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dc.contributor.authorTak, Ali Zeynel Abidin
dc.contributor.authorSengul, YILDIZHAN
dc.contributor.authorKaradag, Ayse Sevgi
dc.date.accessioned2019-10-05T12:50:08Z
dc.date.available2019-10-05T12:50:08Z
dc.date.issued2018-06-01
dc.identifier10.1016/s0367-326x(00)00244-6
dc.identifier.urihttps://hdl.handle.net/20.500.12645/686
dc.description.abstractThe pathology of essential tremor (ET) and underlying mechanisms of the disease are still unclear, but an increasing amount of research has been conducted on the subject. Discussions are ongoing about ET-s definition as a neurodegenerative disease. Optic coherence tomography (OCT) provides a window to the brain where direct visualization of central nervous system (CNS) changes may be possible, and it can help us to develop a new point of view on ET. The goal of this study was to examine OCT parameters in ET. 40 ET patients and 40 healthy controls, i.e., a total of 160 eyes were evaluated. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and choroid thinning were analyzed using spectral domain OCT. The mean age was 25.77 +/- 8.98 in the ET group and 27.25 +/- 8.22 in the control group. We found a decreased global RNFL thickness for both eyes in ET patients. All GCL and IPL thickness parameters were lower in the patients with ET (P < 0.001, P 0.03). Choroid was significantly thicker in ET patients than the controls (P < 0.001). Our study-s results suggest that the usefulness of OCT in detecting neurodegeneration in ET. RNFL, GCL, IPL measurements are highly reproduced findings of neurodegeneration. Increased choroid volume may indicate neuroinflammation. Eyes in ET may shed light on nature of the disease, and may be used as a diagnostic tool.
dc.subjectTak A. Z. A. , Sengul Y., Karadag A. S. , -Evaluation of thickness of retinal nerve fiber layer, ganglion cell layer, and choroidal thickness in essential tremor: can eyes be a clue for neurodegeneration?-, ACTA NEUROLOGICA BELGICA, cilt.118, ss.235-241, 2018
dc.titleEvaluation of thickness of retinal nerve fiber layer, ganglion cell layer, and choroidal thickness in essential tremor: can eyes be a clue for neurodegeneration?
dc.typeArticle
local.avesis.response556
local.article.journalnameFITOTERAPIA
local.org.facultyTıp Fakültesi
dc.identifier.wosWOS:000433236400012
dc.identifier.scopus85032380318
dc.identifier.doi10.1007/s13760-017-0852-l
local.publication.isinternational1


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