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dc.contributor.authorBilici, A
dc.contributor.authorSelcukbiricik, F
dc.contributor.authorSeker, MESUT
dc.contributor.authorOven, BB
dc.contributor.authorOlmez, OF
dc.contributor.authorYildiz, O
dc.contributor.authorOlmuscelik, O
dc.contributor.authorHamdard, J
dc.contributor.authorAcikgoz, O
dc.contributor.authorCakir, A
dc.contributor.authorKapran, Y
dc.contributor.authorBalik, E
dc.contributor.authorOncel, M
dc.date.accessioned2020-02-02T20:59:07Z
dc.date.available2020-02-02T20:59:07Z
dc.date.issued2019-01-01T00:00:00Z
dc.identifier.citationBilici A., Selcukbiricik F., Seker M., Oven B., Olmez O., Yildiz O., Olmuscelik O., Hamdard J., Acikgoz O., Cakir A., et al., -Prognostic Significance of Metastatic Lymph Node Ratio in Patients with pN3 Gastric Cancer Who Underwent Curative Gastrectomy.-, Oncology research and treatment, cilt.42, ss.209-216, 2019
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/14045
dc.identifier.urihttps://www.karger.com/Article/FullText/496746
dc.description.abstractBackground: Lymph node involvement is an important prognostic factor in patients with gastric cancer. The aim of this study was to determine the prognostic significance of metastatic lymph node ratio (MLNR) and compare it to the number of lymph node metastasis in pN3 gastric cancer. Methods: We retrospectively analyzed 207 patients with pN3 gastric cancer who had undergone radical gastrectomy. Prognostic factors and MLNR were evaluated by univariate and multivariate analysis. Results: An MLNR of 0.75 was found to be the best cut-off value to determine the prognosis of patients with pN3 gastric cancer (p = 0.001). The MLNR was significantly higher in patients with large-sized and undifferentiated tumors, vascular, lymphatic and perineural invasion, and total gastrectomy. In multivariate analysis, MLNR (p = 0.041), tumor differentiation (p = 0.046), and vascular invasion (p = 0.012) were found to be independent prognostic factors for disease-free survival, while both MLNR (p < 0.001) and pN stage (p = 0.002) were independent prognostic indicators, as was tumor size, for overall survival. There was significant difference with respect to the recurrence patterns between MLNR groups. Lymph node and peritoneal recurrences were significantly higher in patients with MLNR > 0.75 compared to the MLNR < 0.75 group (p < 0.05). However, recurrence patterns were similar between pN3a and pN3b. Conclusion: Our results showed that MLNR was a useful indicator to determine the prognosis and recurrence patterns of patients with radically resected gastric cancer. Moreover, MLNR is a beneficial and reliable technique for evaluating lymph node metastasis.en
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectGastric cancer
dc.subjectMetastatic lymph node ratio
dc.subjectN3
dc.subjectPrognosis
dc.titlePrognostic Significance of Metastatic Lymph Node Ratio in Patients with pN3 Gastric Cancer Who Underwent Curative Gastrectomy.
dc.typeArticle
dc.identifier.wosWOS:000464383800005
dc.identifier.scopus85063342267
dc.identifier.doi10.1159/000496746
dc.identifier.pubmed30870846
local.publication.isinternational1
dc.contributor.institutionauthorŞEKER, Mesut


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