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New spectrophotometric and spectrofluorimetric methods for the determination of angiotensin II receptor antagonists in tablets and plasma

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Date
2013-06-01
Author
Tekkeli, S. E. Kepekci
Onal, A.
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Type
Article
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Abstract
Spectrophotometric and spectrofluorimetric methods for the determination of five Angiotensin II type 1 receptor antagonists in tablets and plasma have been developed and optimized. The spectrophotometric method involves the addition of a measured excess of bromate-bromide in HCl medium and subsequent estimation of the residual bromine by reacting with a fixed amount of methyl orange. The spectrofluorimetric method depends on the oxidation of the drugs with cerium(IV) and subsequent monitoring of the fluorescence of the induced cerium(III) at 365 nm with excitation at 255 nm. Both of the proposed methods were successfully applied to the determination of the investigated drugs in their pure forms and pharmaceutical preparations. Besides, the spectrofluorimetric method was applied to the determination of irbesartan and telmisartan in biological fluids with good accuracy and precision.
Subject
Tekkeli S. E. K. , Onal A., -New spectrophotometric and spectrofluorimetric methods for the determination of angiotensin II receptor antagonists in tablets and plasma-, JOURNAL OF ANALYTICAL CHEMISTRY, cilt.68, ss.501-509, 2013
URI
https://hdl.handle.net/20.500.12645/3591
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  • İstanbul Üniversitesi
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  • Yayınlar - Eserler

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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS