Relationship of CTLA4 and CD28 polymorphisms with lung involvement, HRCT findings and pulmonary function tests in Turkish patients with ankylosing spondylitis
Date
2017-09-01Author
Uysal, OmerSezer, Murat
Yaylim, Ilhan
Kart, Levent
Rezvani, AYLİN
Okyaltirik, FATMANUR
GÜLER, Mustafa
Bayram, MEHMET
SÖZGEN, Hatice
YAKAR, Fatih
Ozcelik, Hatice Kutbay
Turan, Saime
Akkoyunlu, Muhammet Emin
Ozkan, Nazli Ezgi
Advisor
Type
Metadata
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Background and AimsAnkylosing spondylitis (AS) is a multisystem disorder with ocular, pulmonary, and cardiovascular involvement. The incidence of pulmonary involvement varies from 1 to 52%. Abnormal T-cell function-derived immune responses are involved in AS pathogenesis. Numerous genes such as CTLA4 and CD28 control T-cell functions. In this study, we aimed to address the relationship between CTLA4 and CD28 polymorphisms and lung involvement in Turkish patients with AS.
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