Publication:
Effects of shock waves on oxidative stress in parotid gland of rat

No Thumbnail Available
Date
2014-06-01
Authors
TURAN, Mahfuz
Garca, M. Fatih
Kavak, Servet
Gecit, Ilhan
Meral, Ismail
Demir, Halit
Cegin, Bilal
Bektaş, Hava
Cankaya, Hakan
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Sustainable Development Goals
Organizational Units
Journal Issue
Abstract
This study was designed to investigate whether extracorporeal shock wave lithotripsy (ESWL) exposure to parotid gland produces an oxidative stress in parotid glands of rats. Twelve male Wistar-albino rats, 6 months of age with an average body weight of 250-300 g, were divided randomly into two groups, each consisting of six rats. The animals in the first group did not receive any treatment and served as control. The left parotid glands of animals in group 2 (ESWL treated) received a thousand 18 kV shock waves after anesthetizing the rats with 50 mg/kg of ketamine. The animals in both groups were killed 72 hours after the ESWL treatment, and the parotid glands were harvested for the determination of lipid peroxidation product malondialdehyde (MDA), antioxidant glutathione (GSH) levels and the activities of antioxidant enzymes such as superoxide dismutase (SOD), GSH-Px and catalase (CAT). It was found that MDA level increased in parotid glands of rats after the ESWL treatment. The SOD, GSH-Px and CAT enzyme activities, and the level of antioxidant GSH decreased in parotid gland of rats after the ESWL treatment. It was concluded that short-term ESWL treatment caused an increase in the free radical production and a decrease in the antioxidant enzyme activity in parotid glands of ESWL-treated rats.
Description
Keywords
Citation
Garca M. F. , Kavak S., Gecit I., Meral I., Demir H., TURAN M., Cegin B., Bektaş H., Cankaya H., -Effects of shock waves on oxidative stress in parotid gland of rat-, TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.30, ss.454-458, 2014