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A challenging case of concurrent multiple sclerosis andanaplastic astrocytoma

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dc.contributor.authorSinclair, Georges
dc.contributor.authorAlsaffar, Yahya
dc.contributor.authorJohnstone, Philippa
dc.contributor.authorHATİBOĞLU, MUSTAFA AZİZ
dc.contributor.authorShamikh, Alia
dc.contributor.institutionauthorHATİBOĞLU, MUSTAFA AZİZ
dc.date.accessioned2020-02-10T20:59:12Z
dc.date.available2020-02-10T20:59:12Z
dc.date.issued2019-08-01T00:00:00Z
dc.description.abstractBackground: Cases of gliomas coexisting with multiple sclerosis (MS) have been described over the past few decades. However, due to the complex clinical and radiological traits inherent to both entities, this concurrent phenomenon remains difficult to diagnose. Much has been debated about whether this coexistence is incidental or mirrors a poorly understood neoplastic phenomenon engaging glial cells in the regions of demyelination. Case Description: We present the case of a 41-year-old patient diagnosed with a left-sided frontal contrast enhancing lesion initially assessed as a tumefactive MS. Despite systemic treatment, the patient gradually developed signs of mass effect, which led to decompressive surgery. The initial microscopic evaluation demonstrated the presence of MS and oligodendroglioma; the postoperative evolution proved complex due to a series of MS-relapses and tumor recurrence. An ulterior revaluation of the samples for the purpose of this report showed an MS-concurrent anaplastic astrocytoma. We describe all relevant clinical aspects of this case and review the medical literature for possible causal mechanisms. Conclusion: Although cases of concurrent glioma and MS remain rare, we present a case illustrating this phenomenon and explore a number of theories behind a potential causal relationship.en
dc.identifier.citationSinclair G., Alsaffar Y., Johnstone P., HATİBOĞLU M. A. , Shamikh A., -A challenging case of concurrent multiple sclerosis andanaplastic astrocytoma-, Surgical Neurology International, cilt.10, ss.1-8, 2019
dc.identifier.doi10.25259/sni_176_2019
dc.identifier.pubmed31583163
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/14058
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763678/
dc.identifier.yoksis5236385
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectAnaplastic astrocytoma
dc.subjectGamma knife radiosurgery
dc.subjectMagnetic resonance imaging
dc.subjectMultiple sclerosis
dc.subjectOligodendroglioma
dc.subjectTumefactive multiple sclerosis
dc.titleA challenging case of concurrent multiple sclerosis andanaplastic astrocytoma
dc.typeArticle
dspace.entity.typePublication
local.avesis.id54566857-3c2a-45ee-b7c2-6a0abb00499a
local.publication.isinternational1
relation.isAuthorOfPublicationdb1f8830-0234-4e6a-8b53-c1176e6da242
relation.isAuthorOfPublication.latestForDiscoverydb1f8830-0234-4e6a-8b53-c1176e6da242
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