4,27±2,53 (. (Min-max: 0-10). It is determined that disasters which the nurses see as highly probable as earthquakes and traffic accidents with 63.4% and disaster preparedness course is the most necessary course with 47.9% as disaster management course. It is found that the average point of Basic Competence Scale of Nurses in Preparedness to Disasters was 141.46 ± 32.48, the lowest subscale point was 11.49 ± 3.42 with critical thinking skills and the highest subscale point was 48.23 ± 12.21 with technical skills. It is found a positive and weak correlation between critical thinking skills and disaster preparedness (r = 0.170). A positive and weak correlation was found between special diagnostic skills and disaster preparedness (r = 0.197). The median values of occupational groups were found to differ from the bachelor graduate nurses according to the critical thinking skills sub-dimension (p = 0.027). In the study, the preparedness level of the nurses for disasters was found to be "moderate".Publication Open Access Bozulmuş Açlık Kan Şekeri ve İnsülin Direnci Olan Hastalarda Çinko ve Bakır Metabolizmasının Araştırılması(Bezmialem Vakıf Üniversity, 2020) Sarıkaya, Alime; Selek, ŞahbettinDiabetes mellitus is a worldwide health problem in recent years. Diabetes is a disease that makes long-term defects in lipid, carbohydrate and protein metabolism. Also insulin secretion disorders, insulin resistance and impaired fasting glucose metabolism are important factors that lead individuals to diabetes. The role of zinc and copper trace elements in the etiology of diabetes mellitus (DM) has not been clarified in recent studies. The aim of this research was to investigate the relationship between impaired fasting glucose (IFG) and increased insulin resistance (IR) and trace elements such as Zn and Cu which have important roles in metabolism. There ara four groups which are IFG, Homa-IR, Trype2 DM and control in the study. IFG group consisted of fasting glucose levels according to WHO criteria, IR group was Homa-IR ≥ 2.5, Type2 DM was diagnosed and healthy individuals without IR also fasting glucose level < 100 mg/dL were control group. Control and Type2 DM groups with serum with IFG, IR and control group, Type2DM patients were compared with the control group. Zn and Cu trace element levels were analyzed in all samples. The difference between the groups was calculated using student t-test and the relationship between them was calculated using Pearson Correlation Coefficient. According to the results, there was an extremely significant decrease in Zn level in IFG and Type2 DM groups (p<0.05), while an extremely significant increase in Cu was found in IR group (p<0.05). As a result, it was observed that the changes in Zn and Cu levels were an important factor in the metabolism that predisposes to Type2 DM without separating IR or IFG. Also as a result, it is seen that the incidence of Type2 DM increases with age. It is thought that prediabetes patients should take precautions at early age and period will be an important key to slow down the process leading to diabetes. The low level of zinc and high level of copper in the metabolism of Type2 DM patients indicates that the measures to be taken in prediabetes. In prediabet, Zn supplementation is thought to have an important role in decreasing plasma glucose level and preventing progression to Type2 DM by taking a regulatory role in Zn and Cu levels. Key words: Trace elements, zinc, copper, insulin resistance, impaired fasting glucose, diabetes mellitus.Publication Open Access Çocuk yoğun bakımdaki refakatçi annelerin kaygı, depresyon ve yaşam kalitesinin incelenmesi(Bezmialem Vakıf University, 2017) Çabuk, Burcu; Kostanoğlu, AlisThis study was planned to investigate the factors affecting anxiety, depression and quality of life of companion mothers of children who lived in Bezmialem Vakıf University Medical Faculty Children's Health and Diseases Department of Child Intensive Care and Child Care. Twenty mothers were evaluated in each group; A total of 40 people were included in the survey. Attendanting mothers were enrolled in Beck Depression Inventory (BDE), Nottingham Health Profile (NSP), Spielberger Trait Anxiety Inventory (STAI). For the statistical analysis, the SPSS program version 21 (Statistical Package for the Social Sciences) analysis program was used. Data from children's intensive care attending mothers and attending mothers; Mean, number and percentage distributions were evaluated by Student-t and Kruskal Wallis tests. Statistical significance level was accepted as p <0.05. Three children (neurological, surgical, respiratory failure) were divided into three subgroups according to the reasons of admission. One-way analysis of variance (ANOVA) test technique was applied to compare the anxiety, depression and quality of life levels of the mothers in these subgroups with each other. There was no statistically significant difference in the anxiety, depression and quality of life levels of the mothers between the disease groups (p> 0.05) when the anxiety, depression and quality of life measures of the children of different disease groups were compared with the one way ANOVA in the independent groups. There was a statistically significant difference in the level of anxiety, depression and quality of life of the attendanting mothers in the intensive care unit compared to those of the attendanting mothers (p <0.001). We think that the attendanting mothers in the intensive care unit are more vulnerable to the situation of their children, more complex environment, more invasive procedures.Publication Metadata only Dental implant cerrahisi uygulanan hastalarda preoperatif bilgilendirilmelerin anksiyete ve ağrı seviyeleri üzerinde etkisi / The effect of preoperative information on anxiety levels and pain in dental implant surgery patientsSHANI DAHHAN, AMEER; KAZANCIOĞLU, HAKKI OĞUZGiriş: Teknolojinin gelişmesiyle günümüzde herkes sosyal medya aracılığı ile diş hekimliği ile ilgili video izleme şansına sahip olmuştur. Dental implant yerleştirme operasyonu ile ilgili preoperatif bilgi edinilmesi cerrahi işlem videolarının bir çok insane üzerinde korkutucu etki bırakması sebebiyle işlem esnasındaki anksiyete seviyesini arttırabilmektedir. Bu çalışmanın amacı, preoperative vidseo izlemenin ve implant cerrahisi videosu izlemenin anksiyete seviyesi ve ağrı üzerine etkisinin incelenmesidir. Materyal ve metod: Bu çalışma temel olarak prospektif, kesitsel, gözlemsel bir araştırmadır. Bu çalışmada dental implant uygulanan 60 vaka üzerinde anket uygulanmıştır. Vakaların tamamı üç gruba ayrılmıştır: iki çalışma grubu ( Grup 1, sözlü olarak temel bilgi verildi; Grup 2 (çalışma grubu) sözlü olarak temel bilgisi verilmiş ve implant cerrahisi videosu izletilmiştir.) ve kontrol grubu ( operasyon prosedurunu ve iyileşmeyi içermeyen temel bilgiler sözlü olarak verilmiştir.) Anksiyete seviyesinin ölçülmesi için Dental Anksiyete Skalası (DAS), Spielberger‟s State-Trait Anksiyete Envanteri testi ve ağrının değerlendirilmesi için Visual Analogue Scale (VAS) kullanılmıştır. Ġstatiksel analizler SPSS 16.0 yardımı ile yapılmıştır. Bulgular: Grup 2 hastalarının anksiyete seviyeleri operasyon öncesinde anlamlı derecede yüksektir. Ayrıca, DAS‟da en anlamlı artış bu grupta gözlenmektedir. Sonuç: Preoperatif multimedia bilgisi implant cerrahisi yapılacak hastanın anksiyete seviyesini arttırmaktadır.Publication Open Access Dental implant tedavisi seçiminde medyanın etkisi / The effect of media on choosing dental implant treatment(Bezmialem Vakıf University, 2018) Sayın Varol, Hilal; Tuncel, İlkinMedia is the most important organization form of communication process. Means of communication as newspaper, magazine, radio, television are called media. Nowadays people become more conscious in the matters about health and with this, the introduction of new treatments are more often take place in the media. With the improvement of media, doctors from various branches and health agencies can reach too many people via the social media accounts they take like Facebook/Instagram/Twitter. In the light of these developments, the aim of the study is detecting whether patients are affected by the news and sharing's they see at media while choosing the dental implant treatment. In our study the questionnaire is carried out to 200 patients attended to Bezmialem Vakıf University, Faculty of Dentistry with the complaint of minimum one tooth lost, who knows about dental implant treatment and didn't have dental implant treatment before and who are between 18-65 years old. After giving information about the survey, the questionnaire forms were given to the patients and provided to fill it themselves. For the probability of misunderstanding one observer was made available. In the first part of the survey demographic information were asked, in the second part questions were asked with a Likert scale of 5 to evaluate the preferences of the patients about dental implant related issues. In Likert scale questions in every line, only one choice wanted to be selected from (1) no matters to (5) very important. Pearson's Chi-squared test was used to determine whether the age, gender, education, and family income levels of the participants of the questionnaire influenced their preference for dental implant treatment. The questionnaire consists of the reasons why patients choose dental implant treatment or not, and the effects of the media on dental implant, practitioner and institution choosing to perform a treatment. The media is the least effective factor when choosing dental implant treatment as well as choosing the dental implant to be applied, the dental implant practitioner, and the institution. According to the thesis results, even though the media is the most effective mass communication tool, it is the least effective factor in the preference of dental implant treatment. This result should be examined in detail. The rate of treatment rejection of those who learn the concept of dental implant from social media is higher than the rate of acceptance. The reason for this rejection is that the sharing in the social media has negative effects on the patients. Finally, nowadays, the media provides both quick and easy access to any kind of information to the producer or consumer, so they should be conscious of media usage.Publication Open Access Dikkat eksikliği ve hiperaktivite bozukluğu olan çocukların fiziksel aktivite düzeyleri / Physical activity of children with attention deficit and hyperactivity disorders(Bezmialem Vakıf University, 2019) Karadağ, Melike; Özyılmaz, SemiramisThis research was performed between 05.02.2018-20.04.2018 at primary and secondary schools that located in Bursa/Nilufer to investigate physical activity levels (PAL) of students with attention deficit hyperactivity disorder (ADHD). A total of 80 volunteer students aged between 8-14 were joined to the research. In the study group, from Cavit Caglar Secondary School 3, from Emir Koop Primery School 3, from Husnu Zuber Primery School 3, from Koc Secondary School 7, from Vahide Aktug Secondary School 3, from Ucevler Sehit Faik Gökcen Primery School 3, from Fethiye Secondary School 5, from Ozluce Private Sınav Secondary School 12 students (total 39) with attention deficit hyperactivity disorder; in the control group, from Balat Private Sınav Primery School 14, from Balat Private Sınav Secondary School 27 students (total 41) with health were taken placed. Among the students, 28 were girls where as 52 were boys. The Physical Activity Questionnaire for Children (PAQ-C) were appleid to these students, and their feeding types, healthness and family incomes were investigated as demographic records. In the study group, the ratio of girl/boy was 1/4 while the same ratio was nearly 1/1 in the control group. Students with attention deficit hyperactivity disorder were consumed more healthy food than the control group students (p<0,05). The physical activity performans were found significantly higher at the study group than the control group during the breathing times at school (Question 3), during daily free times after school (Question 5), at the weekends (Question 7), throughout the week (Question 8, Question 9) (p<0,05). In addition, the mean score of PAQ-C of the study group was significantly higher than the mean score of the control group (p<0,05). When students with attention deficit hyperactivity disorder were compared according to the types, the physical activity level was the highest in Type-II while it was the lowest in Type-I (p<0,05). As a result, the physical activity performans were found significantly high at the study group than the control group (p<0,05). Thereby we can accept the activity increase in students with attention deficit hyperactivity disorder as physical activity increase, and there is a positive relation between attention deficit hyperactivity disorder (ADHD) and physical activity level (PAL). Keywords: Attention deficit, hyperactivity disorder, children, physical activity levelPublication Open Access Diz osteoartriti olan hastalarda sağlıklı yaşam biçimi davranışları ile ağrı ve fonksiyonel durum arasındaki ilişki(Bezmialem Vakıf University, 2018) Gökşen Kılınç, Burcu; Gürses, H. NilgünThis study was planned to investigate the relationship between healthy lifestyle behaviors and pain and functional status in patients with knee osteoarthritis (OA). The study included a total of 30 patients who came to the polyclinic of a private treatment center for the study, had a knee OA diagnose and complaine of knee pain. The patients' ages ranged from 40 to 65 years. The mean age was 54.36 ± 2.85 year. Thirteen of the patients were male and 17 were female. After the demographic data of the cases were taken, physical evaluations were made. Healthy Life Style Behaviors Scale II (HLBS II) for assessing healthy lifestyle behaviors of all cases, Visual Analogue Scale (VAS) for assessing pain levels, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaires for asessing functional status were used. Statistical analysis was performed by using a Windows-based SPSS (Statistical Package for the Social Sciences) analysis program, with significance level p <0.05. There was a statistically significant correlation among resting of VAS value of patients and WOMAC total score and all subscores (p <0,05). There was a significant correlation between WOMAC total score and subscores (pain and physical function) with VAS value after active movement of the patients (p <0,05). There was no statistically significant correlation between WOMAC hardness subscore and VAS value after active movement of the patients (p> 0,05). There was a statistically significant correlation among resting VAS value of the patients and the stress management score of HLBS II total score and sub-parameters (p <0,05). There was no statistically significant correlation between resting VAS value of patients and other HLBS II subscores (health responsibility, physical activity, nutrition, spiritual development, interpersonal relations) (p> 0,05). There was no statistically significant correlation between the VAS value after active movement of the patients and the total score of the HLBS II and its all subscores (p> 0,05). There was a statistically significant correlation between WOMAC total score and stress management score of HLBS II (p< 0,05). There was no statistically significant correlation between WOMAC total score and other HLBS II subscores (health responsibility, physical activity, nutrition, spiritual development, interpersonal relations) (p> 0,05). There was no statistically significant correlation between the patients' WOMAC total score and HLBS II total score and its all subscores (p> 0.05). As a result, the functional status worsens as the resting pain or the pain after active movement increases in patients with knee OA. However, there is no correlation between healthy lifestyle behaviors and pain and functional status except between resting VAS and stres management score of HLBS II.Publication Open Access Diz üstü amputelerde vücut imajı algısının ve proteze uyumun kognitif performansa etkisi(Bezmialem Vakıf University, 2017) Gözaydınoğlu, Şüheda; Hoşbay, ZeynepThe purpose of this study was to assess the effect of body image perception and compliance with the prosthesis on cognitive performance in transfemoral amputees, and to determine the factors that can lead to possible differences. Our research has been conducted the dates between December 2016- March 2017, at Bezmialem Vakıf University. Fourty transfemoral amputee, 30 males and 10 females, who had a traumatic amputation, with the average age 37,03±9,94 years were included in this study. Participants sociodemographic, amputation-specific and prosthetics usage related informations was recorded with the General Amputee Evaluation Survey which is prepared based on literature. Participants body image perception and compliance with the prosthesis paramaters were evaluated with ABIS (Amputee Body Image Scale) and TAPES (Trinity Amputation and Prosthesis Experience Scales). The assessment of the quality of life was done by NHP (Nottingham Health Profile). MoCA (The Montreal Cognitive Assessment) has been used to determine the cognitive ability of the participants. Neuropsycological subtests has been administered by dual task method during ambulation. For statistical analysis, a Windows-based SPSS 21 analysis program was used, significance level was accepted as p<0.05). The time passed after the amputation of the participants has been determined as 12,68±9,41 years. Individuals who are included in this study has an average 10,6±8,38 years of prosthetics usage. 45% of the participants regularly participate in sportive or physical activites, 55% of them do not participate any physical activity. Depending on the type of prosthesis, %50 of the participants are using microprocessor controlled and %50 are using hydraulic prosthetic knee. There was a statistically significant correlation between the ABIS, TAPES I. part subparamaters and cognitive performance (p<0,05). The relationship between the ABIS and TAPES I. part subparameters was statistically significant (p<0,05). Satisfaction with the body image and positive compliance to prosthesis was related improved quality of life. When the participants are divided into two groups based on their prosthetic type, it showed that ABIS, TAPES I. part subparameters and NSP, cognitive performance value difference have statistically significant (p<0,05). When the same data evaluated based on participants physical activity habits, regarding to cognitive peformance; any statistically significant difference was not found (p>0,05). Our study results shows that body image perception and compliance with the prosthesis may have effect on cognitive performance. By regulating body image perception and adding psychosocial adjustment to amputee rehabilitation programs, we believe that the amputee can improve its performance in cognitive functions such as attention, memory, and orientation, which are necessary for adaptation of the acquired injury, successful use of the prosthesis and independence on activities of daily living.Publication Open Access Engelli Çocuklara Sahip Annelerin Bel Ağrısı, Yaşam Kalitesi Ve Depresyon Düzeylerinin Karşılaştırılması(2019) Ötegen, Ömer; Kostanoğlu, AlisThe aim of our study is to compare the low back pain, quality of life and depression levels of mothers with disabled children. Our study; A total of 126 mothers were included in the study. 86 mothers with 3-9 year old children with disabilities and 40 mothers with healthy children were included. Participants were divided into three groups as mothers with physical disabilities (n = 41), mothers with mentally handicapped children (n = 35) and mothers with healthy children as control groups (n = 40). Mothers with disabilities were included in the study-specific training and rehabilitation center for at least one year.The control group included mothers of children attending a kindergarten or an educational institution. The demographic data and clinical information of the patients were recorded in the form prepared by the investigator. After the demographic data of the participantswererecorded, the Oswetry Low Back Pain Disability Questionnaire (ODI) was used to assess the low back pain of the mothers. The Nottingham Health Profile (NHP) was used to assess the quality of life. To determine the level of independence of children with disabilities, Pediatric Functional Independence Measure (WEE-FİM) was used. Data were analyzed with SPSS 22 program. When the groups were compared, OBAI, NHP and BDI values were higher in physically disabled mothers (p <0.05). WEEFIM total score higher in children with physical disabilities. The total WEEFIM score showed a positive correlation with the ODI score of the mothers. The total WEE-FIM score and the mothersnhp score showed a positive moderate correlation. in conclusion, in our study, the increased workload and excessive physical stress in mothers with a handicapped child caused an increase in back pain and the pain was found to affect the daily life of mothers of mothers.the quality of life of mothers.increased physical loading and the mood of giving care to disabled children negatively affect the quality of life of mothers.Increased physical loading and the mood of giving care to disabled children negatively affect the quality of life of mothers.Publication Open Access Farklı estetik abutmentların döngüsel yorulma yüklemesi sonrasında kırılma dayanımlarının değerlendirilmesi(Bezmialem Vakıf University, 2015) Balcı, Berna; Üşümez, AslıhanThe aim of this study was to compare the fracture strength of peek abutments and zirconium abutments which are widely preferred instead of titanium abutments in the esthetic zone for the implant supported fixed prosthesis. In this study, the fracture strength of zirconium and peek abutments were compared after aging by chewing simulator. Study groups were; Group 1: 10 zirconium abutments on the implants (Bredent, Germany, 12 mm length and 4 mm diameter) , Group 2: Peek abutments on the implants (Bredent, Germany, 12 mm length and 4 mm diameter). All implants are embeded into an acrylic resin (Paladent-Kulzer) with 45° angle and torqued with 25 N to the implants. Afterwards, zirconia cores (Zenostar T2 Wieland) were cemented with temporary implant cement (Premier; ABD). Fatique test was performed with a chewing simulator for 1,2 million cycles. Subsequently, load to fracture test was applied by a loading device (Shimadzu, Japan) to all specimens with a speed of 1mm/ min. The fracture strength values were 478,83± 66,72 N for peek abutment group and 722,50± 84,71 N for zirconium abutment group. The results were statistically analysed with T-test. The fracture strength of zirconia abutments were statistically significantly higher than peek abutments (p< 0,001). Key words: Zirconia, ceramic, peek, abutment, fracture strengthPublication Open Access Farklı marka implant frezleri ile yapılan osteotomilerde kemikte meydana gelen sıcaklık değişimlerinin in-vitro olarak incelenmesi(Bezmialem Vakıf University, 2016) Şarkbay, Ömer Faruk; Mihmanlı, AhmetThe aim of this thesis was to investigate in vitro temperature changes during drilling in the bone by using implant drills which are produced by different companies. In this study, bone specimens obtained from fresh beef ribs were used. Drilling has been performed on the bone specimens by using the Ankylos, Astra Tech, Nobel Biocare, Bredent Straumann implant systems with 2 kilograms static downward force and 30±2 0C ambient temperature. Two K type thermocouples were placed in the 5 and 10 mm depth of bone specimens and temperature was measured at the distance of 1 mm from the implant drills. In our study, different experimental models were prepared to make implant site preparation. The experiment was based on four groups: in Group 1, drills were used for the first osteotomy at the speed of 150 rpm without irrigation; in Group 2 drills were used for the first osteotomy at the speed of 1200 rpm with irrigation (40 mL/min); in Group 3 drills were used for up to 30'th osteotomies at the speed of 150 rpm without irrigation and in Group 4 drills were used for up to 30'th osteotomies at the speed of 1200 rpm with irrigation (40 mL/min). Whole osteotomies were performed in eight minutes with 3.5±0.3 mm diameter drills and temperature values obtained in the eight equal time periods were recorded. Statistical analysis of the values was performed by using Repeated Measures and Kruskall Wallis tests. No significant difference was observed in each group for different implant brands according to temperature changes while drilling of the bone specimens (p<0.05). The critical temperature (47C+) was not recorded in any of the experimental models. In the 5 and 10 mm depth, the temperature change levels were similar to each other. Therefore, although the mean temperature values were similar in the irrigation and non-irrigation systems, the values obtained by subtraction of initial temperatures were significantly higher in non-irrigation groups. The results of this study showed that different implant drills (produced by Ankylos, Astra Tech, Nobel Biocare, Bredent, Straumann companies) and repeated drilling do not cause significant temperature rise during the osteotomy in bone specimens. Otherwise, we concluded that both irrigation and non-irrigation systems are safe in reasonable working conditions.Publication Open Access Ferulago blancheana bitkisindeki sekonder metabolitlerin izolasyonu, antioksidan ve antikolinesteraz aktivitelerinin incelenmesi(Bezmialem Vakıf University, 2016) Aslan, Esin; Topçu, GülaçtıThe Ferulago is an aromatic (fragrant) plant, which is a member of one of the flowering plant families, the Apiaceae (=Umbelliferae). The Ferulago and its similar species are known as the "giant fennel" (Çakşır, Çağşır); it is used by people traditionally to soothe the nervous system, relieve gas, get rid of worms, and its roots are separately used as an aphrodisiac. The Ferulago blancheana Post which is currently being worked on, is an endemic species that grows in Kahramanmaraş Başkonuş (Square C6). The Ferulago blancheana was first introduced to the scientific world in Boisser's work "Flora Orientalis Supplementum" which was published in 1888. Until today, in Turkey and the world, the Ferulago species have mostly been worked for their volatile oils and some activities, in general. The Ferulago species, as well as having very little work done in terms of its isolation and other metabolites, the Ferulago blancheana is being worked on for the first time in terms of its volatile oil, isolation, and the use of secondary metabolites. In this thesis study, eight compounds have been isolated from Ferulago blancheana plant. In the first stage, the Ferulago blancheana plant's dichloromethane and ethyl acetate /methanol extracts were prepared. After the total phenolics amount and the total flavanoids amount were accounted to as equal to quercetin, and antioxidant activities were detected by inhibition of lipid peroxidation and DPPH free radical scavenging methods. Dichloromethane and ethyl acetate/methanol extracts of Ferulago blancheana and the anticholinesterase activities of the pure compounds isolated were identified using the Ellman method against the AChE and BChE enzymes. As the main secondary metabolites of the exracts coumarins, and five furanocoumarin, and two steroids structure isolated and purified; their structures were identified using spectroscopic (NMR, UV) methods. Keywords: Ferulago blancheana; furanocoumarin; antioxidant activity; anticholinesterase activity; heraclenol; imperatorin This research was supported by the Scientific Research Unit of Bezmialem Vakıf University. Project No: 9.2014/17Publication Open Access Format dehidrogenaz enziminin candida boidinii'den moleküler olarak klonlanması, ekspresyonu ve karakterizasyonu(Bezmialem Vakıf University, 2017) Arlı, Nazlı; Akbaş, FahriEnzyme production has an important place in modern biotechnological industry. Factors as expensiveness of enzyme extraction from plantal and animal sources, difficulty of getting standardization in terms of quality and quantity have increased the tendency toward microbial sources. With the development of recombinant DNA technology and its manipulability on microorganisms, the global industrial market for recombinant enzymes was indicated at 4.61 billion dollars in 2016. This market is expected to reach 6.3 billion dollars by 2022 in terms of value, at a compound annual growth rate of 5.8% from 2017. NAD+-dependent formate dehydrogenase (FDH, EC 1.2.1.2) is an enzyme that catalyzes the oxidation of formate ions to CO2 concurrently reduction of NAD+ molecule to NADH. Expensive cofactors like NAD(H) and NADP(H) are needed in reactions where enzymatic reduction is important. Cofactor regeneration methods have been developed on the purpose of offering affordable alternatives. In these methods, FDH is one of the most preferred enzymes thanks to its advantageous properties. No by-product accumulation, inertness to the reaction substrate, suitable thermodynamic equilibrium, wide pH range features raise FDH enzyme into a privileged position. Synthetic production of this enzyme has gained importance in recent years since it is frequently used for the production of optically active compounds in pharmaceutical industry and diagnostic tests in clinical biochemistry laboratories. Studies showed that FDH enzyme can be produced recombinantly from various methylotrophic bacteria and yeasts. In this study, cloning of the gene encoding FDH enzyme from Candida boidinii (C. boidinii) ATCC 18810 yeast strain into Escherichia coli (E. coli) bacterium, expression and characterization of the gene product, FDH enzyme, was aimed. In line with this purpose, first, genomic DNA of C. boidinii was isolated, target gene was amplified with polymerase chain reaction (PCR) and the expected 1104 bp band was seen. Amplified gene was cloned into pTZR57R/T vector via TA cloning method and E. coli One Shot® Mach1™-T1R cells were transformed with the recombinant vector pTZR57R/T+FDH. The vector within the transformed cells was digested with NdeI and BamHI restriction enzymes and the target FDH gene transferred to pET-14b expression vector that was treated with the same restriction nucleases. E. coli One Shot® Mach1™-T1R cells were transformed with the new recombinant vector, pET-14b/FDH. Transformation success was verified with colony PCR, restriction enzyme digestion and sequence analysis. Afterwards, pET-14b/FDH vector was transferred to E. coli One Shot® BL21 (DE3) expression cells. FDH enzyme production was induced with IPTG and produced protein was purified with Ni-NTA affinity column chromatography. SDS-PAGE and Western blot analyzes were carried out to see the presence of FDH protein and both of them displayed expected 41 kDa bands. Finally, enzyme assays were done to determine ideal activity conditions. Results were evaluated by 340 nm wavelength absorbances of enzymatic reaction product, NADH. In consequence of characterization studies, it was determined that recombinant FDH enzyme works efficiently at pH 8.0 Tris buffer solution with 40 mM formate substrate concentration until the temperature reaches 60°C. This enzyme which is frequently used in pharmaceutical industry and clinical biochemistry laboratories is provided from foreign sources in our country thereby it becomes costly. This study is important in the way of providing data for national production of FDH enzyme and starting large scale production in industrial area.