Show simple item record

dc.contributor.authorAltinok, A.
dc.contributor.authorCoskun, Z. M.
dc.contributor.authorKaraoglu, K.
dc.contributor.authorBOLKENT, Şehnaz
dc.contributor.authorAkkan, Ahmet Gökhan
dc.contributor.authorOzyazgan, S.
dc.date.accessioned2021-01-21T20:59:21Z
dc.date.available2021-01-21T20:59:21Z
dc.date.issued2015-03-01T00:00:00Z
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28085
dc.description.abstractObjective: In this study, we investigated the possible effect of Delta(9)-tetrahydrocannabinol (THC), a peroxisome proliferator-activated receptor gamma (PPAR.) agonist, on metabolic control and vascular complications of diabetes in streptozotocin/nicotinamide (STZ/NIC) induced type 2 diabetes mellitus. Material and methods: Type 2 diabetes was induced with 65 mg/kg STZ, 15 minute later 85 mg/kg NIC was given intraperitoneally (i.p.) to rats. Three days after diabetes induction, THC (3 mg/kg/day, i.p.) was given for 7 days to diabetic rats. Body weight and plasma glucose levels of rats were measured in all groups before and at the end of 3 weeks after diabetes induction. Acetylcholine (Ach) and sodium nitroprusside (SNP) potency and maximum relaxant effects were calculated on aortic rings pre-contracted with noradrenaline (NA). Results: At the end of 3 weeks, blood glucose levels of diabetic group significantly increased in comparison with the control group. Increased plasma glucose levels were significantly decreased by the treatment of THC. Ach induced relaxation was impaired whereas endothelium-independent relaxation to SNP was unaffected on isolated diabetic rat aorta. THC treatment enhanced Ach induced relaxation on diabetic rat aortas. Discussion: These results suggested that THC improved endothelium-dependent relaxation in STZ/NIC induced diabetic rat aorta and that these effects were mediated at least in part, by control of hyperglycemia and enhanced endothelial nitric oxide bioavailability.
dc.subjectAltinok A., Coskun Z. M. , Karaoglu K., BOLKENT Ş., Akkan A. G. , Ozyazgan S., -Delta(9)-tetrahydrocannabinol treatment improved endothelium-dependent relaxation on streptozotocin/nicotinamide-induced diabetic rat aorta-, ACTA PHYSIOLOGICA HUNGARICA, cilt.102, ss.51-59, 2015
dc.titleDelta(9)-tetrahydrocannabinol treatment improved endothelium-dependent relaxation on streptozotocin/nicotinamide-induced diabetic rat aorta
dc.typeArticle
dc.identifier.wosWOS:000351869500005
dc.identifier.scopus84926372406
dc.identifier.doi10.1556/aphysiol.102.2015.1.5
dc.identifier.pubmed25804389
local.publication.isinternational1


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record