Anticholinergic and antioxidant activities of avocado (Folium perseae) leaves - phytochemical content by LC-MS/MS analysis
Date
2020-01-01Author
Bingol, ZeynebeDURMAZ, LOKMAN
Akincioglu, Hulya
GÖREN, AHMET CEYHAN
Kaya, Ruya
Kose, Leyla Polat
GÜLÇİN, İlhami
Alwasel, Saleh H.
KÖKSAL, EKREM
Advisor
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In the first stage of the manuscript, we aimed to examine antioxidant capacity and anticholinergic properties of avocado (Folium perseae) leaves. Avocado leaf was extracted by water (WEFP) and ethyl alcohol (EEFP) and antioxidant activity was determined using by several antioxidant assays including DPPHGreek ano teleia and ABTS(center dot+)radical scavenging assays, Cu2+-Cu(+)reducing, Fe3+-Fe(2+)reducing, and FRAP reducing activities. Avocado leaf extracts demonstrated antioxidant activity and anticholinergic activities, while alpha-tocopherol, BHT, trolox, and BHA were used as positive antioxidant controls. In the second part of this study, the inhibition effects of WEFP and EEFP were valuated against acetylcholinesterase and butyrylcholinesterase enzymes, which catalyze the breakdown of choline esters (i.e. neurotransmitters). This study obviously showed that avocado leaf extracts had effective antioxidant, antiradical, and anticholinergic influences.
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