Person: ŞENGÜL, YILDIZHAN
Now showing 1 - 10 of 26
- PublicationMetadata onlyHuzursuz bacak hastalarında fatig, depresif belirtiler ve anskiyete düzeylerinin değerlendirilmesi.(2017-11-30) Şengül, Hakan Serdar; ŞENGÜL, YILDIZHAN; YILDIZ, GÜLSEN; ŞENGÜL, YILDIZHAN; BABACAN YILDIZ, GÜLSEN
- PublicationMetadata onlySleep disturbances in essential tremor: an investigation of associated brain microstructural changes using diffusion tensor imaging(2021-05-01T00:00:00Z) Sengul, Yildizhan; Temur, Hafize Otcu; Sengul, Hakan S.; Ustun, Ismet; Radler, Keith; ALKAN, ALPAY; Louis, Elan D.; ŞENGÜL, YILDIZHAN; ÜSTÜN, İSMET; ALKAN, ALPAYEssential tremor (ET) is a complex, neurodegenerative disorder that includes motor and non-motor symptoms. There is growing interest in its non-motor features, including sleep disturbances (SD). There are no studies evaluating the brain structural correlates of SD in ET. We aimed to identify brain microstructural changes related to SD in ET. SD was evaluated using the Pittsburg sleep quality index (PSQI). Diffusion tensor imaging (DTI), with reported measures being fractional anisotropy (FA) and apparent diffusion coefficient (ADC), was used to evaluate microstructural brain changes. DTI data were compared in ET patients with vs. without SD. The mean age of 40 ET patients was 49.20 +/- 21.06 years. The mean PSQI score was 6.13 +/- 3.99, and 18 (45.0%) patients had SD. The mean PSQI score of patients with vs. without SD was 9.78 +/- 2.98 vs. 3.14 +/- 1.28 (p < 0.001). Patients with vs. without SD differed significantly with respect to several DTI findings: right (R) superior cerebellar peduncle ADC (p = 0.04), left (L) dorsolateral prefrontal cortex FA (p < 0.01), L frontooccipital fasciculus FA (p = 0.02), R posterior corona radiata (RPCR) FA (p = 0.01), L posterior corona radiata FA (p = 0.04), R posterior thalamic radiation (RPTR) FA (p = 0.02), and fornix FA (p = 0.03) Significant correlations between PSQI scores and RPCR FA (r = - 0.50, p = 0.02) and RPTR FA (r = - 0.67, p = 0.001) were also observed. Our findings suggest that certain brain changes may be associated with the clinical expression of SD in ET. These changes are discussed in terms of their possible neuroanatomical and physiological significance.
- PublicationMetadata onlyA comparison between rate of nonmotor symptom development in essential tremor and Parkinson-s disease.(2015-09-01T00:00:00Z) BAKIM, BAHADIR; Sengul, YILDIZHAN; SENGUL, HS; Sural, MK; FORTA, H; ŞENGÜL, YILDIZHAN
- PublicationMetadata onlyEvaluation of thickness of retinal nerve fiber layer, ganglion cell layer, and choroidal thickness in essential tremor: can eyes be a clue for neurodegeneration?(2018-06-01) Tak, Ali Zeynel Abidin; Sengul, YILDIZHAN; Karadag, Ayse Sevgi; ŞENGÜL, YILDIZHANThe pathology of essential tremor (ET) and underlying mechanisms of the disease are still unclear, but an increasing amount of research has been conducted on the subject. Discussions are ongoing about ET-s definition as a neurodegenerative disease. Optic coherence tomography (OCT) provides a window to the brain where direct visualization of central nervous system (CNS) changes may be possible, and it can help us to develop a new point of view on ET. The goal of this study was to examine OCT parameters in ET. 40 ET patients and 40 healthy controls, i.e., a total of 160 eyes were evaluated. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and choroid thinning were analyzed using spectral domain OCT. The mean age was 25.77 +/- 8.98 in the ET group and 27.25 +/- 8.22 in the control group. We found a decreased global RNFL thickness for both eyes in ET patients. All GCL and IPL thickness parameters were lower in the patients with ET (P < 0.001, P 0.03). Choroid was significantly thicker in ET patients than the controls (P < 0.001). Our study-s results suggest that the usefulness of OCT in detecting neurodegeneration in ET. RNFL, GCL, IPL measurements are highly reproduced findings of neurodegeneration. Increased choroid volume may indicate neuroinflammation. Eyes in ET may shed light on nature of the disease, and may be used as a diagnostic tool.
- PublicationMetadata onlySleep disturbances and excessive daytime sleepiness in migraine: A comparison between comorbidities and disability(2015-01-01T00:00:00Z) Sengul, YILDIZHAN; SENGUL, Hakan S.; Bakim, Bahadir; YUCEKAYA, Sevda K.; YUCEL, Selma; AKGUN, Mucella; ŞENGÜL, YILDIZHANMany studies have investigated the association between headache and sleep disorders, but few have focused on migraine. The goal of this study was to evaluate sleep disturbance and excessive daytime sleepiness (EDS) in relation to migraine disability. 120 migraine patients who were diagnosed according to The International Classification of Headache Disorders-II and 45 healthy controls were recruited for the study. All participants completed the Pittsburg Sleep Quality Index (PSQI), the Epworth Sleepiness Scale, Beck Depression Inventory and Beck Anxiety Scale. Migraineurs completed Migraine Disability Assessment Scale (MIDAS) and Visual Analog Scale. The prevalence of poor sleep was 83.3% in the patients and 22.2% in the controls. All PSQI subgroup scores were higher for the patients than the controls except Hours asleep. EDS was more prominent in the patient group (19.2% vs 2.2%). In conclusion, sleep disturbance, EDS, anxiety, and depressive symptoms were detected more commonly in migraine patients and were correlated with the migraine-related disability. The results of multivariate regression analysis indicated that EDS and sleep disturbance were the most effective factors on disability.
- PublicationMetadata onlyDiabetik polinöropatide beden farkındalık tedavisinin alt ekstremite fonksiyonu ve denge üzerine etkisi: olgu sunumu(2018-03-31) ALPAY, KÜBRA; DENİZOĞLU KÜLLİ, HİLAL; DURGUT, ELİF; ŞENGÜL, YILDIZHAN; ALPAY, KÜBRA; DENİZOĞLU KÜLLİ, HİLAL; DURGUT, ELİF; ŞENGÜL, YILDIZHAN
- PublicationMetadata onlyCognitive Impairment in Young Multiple Sclerosis and Essential Tremor Patients: A Comparative Study(2016-09-01T00:00:00Z) Sengul, Hakan Serdar; ŞENGÜL, YILDIZHAN; Yucel, Selma; Forta, Hulki; ŞENGÜL, YILDIZHANObjective: In multiple sclerosis (MS); memory, attention, information processing speed, and executive function deficits associated with cortical demyelination and atrophy can be seen in the early phases. In essential tremor (ET) cognitive impairment associated with cerebral-thalamocortical pathway dysfunction, which is characterized by visuospatial functions, verbal memory, and executive functions were seen. We aimed to evaluate cognitive impairment in patients with MS and ET, and to compare the features of impairment.
- PublicationMetadata only. Kronik migrende ak madde lezyonları orta serebral arter ortalama akım hızları ve vasküler reaktivite ile ilişkili midir?(2017-11-30) USLU, FERDA; GÖKÇAL, ELİF; ŞENGÜL, YILDIZHAN; KARAKAYALI, ZEHRA CEMRE; UZUN, MUSTAFA; ASIL, TALİP; GÖKÇAL, ELİF; ŞENGÜL, YILDIZHAN; KARAKAYALI, ZEHRA CEMRE; USLU, FERDA; ASİL, TALIP
- PublicationMetadata onlyEsansiyel Tremor Hastalarında Kognitif Bozulmanın Düzeyiyle Beyin Mikroyapısal Değişikliklerinin Diffuzyon Tensor Manyetik Rezonans Görüntüleme ile Değerlendirilmesi ve Korelasyonlarının Saptanması(2018-12-06T00:00:00Z) ŞENGÜL, YILDIZHAN; OTÇU TEMUR, HAFİZE; ÇORAKÇI, ZEYNEP; ŞENGÜL, YILDIZHAN; OTÇU TEMUR, HAFİZE; ÇORAKÇI, ZEYNEP
- PublicationOpen AccessInvestigation and Clinical Importance of Obsessive and Compulsive Signs Among Patients with Restless Legs Syndrome(2019-07-01T00:00:00Z) ŞENGÜL, YILDIZHAN; YILMAZ, Onur; Sengul, Hakan Serdar; PARLAKKAYA, FATMA BÜŞRA; ÖZTÜRK, AHMET; ŞENGÜL, YILDIZHAN; YILMAZ, ONUR; PARLAKKAYA, FATMA BÜŞRA; ÖZTÜRK, AHMETObjective: The purpose of this study was to examine obsessive and compulsive signs among patients with Restless Legs syndrome (RLS), to compare the results with healthy controls and to investigate clinic importance of those signs.
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