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A challenging case of concurrent multiple sclerosis andanaplastic astrocytoma

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44- A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma.pdf (1.495Mb)
Tarih
2019-08-01
Yazar
Sinclair, Georges
Shamikh, Alia
HATİBOĞLU, MUSTAFA AZİZ
Johnstone, Philippa
Alsaffar, Yahya
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Article
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Özet
Background: Cases of gliomas coexisting with multiple sclerosis (MS) have been described over the past few decades. However, due to the complex clinical and radiological traits inherent to both entities, this concurrent phenomenon remains difficult to diagnose. Much has been debated about whether this coexistence is incidental or mirrors a poorly understood neoplastic phenomenon engaging glial cells in the regions of demyelination. Case Description: We present the case of a 41-year-old patient diagnosed with a left-sided frontal contrast enhancing lesion initially assessed as a tumefactive MS. Despite systemic treatment, the patient gradually developed signs of mass effect, which led to decompressive surgery. The initial microscopic evaluation demonstrated the presence of MS and oligodendroglioma; the postoperative evolution proved complex due to a series of MS-relapses and tumor recurrence. An ulterior revaluation of the samples for the purpose of this report showed an MS-concurrent anaplastic astrocytoma. We describe all relevant clinical aspects of this case and review the medical literature for possible causal mechanisms. Conclusion: Although cases of concurrent glioma and MS remain rare, we present a case illustrating this phenomenon and explore a number of theories behind a potential causal relationship.
Konu
Anaplastic astrocytoma
Gamma knife radiosurgery
Magnetic resonance imaging
Multiple sclerosis
Oligodendroglioma
Tumefactive multiple sclerosis
Bağlantı
https://openaccess.bezmialem.edu.tr/handle/20.500.12645/14058
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763678/
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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

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