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Publication Open Access 6-paradol molekülünün amiloid beta enjeksiyonu ile oluşturulmuş alzheimer hastalığı modelindeki nöroinflamatuvar ve nöroprotektif etkilerinin araştırılmasıKİNSİZ, Beyza; ELİBOL, BirsenAlzheimer's disease (AD) is a progressive type of age related dementia in humans. It is considered that increase in oxidative stress due to microglia activation may cause progression of the disease. Studies have shown that 6-Paradol, one of the ginger metabolites, has positive effects on memory and reduces microglia activated-neuroinflammation. Therefore, the aim of the present study is to investigate the neuroprotective and anti-neuroinflammatory effects of 6-Paradol in amyloid beta (Aβ1-42)-injected AD model in rats. In this study, 33 adult rats (12-month-old) were divided into 5 groups; healthy control (n=6, no treatment), Sham control (n=6, Aβ1-42 solvent (5 µL) injected by intracerebral injection (i.c.v)), Aβ1-42 (n=9, 5 µL Aβ1-42 (i.c.v.) to the hippocampus), Positive control (n=6, 5 µL Aβ1-42 (i.c.v.) and 21 days of donepezil (2mg/kg) treatment), 6-Paradol (n=6, 5 µL Aβ1-42 (i.c.v.) and 2 weeks of 6-Paradol (5 mg/kg) treatment). Behavioral tests were performed after two weeks of treatment. Then, the rats were sacrificed and histological and molecular studies were performed. As a result, compared to the control group, it was observed that the rats in the Aβ1-42-injected AD group had delay in learning and deficiency in memory performance which measured by Morris Water Maze and passive avoidance test. 6-Paradol had no effect on learning and memory performance of rats. According to the resuls obtained by hematoxylin and eosin, the histological structures of brain tissues of the control groups and pozitive drug group were similar each other which were healthy appearance. However, in sections belonging to Aβ1-42 and 6-Paradol groups, it was observed that the nuclei of some neuronal cells were irregular and pycnotic. Also, there was vacuolization in brain tissue of the 6-Paradol group. According to Nissl staining, there was a significant decrease in the number of CA1 pyrimidal cells in the Aβ1-42 group of hippocampus (p<0.05). An increase in cell count was observed in the treatment groups given Donepezil and 6-Paradol. In Congo-red staining, which shows the presence of amyloid plaques, there was no change in the groups with treatment. Protein expression studies performed with Western blotting showed that apoptosis increased in the Aβ1-42 group and decreased significantly in the treatment groups. Also the expressions of fractalkine and fractalkine receptors, which are associated with microglia activation, were examined, and there was no significant change in the amount of fractalkine ligand among groups, there was a significant increase in its receptor in the Aβ1-42 group and this increase was improved by 6-Paradol treatment. While the amount of AD indicator proteins (pTau and PSEN1) increased with Aβ1-42, the concentrations of these proteins decreased to control levels by 6-Paradol treatment. No significant difference was observed among groups in the expression of BACE and Reelin proteins. In summary, the 6-Paradol teratment in AD model of rats shows an anti-inflammatory effect as it causes an improvement in microglia-related proteins.Publication Open Access Acil servise ateşli silah yaralanması ile başvuran hastaların analiziAKBALIK, Saadet; TAŞLIDERE, BahadırPurpose and Hypothesis: To investigate the conditions that have an impact on the mortality of patients admitted to the emergency department due to high kinetic energy gunshot wounds. For this purpose; The aim of this study is to compare the demographic structure of the patients, injury site, surgical indications, laboratory values and trauma scores, and to discuss their differences with studies conducted in our country and around the world, and their reasons. Method: Our study was carried out between 01 January 2016 and 31 December 2016. The patients were divided into two groups as living and deceased. Age, gender, occurrence of the event, vital signs, injury site, involving more than one anatomical area, surgical treatment requirement, whether fracture surgery was performed, chest tube insertion status, laboratory parameters were compared. ISS, RTS and TRISS scores were compared between groups with living and deceased patients. Cut of values were calculated by performing ROC analysis. How useful they are in estimating mortality was investigated. The research data were recorded in IBM SPSS Statistics for Windows, version 21.0 and statistical analysis was performed. Finding: 127 patients over the age of 18 who applied to the emergency department due to high kinetic energy gun injury and were brought directly from the area were included. The patients were divided into two groups as living and deceased. When the laboratory findings of the patients were examined; Considering the trauma scores, it was seen that the ISS averages of the living individuals were lower than the deceased individuals, and the average of the RTS and TRISS scores of the surviving individuals was higher than the deceased individuals. The mean Systolic Blood Pressure of the living individuals is lower compared to the deceased individuals, the Respiratory Number of the deceased individuals is higher than the living individuals, and the GCS averages of the deceased individuals are significantly lower than the living individuals. Conclusion: In patients brought to the emergency room with individual gunshot wounds, vital signs and laboratory tests should be evaluated quickly and trauma scores with proven effectiveness such as ISS, RTS and TRISS should be calculated. These trauma scores differed between deceased and surviving patients. It should be known that mortality is high in gunshot wounds with head, neck and spinal injuries. In addition, patients with vascular injuries should be given priority. In cases of firearm injury, it is the most accurate method to make a decision with evidence-based findings obtained by utilizing the way the event occurred, the site of injury, vital signs, laboratory values and trauma scores.Publication Open Access Açık ya da kapalı büyük ameliyatların cerrahi dumanı hastanın karbonsihemoglobin, methemoglobin ve bazı kan gazlarını olumsuz etkiler mi?(2020-02) BİÇER, Elif; SAYIN, YazileSurgical smoke appears in the majority of closed or open surgeries.Carcinogens in the smoke cause non-negligible risks. The aim of this study is to investigate the effect of the surgical smoke caused by the surgical instruments on levels of patients` blood gas, carboxyhemoglobin, and methemoglobin. The descriptive study was carried out in Gaziosmanpaşa Taksim Training and Research Hospital between April 2019 and October 2019 after the approval of the ethics committee and institution. The study was conducted in 87 volunteer patients who were scheduled for open and closed surgery. The data was collected with laboratory reports and 'the Patient Identification Information Form' which contained 20 questions. The normality distribution of the data was analyzed in IBM SPSS 22.0 program and proper comparison tests were selected. Differences were considered statistically significant at p < 0.05 level. The mean age of the participants was 56.45 ± 16.30 and the body mass index was 25.22 ± 3.24. 57.5% (n = 50) of the participants were smokers, 63.2% (n = 55) did not have any chronic diseases, 21.8% (n = 19) had cardiovascular diseases, 15% (n = 13) had a metabolic disease. There was the only airflow in all rooms where the participants underwent surgery. The mean duration of surgery was 3.78 ± 1.59 hours. In open surgical procedures (n = 56), the effects of surgical smoke on blood gas were less (p <0.05) than laparoscopic surgical procedures (n= 31). In terms of surgical smoke production, monopolar (71.3%) and bipolar (48.3%) inserts of electrocautery were more than laser and ultrasound scissors (p <0.05). The method used to remove surgical smoke was a 46% aspiration probe. Aspiration probes indicated positive effects on blood gases and carboxyhemoglobin (p <0.05). It was found that the mean bleeding of patients was 412,18±530,44 cc during operations. It was observed that significant changes in arterial PaCO2, PaO2, MetHb, COHb, pH levels compared to preoperative values (p=0.035; p=0.001; p=0.052; p=0.640; p=0.034). In the present study, surgical cutters used in the majority of patients had surgical smoke production. Postoperative arterial PaCO2, PaO2, MetHb, COHb, changes in pH values compared to preoperative values of the patients indicate that there is not an effective ventilation system and a successful technique to remove smoke from tissues. In this study, surgical instruments used in the majority of patients cause surgical smoke production. Postoperative changes in arterial PaCO2, PaO2, MetHb, COHb and pH levels compared to the preoperative levels of the patients indicate that there is no effective ventilation system and a successful technique to remove smoke from the tissues.Publication Open Access Adheziv kapsülitli hastalarda ağrının fonksiyonellik, kinezyofobi, uyku kalitesi ve yaşam kalitesine etkisi(Bezmialem Vakıf University, 2017) Bilge, Ceren; Özyılmaz, Semiramis50 patients who had adhesive capsulitis diagnosed and shoulder pain complained were included in our study to investigate the relationship between pain, functionality, kinesiophobia, quality of sleep and quality of life. Visual Analog Scale (VAS) was used to determine the pain level, The Disabilities of the Arm, Shoulder and Hand (DASH) was used to assess functionality, Tampa Scale of Kinesiophobia (TSK) was used to determine the kinesiophobia level, Pittsburgh Sleep Quality Index (PSQI) was used assess the sleep quality and quality of life was assessed by the Nottingham Health Profile (NHP). There was a significant correlation between pain severity and TSK, DASH total score, some sub-parameters of PSQI and NHP (p<0,05). There was a significant correlation between DASH score and some sub-parameters of PSQI scores (p<0,05). Also, there was a significant correlation between DASH score and all quality of life sub-parameters except NHP sleep (p>0,05). There was a significant correlation between TSK score and all sub-parameters of NHP except NHP pain and some sub-parameters of PSQI (p<0,05). Also, there was a significant correlation between PSQI and some sub-parameters of NHP (p<0,05). As a result, this study showed that the common symptom of pain in adhesive capsulitis patients had a negative effect on functionality, kinesiophobia, quality of sleep and quality of life.Publication Open Access Adli bilim uzmanları ve teknikerlerinin küresel pandemi yönetim stratejileri hakkındaki görüşlerinin SARS-CoV2 pandemisi üzerinden değerlendirilmesiULUTAŞ, Mehmet; ESEN MELEZ, İpekThe SARS-CoV2 pandemic has entered our lives as a pandemic that threatens the lives of millions of people. This study was implemented to assess the opinions of forensic science experts and technicians of The Ministry of Justice Council of Forensic Medicine on global pandemic management strategies including new technologies and future scenarios through SARS-Cov2 pandemic. In addition, this study was a prospective, descriptive research and was carried out with a questionnaire that was asked to 244 personnel (forensic medicine specialist, forensic medicine resident, technician, other specialist from a different field, other specialist phsician) working at The Ministry of Justice Council of Forensic Medicine. The 40-question survey included questions about participants' level of knowledge perception about the pandemic and attitudes on measures-their adequacy-necessity, technological applications and the future of global management strategies. 24.2% (n=59) of the participants were forensic medicine specialists, 29.5% (n=72) were forensic medicine residents, 18.9% (n=46) were technicians, 17.2% (n=42) were other specialist phsicians and 10.2% (n=25) were other specialists/engineers. 93.8% (n=229) of the participants thought they had knowledge about the pandemic and its transmission routes, 54.1% (n=132) found the applied pandemic management strategies effective and correct, and 76.6% (n =187) stated that it is necessary to use technological infrastructures in future scenarios. As a result, through hundreds of descriptive statictics results in 80 tables classified according to education level, occupation type and occupational experience level, in general, despite the changes in group tendencies according to different factors, the majority of participants were found to be obeying the routine necessities of the pandemic, hesitating on the global strategies, feeling closer to habitual technologies, feeling far to technologies which have never experienced before in daily life, giving answers with a high ratio of "no opinion" due to feeling obliged to give decisions gropely among unproven propabibilities or due to their hesitation on sharing their opinion even if they had an opinion. Moreover according to results, it was interpreted that social engineering could easily be performed in any spesifically designed group in the world.Publication Open Access Adli bilim uzmanları ve teknikerlerinin SARS-CoV2 pandemisi hakkındaki bilgi ve anksiyete düzeylerinin değerlendirilmesiARSLAN, Mustafa; ESEN MELEK, İpekBu araştırma T.C. Adalet Bakanlığı Adli Tıp Kurumu Başkanlığında çalışan adli bilim uzman ve teknikerlerin Severe Acute Respiratory Syndrome – Corona Virus2 (SARS-CoV2) Pandemisi bilgi ve anksiyete düzeylerinin değerlendirilmesi amacıyla prospektif, tanımlayıcı ve kesitsel olarak gerçekleştirildi. Araştırma verileri 01/10/2020 – 30/11/2020 tarihleri arasında İstanbul'da Adli Tıp Kurumu Başkanlığı içerisinde çalışan 295 kişi üzerinde uygulanan kişisel bilgiler, Koronavirüs 19 Fobisi (C19P – S) ölçeği, literatür doğrultusunda oluşturulan bilgi düzeyi sorularını içeren bir anket formu ile toplanarak elde edildi. Kaydedilen yanıtlara göre oluşan değerler, IBM SPSS 20.0 (IBM Corp.,Armonk,NY,USA) programı kullanılarak analizleri yapıldı. Veri analizlerinde, tanımlayıcı istatistik uygulamaların yanı sıra, verilerin normal dağılıma uygun olup olmadığını kontrol için Kolmogorov-Smirnov ve Shapiro-Wilk testleri ve karşılaştırma analizlerinde Spearman's korelasyon katsayısı, T testi, Mann Whitney U testi ve Kruskall-Wallis testi uygulandı. Anlamlılık düzeyi p<0,05 olarak kabul edildi. Araştırmaya katılan adli bilim uzmanları ve teknikerlerinin %56,3'ünün erkek, %43,7'sinin kadın olduğu, %60'ının lisansüstü, %20,3'ünün lisans, %19,7'sinin ise önlisans mezunu olduğu, %24,4'ünün 18-27 yaş, %51,2'sinin 28-37 yaş, %13,6'sının 38-47 yaş, %8,1'inin 48-57 yaş aralığında, %2,7'sinin ise 58 yaş üzeri olduğu, %67,8'sinin ihtisas dairelerinde, %32,2'sinin ise ihtisas kurullarında görev yaptığı, %17,3'ünün adli tıp uzmanı, %26,8'inin adli tıp uzmanlık öğrencisi, %8,1'inin diğer uzman doktor, %10,8'inin diğer uzman / görevli, %12,2'sinin mühendis, %24,7'sinin tekniker olduğu tespit edildi. Katılımcılara bilgi değerlendirmesi amacıyla yöneltilen sorulara verilen cevaplarda cinsiyete, çalıştığı birime göre anlamlı bir ilişki ve fark bulunamadı. Eğitim durumuna göre bilgi değerlendirmesinde lisans mezunu(16,57±7,51) katılımcıların bilgi toplam puanları önlisans(23,74±6,52) ve lisansüstü(23,29±6,63) gruplardan düşük olarak bulundu. Meslek grubuna göre bilgi değerlendirmesi toplam puanı en düşük olan grubun mühendis(12,00±4,95) katılımcılarda olduğu tespit edildi. Sağlık ile direkt ilişkili olan adli tıp uzmanı(24,78±5,98), adli tıp uzmanlık öğrencisi(24,78±5,53) ve teknikerlerin(23,84±6,61) bilgi toplam puanında diğer meslek gruplarından daha yüksek puan aldığı bulundu. Katılımcıların psikolojik alt boyut puan ortalaması 18,69±5,73, psikosomatik alt boyut puan ortalaması 8,93±3,72, sosyal alt boyut puan ortalaması 14,65±4,47, ekonomik alt boyut puan ortalaması ise 8,54±3,39 olarak bulundu. C19P – S ölçeği toplam puan ortalaması 50,80±14,56 olarak bulundu. Kadın katılımcıların psikolojik ve toplam C19P – S ölçek puanları erkeklere göre daha yüksek, ihtisas dairelerinde çalışan katılımcıların C19P – S toplam puanı ihtisas kurulunda çalışan katılımcılardan yüksek bulundu. En yüksek C19P – S ölçeği toplam puanı tekniker olarak görev yapan katılımcılarda tespit edildi. Katılımcıların eğitim durumuna göre C19P – S toplam puanı karşılaştırmasında istatiksel anlamlı fark bulunamadı. Çalışmada adli bilim uzman ve teknikerlerinin bilgi ve anksiyete düzeyleri "orta" olarak saptandı. Bu çalışmanın bulguları adli bilim çalışanlarının salgın sürecinde yüksek bulaş riskiyle çalışmanın getirdiği stresin yanında, enfeksiyon kontrol önlemleri kapsamında ertelenen uygulamalar, dolayısıyla birikebilen iş yükü vb. nedenler ile psikolojik olarak etkilenebildiğini, ancak başa çıkma oranlarının da stres düzeyini "orta" seviyesinde tutmaya yetecek güçte olduğunu; bilgi puanlarının da orta düzeyde bulunmasının bireylerin SARS – CoV2 özelinde daha fazla sağlık okuması ve araştırması yapması gerekliliğini ortaya koyabileceği gibi, SARS – CoV2 süreçleri ile ilgili belirgin bilgi kirliliği de bilgi puanları üzerinde etkin olabilir şeklinde yorumlanmıştır.Publication Open Access Adölesan İdiyopatik Skolyozlu Çocuklarda Core Stabilizasyon Eğitiminin Solunum Parametreleri, Periferik Kas Gücü, Denge, Fonksiyonel Kapasite ve Yaşam Kalitesi Üzerine Etkisi(Bezmialem Vakıf University, 2019) Yıldırım, Sefa; Özyılmaz, SemiramisThe three-dimensional deformity of the vertebrae with lateral flexion in the frontal plane of 10 ° and in the axial plane and the flattening components in the physiological curve in the sagittal plane is defined as scoliosis. 80% of the structural scoliosis is idiopathic scoliosis. Adolescent idiopathic scoliosis (AIS) is a variant of idiopathic scoliosis occurring from the onset of puberty (above 10 years of age) until the growth plates are closed. Conservative and surgical treatment options have been reported in the treatment of AIS. Conservative treatment includes observation, exercise and orthotic options. The primary purpose of conservative treatment in AIS is to correct secondary damage including back pain, respiratory problems, balance problems and cosmetic deformations by preventing progression of the curve and improving quality of life. Specific exercise methods are used in conservative treatment. Core Stabilization exercises are also one of these methods. The aim of this study was to investigate the effects of Core Stabilization training on respiratory parameters, peripheral muscle strength, balance, functional capacity and quality of life in AIS patients. The study included 30 children aged 10-20 years with AIS who were randomly assigned to experimental and control groups. Pulmonary function test (PFT), respiratory and peripheral muscle strength measurement, 6 min walk test (6 MWT) and Biodex Balance System® device and postural stability and stability limits were applied to all patients. Exercises given to the experimental and control groups were administered under the supervision of a physiotherapist for 1 week, in the home 6 days a week for 8 weeks. Traditional scoliosis exercises were given to the control group. In addition to the traditional scoliosis exercises, the core exercise program was included for training group. At the end of eight weeks, evaluations were repeated. SPSS Statistics 21.0 program was used for data analysis. The significance level was accepted as p <0.05 for all analyzes. At the end of the 8th week, in the training group, trunk rotation angle, forward and side tilt angles, respiratory function test parameters % FVC and% FEV1 values, respiratory muscle strength values (MIP, MEP), some parameters in the stability test stability parameters, hand grip and quadriceps muscle strength, functional capacity, cosmetic deformity perception score and some parameters of quality of life. In the control group, statistically significant improvement was found in forward and side bending angles, MIP values, stability parameters in stability test, quadriceps muscle strength, functional capacity and some sub-parameters of quality of life. When the training and control groups were compared, some improvement was observed in the education group in some respiratory parameters and in the perception of cosmetic deformity. Considering the literature and the results of our study, it was concluded that Core Stabilization exercises could be applied to AIS patients and added to routine physiotherapy program. keywords: adolescent idiopathic scoliosis, core stabilization exercises, pulmonary function test, respiratory muscle strength, peripheral muscle strength, cosmetic deformity perception, quality of lifePublication Open Access Adolesanlarda sağlık okuryazarlığı ile sağlıklı yaşam biçimi davranışları arasındaki ilişkinin belirlenmesiKARAGÖZOĞLU, Merve; İLHAN, NeslihanThis study was conducted as a correlational study to determine the relationship between health literacy and health behaviors in adolescents. The study was carried out with 649 students in four high schools on the Anatolian side of Istanbul between December 2019 and March 2020. The socio-demographic characteristics questionnaire, the Adolescent Lifestyle Profile II (ALP-R2) and the Health Literacy Scale for School Age Children were used to collect the data. Descriptive statistical methods (mean, standard deviation, frequency), Student's t-test, one-way analysis of variance (ANOVA) test, and Pearson's correlation analysis were used to evaluate the data. The mean age of the adolescents who participated in the study was 15.54±0.95, 59.8% of them were girls, and 41.1% of them were 11th-grade students. It was determined that while 65% of adolescents had BMI within normal limits, 48.7% of them considered their health as good, and 85.4% of them had not heard of the concept of health literacy previously. It was determined that the mean score of the health literacy scale of the students who participated in the study was 28.95±5.79, and 61.9% of them had a moderate level of health literacy. The mean total score of the ALP-R2 scale was found to be 114.35±17.48. It was determined that females' mean score of the health responsibility and interpersonal relations sub-dimension was higher compared to males and that males' mean score of the nutrition and physical activity sub-dimension was higher compared to females. The mean score of the stress management sub-dimension of the 9th-grade students was higher compared to the 11th-grade students, the mean score of the spiritual health sub-dimension of the 11th-grade students was higher compared to the 10th-grade students, and the mean total score of the ALP-R2 scale of the 9th-grade students was higher compared to the 10th-grade students. The mean score of stress management of adolescents whose mothers were primary school graduates was found to be higher compared to the adolescents whose mothers were illiterate and literate. The mean total score of nutrition, stress management and the ALP-R2 scale of those with a broken family was found to be lower compared to the adolescents with a nuclear family and extended family. The mean score of health responsibility, positive perception of life, interpersonal relations, stress management and the ALP-R2 scale of the adolescents who spent the longest part of their life in cities and districts was found to be higher compared to those who spent the longest part of their life in the village. The mean score of all sub-dimensions of the ALP-R2 scale and mean total scores of the adolescents who participated in social activities were found to be higher compared to the students who did not participate in social activities. The mean score of the health responsibility sub-dimension of those with a disease that is constantly treated and those with medication was high. However, their mean score of the physical activity sub-dimension was found to be low. The mean score of the health responsibility sub-dimension of the adolescents who considered their health status as very good was found to be high compared to those who considered their health status as poor and moderate. The mean score of the positive perception of life sub-dimension of obese adolescents was found to be lower compared to those who were underweight, normal weight, and overweight. While the mean score of all sub-dimensions of the ALP-R2 scale and mean total scores of those with a high level of health literacy were found to be higher compared to those with a moderate and low level of health literacy, the mean score of all sub-dimensions of the ALP-R2 scale and mean total scores of those with a moderate level of health literacy were found to be higher compared to those with a low level of health literacy. A positive and significant relationship was found between health literacy score and the ALP-R2 scale. As a result of the study, it was determined that as the health literacy level of adolescents increased, their health behaviors increased positively.Publication Open Access AFAD İstanbul arama kurtarma birliği çalışanlarının ekip çalışmasına yatkınlığıÖZKAR, Yalım; ERDOĞAN, ÖzcanThis research was conducted descriptively and cross-sectionally in order to determine the relationship between AFAD Istanbul Search and Rescue Association employees and teamwork tendency. The research was carried out with 67 employees working in Search and Rescue Association of Disaster and Emergency Directorate in Istanbul between 02.11.2018- 01.01.2019. Data were collected by using the Descriptive Information Form and the Teamwork Tendency Scale. Descriptive statistics were used to evaluate the data. The average age of the participants was 39.58 ± 5.81 and 89.6% were male. 23.9% of them have associate degree and 70.1% of them have bachelor degree. 77.6% are married. 52.2% have been working in the current institution for more than 15 years. 53.7% of the total working time is over 15 years. 19.4% are graduates from agriculture department. 58.2% are employed as search and rescue technicians. 29.9% of the employees evaluated their own teamwork as very good and 31.3% as good. 53.7% said they had a problem with teamwork. The average point of the trust subscale of those aged 40 and under, was significantly determined higher than those over 40 years of age (p:0,020; p<0,05). Average point of sub-dimension of diagnosing and analyzing the problem of high school / associate degree graduates was found to be statistically higher than bachelor's and above graduates (p:0,039; p<0,05). High internal motivation subscale average point of high school / associate degree graduates were found to be statistically higher than those of bachelor's and above graduates (p:0,024; p<0,05). The average point of responsibility subdimension of those who think that teamwork is very good was found to be significantly higher than those who think that it is medium and lower (p:0,015; p<0,05). The average point of cooperation and teamwork sub-dimension of those who think that teamwork is very good, was found to be significantly higher than those who think that teamwork is moderate and under (p: 0.001) and good (p: 0.020). (p<0,05; p<0,01). High internal motivation subscale point of those who think that teamwork is very good, was found to be significantly higher than those who thought that the teamwork was moderate and below (p: 0.019) and good (p: 0.029). (p<0,05). The average point of leadership, persuasion, perseverance sub-dimension of those who think that teamwork is very good, was found to be significantly higher than those who thought that teamwork was was moderate and below (p: 0.001) and good (p: 0.01). (p<0,01). The average point of cooperation and teamwork subscale scores of those who encountered problems during the teamwork was found to be significantly higher than those who did not encounter the problem (p:0,017; p<0,05). It was found that the employees evaluated the status of being a team member as good but encountered problems during the team working. xiv In this study, it is concluded that teamwork is vital for the measures to be taken in case of disasters and emergencies and for interventions to be made at the event.Publication Open Access AFAD istanbul arama kurtarma birliği çalışanlarının örgütsel bağlılığıDEMİRBAŞ, Elif; ERDOĞAN, ÖzcanThe AFAD search and Rescue Association is based on volunteering and dedication in terms of working conditions. The human factor has an important place in the success of this institution. AFAD employees, who have a sense of commitment to their institutions, take great responsibility in providing superior services to organizations. It was also thought that the satisfaction of the employees, their commitment to their organization and the support of the organization will increase the quality and efficiency of the service the organization aims to provide. This research was carried out on a descriptive and cross-sectional basis in order to determine the relationship between AFAD Istanbul search and Rescue union employees and organizational commitment and to take necessary measures against the problems present in the institution. The research was carried out with 71 employees working in search and rescue unit of Disaster and Emergency Directorate in Istanbul between 02.11.2018 - 01.01.2019. Data were collected using Descriptive Information Form and Organizational Commitment Scale. Descriptive statistics were used to evaluate the data. The average age of the participants was 38.89 ± 6.32 years and 91.5% were male. 23.9% of them have associate degree and 67.6% of them have bachelor's degree. 81.7% are married. 50.7% have been working in the current institution for less than 10 years. Total working time of 46.5% is less than 12 years. 14.1% graduated from agriculture. 63.3% are employed as search and rescue technicians. Employees considered their organizational commitment to be 25.4% very good and 22.5% good. 54.9% said they faced a problem related to organizational commitment. The average point of the Organizational Commitment Scale was determined 3.07 ± 0.20. The average point of Organizational Commitment Scale of those whose total working period is 12 years or more was found to be statistically higher than those with a total working time of under 12 years (p:0,048; p<0,05). The average point of Organizational Commitment Scale of those who did not encounter a problem about organizational commitment was found to be statistically higher than those who encounter a problem about organizational commitment (p:0,015; p<0,05). It wasn't determined statistically significant difference between Organizational Commitment and age, gender, marital status, education level and working time in the current institution. It was found that the employees evaluated the status of having organizational commitment as good but faced with problems related to organizational commitment. At the same time, it was concluded that employees with a high level of organizational commitment can respond to the situation in a prepared and effective without stress manner in the event of a disaster.Publication Metadata only AFAD İstanbul Arama Kurtarma Birliğinin Ekip Çalışmasına Yatkınlığı(2019) Demirbaş, Elif; Erdoğan, ÖzcanThe AFAD search and Rescue Association is based on volunteering and dedication in terms of working conditions. The human factor has an important place in the success of this institution. AFAD employees, who have a sense of commitment to their institutions, take great responsibility in providing superior services to organizations. It was also thought that the satisfaction of the employees, their commitment to their organization and the support of the organization will increase the quality and efficiency of the service the organization aims to provide. This research was carried out on a descriptive and cross-sectional basis in order to determine the relationship between AFAD Istanbul search and Rescue union employees and organizational commitment and to take necessary measures against the problems present in the institution. The research was carried out with 71 employees working in search and rescue unit of Disaster and Emergency Directorate in Istanbul between 02.11.2018 - 01.01.2019. Data were collected using Descriptive Information Form and Organizational Commitment Scale. Descriptive statistics were used to evaluate the data. The average age of the participants was 38.89 ± 6.32 years and 91.5% were male. 23.9% of them have associate degree and 67.6% of them have bachelor's degree. 81.7% are married. 50.7% have been working in the current institution for less than 10 years. Total working time of 46.5% is less than 12 years. 14.1% graduated from agriculture. 63.3% are employed as search and rescue technicians. Employees considered their organizational commitment to be 25.4% very good and 22.5% good. 54.9% said they faced a problem related to organizational commitment. The average point of the Organizational Commitment Scale was determined 3.07 ± 0.20. The average point of Organizational Commitment Scale of those whose total working period is 12 years or more was found to be statistically higher than those with a total working time of under 12 years (p:0,048; p<0,05). The average point of Organizational Commitment Scale of those who did not encounter a problem about organizational commitment was found to be statistically higher than those who encounter a problem about organizational commitment (p:0,015; p<0,05). It wasn't determined statistically significant difference between Organizational Commitment and age, gender, marital status, education level and working time in the current institution. It was found that the employees evaluated the status of having organizational commitment as good but faced with problems related to organizational commitment. At the same time, it was concluded that employees with a high level of organizational commitment can respond to the situation in a prepared and effective without stress manner in the event of a disaster.Publication Metadata only AFAD İstanbul Arama Kurtarma Birliğinin Örgütsel Bağlılığı(2019) Özkar, Yalım; Erdoğan, ÖzcanThis research was conducted descriptively and cross-sectionally in order to determine the relationship between AFAD Istanbul Search and Rescue Association employees and teamwork tendency. The research was carried out with 67 employees working in Search and Rescue Association of Disaster and Emergency Directorate in Istanbul between 02.11.2018- 01.01.2019. Data were collected by using the Descriptive Information Form and the Teamwork Tendency Scale. Descriptive statistics were used to evaluate the data. The average age of the participants was 39.58 ± 5.81 and 89.6% were male. 23.9% of them have associate degree and 70.1% of them have bachelor degree. 77.6% are married. 52.2% have been working in the current institution for more than 15 years. 53.7% of the total working time is over 15 years. 19.4% are graduates from agriculture department. 58.2% are employed as search and rescue technicians. 29.9% of the employees evaluated their own teamwork as very good and 31.3% as good. 53.7% said they had a problem with teamwork. The average point of the trust subscale of those aged 40 and under, was significantly determined higher than those over 40 years of age (p:0,020; p<0,05). Average point of sub-dimension of diagnosing and analyzing the problem of high school / associate degree graduates was found to be statistically higher than bachelor's and above graduates (p:0,039; p<0,05). High internal motivation subscale average point of high school / associate degree graduates were found to be statistically higher than those of bachelor's and above graduates (p:0,024; p<0,05). The average point of responsibility subdimension of those who think that teamwork is very good was found to be significantly higher than those who think that it is medium and lower (p:0,015; p<0,05). The average point of cooperation and teamwork sub-dimension of those who think that teamwork is very good, was found to be significantly higher than those who think that teamwork is moderate and under (p: 0.001) and good (p: 0.020). (p<0,05; p<0,01). High internal motivation subscale point of those who think that teamwork is very good, was found to be significantly higher than those who thought that the teamwork was moderate and below (p: 0.019) and good (p: 0.029). (p<0,05). The average point of leadership, persuasion, perseverance sub-dimension of those who think that teamwork is very good, was found to be significantly higher than those who thought that teamwork was was moderate and below (p: 0.001) and good (p: 0.01). (p<0,01). The average point of cooperation and teamwork subscale scores of those who encountered problems during the teamwork was found to be significantly higher than those who did not encounter the problem (p:0,017; p<0,05). It was found that the employees evaluated the status of being a team member as good but encountered problems during the team working. xiv In this study, it is concluded that teamwork is vital for the measures to be taken in case of disasters and emergencies and for interventions to be made at the event.Publication Open Access Afet çalışanlarında psikolojik dayanıklılık ve stresle başa çıkma düzeyi(2020) ÇOBAN, Hafize; ERDOĞAN, ÖzcanThis research was carried out to examine the ways of disaster employees working in disasters to deal with psychological resilience and stress and to attract attention. For this purpose, medical and search and rescue teams working in Istanbul, which had to intervene in emergency and disaster situations that are dense in terms of population and region, were preferred. Descriptive and cross-sectional research was carried out with the Disaster and Emergency Management Directorate, 112 Provincial Ambulance Service, and National Medical Rescue Team employees working on the European side of Istanbul between February 2019 - May 2019. The data were collected in the light of expert opinions and literature, using the Introductory Information Form, Psychological Resilience Scale and Stress Coping Scale forms. In the analysis of the data obtained in this study IBM SPSS Statistics 22 (IBM SPSS, Turkey) programs were used. Significance value was taken as p <0.05. The correlation coefficient between Stress Coping variable and Psychological Resilience used in the study was calculated to be statistically significant at the significance level of 0.05, which was calculated as 0.584. A moderate relationship was detected between these two variables in the same direction. 228 people participated in the study carried out in two different institutions in Istanbul province and consists of 114 female and 114 male personnel. According to the demographic information, when looking at the psychological resilience levels, the ratio of 114 females was 81.11%, while 114 males were 81.63%. The marital status was found as 81.08%, with the single rate of 113, and the rate of 115 people with the rate of 81.66%. It was determined that it constitutes 82.64% and 28-36 years old personnel in the age variable. According to the educational level, the highest value was graduate staff with 84.12%. When we look at the gender variable with the levels of coping with stress, the ratio of 114 males was 89.29%, and the proportion of 114 females was 87.77%. Even though the rates are close, the level of male employees is high. According to the age variable, the highest value was found in personnel between the ages of 37-45 with a rate of 92%. In marital status, the proportion of 115 married people increased 90.20%, and there was no statistically significant value among singles. In educational situations, 51 people with a bachelor's degree were higher with 90.86%. According to the psychological resilience scale, disaster workers got the highest score from the challenge sub-dimension and the lowest score from the control sub-dimension. According to the stress coping scale, the most effective method consists of problem-oriented approaches. When the responses were evaluated, the problem solving dimension got the highest score, and it was found that the employees made individual behavioral interventions and the support seeking scores were low accordingly. This reveals the importance of social support. Although the level of psychological resilience and stress coping of disaster workers is high, group studies should be done in order to ensure that the staff socialize and see the social support of their environment.Publication Open Access Ağır Vasıta Sürücülerinde Ağrı, Postür, Uyku Kalitesi, Yorgunluk, Stres ve Yaşam Kalitesinin Değerlendirilmesi(2019) Yavuz, Yavuzhan; Özyılmaz, SemiramisIn our country, freight and passenger transport is largely used as a result, truck and bus drivers face an extreme workload. As a result of this intensive workload, drivers face a high risk of musculoskeletal problems, stress, fatigue and sleep quality. This study was carried out to investigate the differences between pain, postural changes, sleep quality, fatigue, stress and quality of life in urban and intercity heavy vehicle drivers. A total of 76 drivers 42 of them in cities including 17 (%40) of them are trucks, 25 (%60) of them are buses, 34 of them in intercities including 12 (%35) of them are trucks, 22 (%65) of them are buses participated in the study for at least 5 years, using 5-8 hours per day, without surgery and without spinal problems. The individuals pain assessments with McGill Melzack pain survey and visual analogue scale, postural changes by New York posture method, manual muscle tests and elasticity evaluations, hand grip forces with Baseline Smedley Digital Hand Dynamometer® device, sleep quality by Pitsburgh Sleep Quality Index, daytime sleepiness levels by Epworth sleepiness scale, fatigue severities by Fatigue Severity Scale, stress levels by Perceived Stress Scale and quality of life assestments by Nothingham Health Profile. SPSS v.20.0 program was used for data analysis. The results were considered significant with P-values<0,05. There was no statistically significant difference between the groups when the postural changes, pain complaints and pain severity of the drivers who used urban and urban heavy vehicles were compared (p>0,05). While our drivers had similar sleep quality, intercity drivers had higher daytime sleepiness compared to city drivers (p = 0,034). It was found that intercity drivers felt more severe than urban drivers (p <0,05). It was observed that the perceived stress level of urban drivers was higher (p <0,05) and this was related to cigarette consumption (p = 0,010) and food consumption (p = 0,015). When we look at the quality of life in urban and intercity drivers there is no difference but was found to be worse emotional reaction sub-parameter in city drivers (p <0.05) and to be worse to be worse energy sub-parameter in intercity (p = 0.004) drivers. As a result of our study, it was observed that both urban and intercity heavy vehicle drivers had similar problems with musculoskeletal system, the drivers who were driving by city were exposed to more stress, and the drivers who were by intercity felt more tired. Keywords; truck, bus, quality of life, pain, posture, sleep, fatigue, stressPublication Open Access Alzheimer modeli sıçanlarda kaempferol tedavisinin nöroprotektif ve iyileştirici etkisinin araştırılmasıUYSAL, Melike; ELİBOL, BirsenAlzheimer's disease is the most common type of dementia worldwide. There is no known cure for this neurodegenerative disease whose prevalence continues to increase every year. The main factors that form the pathology of Alzheimer's disease can be listed as senile plaques, neurofibrillary tangles and neuroinflammation. Oxidative stress is one of the main factors involved in the formation and progression of these pathologies. Many treatment initiatives aim to alleviate the neuropathogenesis of the disease and increase cognitive function. For this purpose, many herbal products and their active ingredients are used by researchers. Kaempferol is a flavonoid with anti-inflammatory and antioxidant properties produced as a secondary metabolite in many plants. Kaempferol's ability to reduce oxidative stress makes this molecule important in Alzheimer's disease studies. In this thesis study, firstly, streptozotocin (STZ) was injected intracerebroventricularly to Long-Evans male rats for modelling Alzheimer's disease. Kaempferol, an anti-neuroinflammatory agent, was administered intraperitoneally to the rats. At the end of the treatment, the neuroprotective effect of kaempferol was examined by conducting behavioral and molecular experiments. While kaempferol did not show a significant difference in the learning and memory test performed in the morris water maze, it made a significant difference between the groups in the passive avoidance test measuring fear-conditioned memory. However, while STZ injection did not show a significant change in PSEN level, it caused an increase in BACE and phosphorylated TAU levels. Interestingly, Kaempherol had no significant curative effect at the molecular level. These results show that kaempferol treatment has positive effects on memory loss which is one of the phenotypic features of Alzheimer's disease. For this reason, this study guides the future studies in terms of examining in detail the molecular bases of the healing effect of kaempherol in order to be a candidate molecule in the treatment of Alzheimer's disease.Publication Open Access Ameliyat sırası basınç yaralanması ve risk faktörlerinin belirlenmesiİPEK, Büşra; SAYIN, YazileThis study was planned to determine the risk of intraoperative pressure injury (IPJ) specific to the surgical site and the factors contributing to its occurrence. The research is a descriptive cross-sectionsl design. The study was carried out on 200 patients who underwent surgery in the operating rooms of a private university hospital. Data of the study were obtained through the patient clinical records of the "Sociodemographic and Clinical Characteristics Form" and the "3S Intraoperative Risk Assessment Scale of Pressure Sore, Turkish Form (3S-RTÖ)". Voluntary consent was obtained from the ethics committee, institutions, and participants for the study. 53.5% of the participants were female, average age was 50.26±17.30, and 40% had chronic diseases. Intraoperative pressure injury was seen only as Stage I in 18% of them. The 3S-RTÖ risk score of 36 (18.0%) patients who developed pressure injury (17,64±3,081) was evaluated as higher risk than the 3S-RTÖ risk score of 164 (82.0%) patients who did not develop pressure injury (p=0,004). Intraoperative pressure injury; was more common in female (p=0.013) patients, those over the average age of 57 years (p=0.004), and those with chronic diseases (p=0.035), and with blood pressure changes (hypo/hypertension). The fact that the amount of bleeding of the participants was more than 200 ml, the duration of the operation lasted longer than three hours, and the major surgical intervention were important in the occurrence of intraoperative pressure injury (p=0.001). In determining the risk of intraoperative pressure injury, it is important to know the individual characteristics of the patients as well as the risks specific to the surgery. Intraoperative pressure injury is an important complication that operating room nurses need to detect early and take precautions in patients undergoing major surgery.Publication Open Access Ameliyathane hemşirelerinin delici kesici aletler ile yaralanma durumu, nedenleri ve önlemleri(Bezmialem Vakıf Uniersity) Dağcı, Mahmut; Sayın, YazileIntroduction: Penetrators and sharps injuries, PSI is a factor affecting the healthcare workers, is seen high among operating room nurses. This research was planned and conducted to examine the conditions and precautions that operating room nurses cause to PSI. Method: The descriptive and cross-sectional study was conducted between January 2017-May 2018 in istanbul european side with 463 volunteer nurses in 27 different hospitals. Operating rooms had at least 10 nurses and were compliance with the Turkish Standards Institute Clean Rooms Standard. The data collected with two data forms which prepared with knowledge of literature. IBM SPSS 22.0 used for data analysis and P<0.05 was significance value. Findings: Participants were 18-61 years old, (avg.35.9 +- 0.84), 63.7% had bachelor degree and above, 80.8% had nurse title, 68.9% said they had PSI. There were significantly different for PSI (p<0.05) women, married and had low educational level, working in university hospitals with deep invasive intervention and using protective equipment. Participants reported that 54.8% of the injuries were performed in the right hand and primary cause was exchanging instruments between nurse and surgeon, secondary was assisting surgeon. Most of the participants (37.1%)were injured by the suture material.After the injury, 83.0% of the participants were made right attempt to the wound. 26.6% of the participants, come across to infected PSI, while only 60.2% reported it. 71.4% who didn't report said, reporting wasn't working and wasn't significant. Conclusion: Personal and occupational characteristics of health workers working as nurses with inadequate physical and environmental factors of the operating theater are effective in the high PSI rate.Publication Open Access Anti-oksidan doğal bileşiklerin kemoterapi ajanı paclitaxel ile birlikte nano misellere yüklenmesinin etkinlik ve toksisite profili açısından in -vitro ortamda gözlenen olası değişiklikler(2019) Öztenekeci, Burcu; Bahadori, FatemehChemotherapeutic agents used in chemotherapy treatment not only affect cancer tumors, but also can cause toxic effects in healthy areas. These substances show side effects from time to time due to their oxidation effect. From this point of view, it is sometimes recommended that patients consume antioxidant natural products during chemotherapy in cancer treatment. However, these antioxidant substances may reduce the oxidation effect of the chemotherapy agent at the cancer tumor site and prevent the chemotherapy agent from acting fully. This issue should be clarified. From this point, the antioxidant effect of curcumin, quercetin and rosmarinic acid compounds were applied to cancer cells together with chemotherapy agent paclitaxel and the effect of this agent was investigated. For this purpose, the natural antioxidants compounds were loaded into nano-carriers and the effect of paclitaxel on breast cancer cells was investigated. The reason for the loading of natural antioxidants in the nano-carrier is that these substances can be applied to the cells at a high rate by removing their low solubility property in water. To this end, poly lactide co-glycolide (PLGA) nano-micelles were used. The water-soluble commercial form of Paclitaxel was applied to the cells. The nano-formulation of each antioxidant was prepared separately using the o/w method. Briefly, the antioxidant and PLGA were dissolved together in acetone and slowly dropped into water containing the surfactant. The organic solvent was removed at room temperature by stirring overnight. The size of the nanofomulations obtained were determined by Dynamic Light Scattering (DLS) method. The antioxidants were loaded into the nao-carrier with increasing concentrations, and the highest concentration with no aggregate, ie the formulation in which the entire compound was loaded into the micelle, was considered as the optimized formulation. The concentration of paclitaxel equal to the IC 50 value was applied to MCF-7 human breast cancer cells with various concentrations of nano-antioxidants and changes in cell viability were observed. Cell viability was measured by Sulforhodamine B assay. In addition, nano-anti-oxidant was applied to the cells together with paclitaxel, 1 hour before paclitaxel and 1 hour after paclitaxel, and the effect of time of administration on the results was investigated. In conclusion, it was observed that curcumin significantly reduced the anti-tumor effect of Paclitaxel. Quercetin reduced the anti-tumor effect of paclitaxel in a dose-dependent manner. There was no significant effect of rosmarinic acid. It was observed that the application time had no function on the change of these effects. Ultimately, the bioavailability of antioxidant and its concentration in the blood will remain unknown unless the concentration of the antioxidant in the blood circulation is known. This will cause the unknown direction of the natural antioxidant on affecting the effect of chemotherapy on the tumor site. From this it can be clearly concluded that antioxidants should not be used during cancer treatment unless the xiv effect of the anti-oxidant on the chemotherapy agent and ultimately its negative impact on the growth of the cancer tumor is fully understoodPublication Open Access Artvin ormanlarında yangınların dağılımı ve büyük yangınların değerlendirilmesi / Distribution of fires and evaluation of large fires in Artvin forestsSAVAŞ, KÜBRA; ÖZDER, ACLANBu çalışmada, 01.01.2015-31.12.2021 tarihleri arasında Artvin Orman Bölge Müdürlüğü'nde meydana gelen orman yangınlarının genel durumu, sayı ve alan bakımından Orman İşletme Şefliklerine ve yerleşim yerlerine göre gösterdikleri dağılımı, iklim verilerinin yangın sayı ve alanına yaptığı etkiyi, yangınlara karşı alınan tedbirler ve müdahale usullerinin nasıl yapıldığını ve bunların etkinlikleri incelenmiştir. Araştırmanın evrenini, Artvin ilinde 01.01.2015-31.12.2021 tarihleri arasında meydana gelen orman yangınlarına ait tüm raporlar oluşturmaktadır. Veri girişi ve analizinde "Statiscial Package for Social Sciences (SPSS) 25" programı kullanılmıştır. Analizlerde kayıt altına alınan değişkenlere ait sayı ve yüzde dağılımları yapılmış ve veriler arasındaki anlamlı ilişki düzeyine bakmak için Pearson Corelasyon değerlerine bakılmıştır. Araştırmada 84 adet orman yangını detaylı incelenmiştir. Borçka en fazla orman yangınının görüldüğü (n=29 , %35) ilçe olarak tespit edilmiştir. 7 Yıl boyunca meydana gelen orman yangınları en fazla ilkbahar mevsiminde (n=28, %33,33), Mart ayında (n=12, %14, 29), Çarşamba günleri (n=16, %19,05) ve 12:00-17:59 saatleri (n=54, %64,29) arasında meydana geldiği saptanmıştır. 00:00-05:59 Saatleri arasında hiç yangın olmamıştır. Orman yangınları sonucu toplam 70,22ha ormanlık alan yanarak yok olmuştur. Borçka en çok alanın yandığı (n=18,237, %26) ilçe olmuştur. Orman yangınlarının çıkış sebeplerinin sırası ile (n=40, %47,62) en fazla ihmal ve dikkatsizlik, (n=18, %21,43) faili meçhul, (n=17, %20,24) doğal olaylar (yıldırım), (n=5, %5,95) kaza (elektrik hattı), (n=4, %4,76) bilinmeyen sebeplerden meydana geldiği tespit edilmiş ve nedeni bilinmeyen sebepler ile beraber (n=62, %73,81) yangının en çok çıkış sebebi olarak insan faktörü tespit edilmiştir. Araştırmada yanma türü en fazla örtü yangını (n=81, %96,43), tepe ve örtü yangını karışık olarak (n=3, %3,57) gerçekleşmiştir. Orman yangınlarında meydana gelen yangınlar ağaç türü bakımından değerlendirildiğinde en çok yanan ağaç türü (n=17, 20,24) sarıçam, en az yanan ağaç türleri (n=1, %1,19) karaçam, (n=1, %1,19) gürgen, (n=1, %1,19) ardıç olarak belirlenmiştir. Artvin Orman Bölge Müdürlüğü'nde meydana gelen yangınlarındaki aylık toplam yağışın yanan alan ve söndürme sürelerine olan etkisi incelenmiş ve aynı yönde ilişki olduğu görülmüş, toplam yağış toplam yanan alan ve söndürme süresine aynı yönde etki ettiği tespit edilmiştir. Ayrıca aylık toplam yağışın söndürme süresi üzerine etkisi bakılmış ve söndürme süresine aynı yönde etki ettiği belirlenmiştir. Anahtar Kelimeler: Müdahale, Orman yangını, yangınların dağılımı, İklim Faktörü, ArtvinPublication Open Access Aydın Büyükşehir Belediyesi İtfaiye Daire Başkanlığı çalışanlarında uyku kalitesi ve iş performansı arasındaki ilişkinin incelenmesiDEMİR, Tuğba; ERDOĞAN, ÖzcanThis research was conducted descriptively and cross-sectionally to investigate the relationship between sleep quality and work performance in employees of the Aydın Metropolitan Municipality Department of Fire Service. The study was carried out with 187 people working in the Fire Department of Aydın Metropolitan Municipality between 01.09.2019-15.12.2019. Data were collected using Personal Information Form, Pittsburgh Sleep Quality Index (PSQI) and Job Performance Scale. Descriptive statistics were used to evaluate the collected data.The mean age of the participants was 34.36 ± 8.18 and all of them were male. 21.8% of them are undergraduates, 34.1% of them have associate degree, 26.8% of them are high school and 17.3% of them are in other education group. 59.2% are married. 14.5% of the employees are office personnels, 67.6% are firefighters, 13.4% are drivers and 4.5% are technicians. 20.1% of them are constantly shifting during the day and 79.9% of them are shifting day and night. 79.3% of the workers stated that changes in working hours caused sleep problems. 15.6% of the employees reported sleep quality as excellent, 40.8% almost good, 26.8% almost poor while 16.8% of the employees reported the sleep quality as very poor during the last month. When the distribution of information about the frequency of having problems in working voluntarily during the last month was analyzed, 29.1% of the employees reported never, 27.9% reported having problems less than 1 in a week, 31.8% twice a week and 11.2% reported 3 or more in a week. The job performances of the survey participants were generally medium (3.73). No statistically significant relationship was found between the job performances and age of the employees (p = .388> .05). Educational situations do not significantly affect job performances. The job performance of those who do not think that the change in working hours causes sleep problems is significantly higher than the group who think it does. For those who with very good sleep quality job performances are statistically significantly higher than those that report almost poor and very poor sleep quality. In addition, the work performance of those who have almost good sleep quality is significantly higher than those with very poor sleep quality. It was concluded that poor sleep quality had a negative effect on the performance of the firefighters. Frequent evaluation of sleep quality is thought to affect the work performance of shifted fire brigade personnel.