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Effect of short-term treatment with levosimendan on oxidative stress in renal tissues of rats

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Tarih
2014-02-01
Yazar
Gecit, Ilhan
Bektaş, Hava
YUKSEL, Mehmet Bilgehan
BASEL, Halil
Kavak, Servet
Meral, Ismail
Demir, Halit
Gumrukcuoglu, Hasan Ali
Danışman
Türü
Article
Üst veri
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Özet
The aim of this study is to evaluate the influences of short-term treatment with levosimendan (chemical formula: C14H12N6O) on oxidative stress and some trace element levels in renal tissues of healthy rats. A total of 20 male Wistar-albino rats were randomly divided into two groups, each consisting of 10 rats. Animals in the first group were not treated with levosimendan and served as control. Animals in the second group were injected intraperitoneally with 12 mu g/kg levosimendan and served as levosimendan group. Animals in both the groups were killed 3 days after the treatment, and their kidneys were harvested for the determination of tissue oxidant/antioxidant statues and trace element levels in renal tissues. The tissue malondialdehyde level was significantly (p < 0.001) lower in levosimendan group than in controls. The protective enzyme activities such as superoxide dismutase, catalase, and glutathione peroxidase and antioxidant glutathione level were significantly (p < 0.001) higher in levosimendan group than in controls. It was concluded that levosimendan reduced oxidative stress by avoiding lipid peroxidation and production of reactive oxygen species, and overactivating and/or increasing the protective antioxidant enzyme levels in renal tissues of rats. It is supposed that this experimental study provides beneficial data for clinicians in the management of renal tissue damage related to obstruction and/or ischemia.
Konu
Gecit I., Kavak S., YUKSEL M. B. , BASEL H., Bektaş H., Gumrukcuoglu H. A. , Meral I., Demir H., -Effect of short-term treatment with levosimendan on oxidative stress in renal tissues of rats-, TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.30, ss.47-51, 2014
Bağlantı
https://hdl.handle.net/20.500.12645/6456
Koleksiyonlar
  • PubMed İndeksli Yayın Koleksiyonu [3700]
  • Scopus İndeksli Yayınlar Koleksiyonu [4458]
  • WoS İndeksli Yayınlar Koleksiyonu [5221]
  • Yayınlar - Eserler [10056]

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BEZMIALEM VAKIF UNIVERSITY

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Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
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