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Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary.

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dc.contributor.authorSOYMAN, Z
dc.contributor.authorKELEKCI, S
dc.contributor.authorSAL, V
dc.contributor.authorŞevket, OSMAN
dc.contributor.authorBAYıNDıR, NİHAN
dc.contributor.authorUZUN, H
dc.contributor.institutionauthorŞEVKET, OSMAN
dc.contributor.institutionauthorBAYINDIR, NİHAN
dc.date.accessioned2019-10-05T21:25:42Z
dc.date.available2019-10-05T21:25:42Z
dc.date.issued2017-09-29
dc.description.abstractBackground: Apigenin is a plant-derived compound belonging to the flavone class, which possess antioxidant, free-radical-scavenging and anti-inflammatory properties. Aims: To address the effects of apigenin on serum anti-mullerian hormone levels, tissue oxidative stress parameters and histopathological changes in ovarian ischemia/reperfusion injury. Study design: Animal experiment. Methods: Twenty-eight female Wistar albino rats were randomly separated into four sections: Sham operation (group 1), ischemia/reperfusion plus saline (group 2), ischemia/reperfusion plus dimethyl sulfoxide (group 3) and ischemia/reperfusion plus apigenin (group 4). In all ischemia/reperfusion groups, a bilateral adnexal 3-h period of ischemia was performed, followed by 3-h of reperfusion. A single dose of 15 mg/kg apigenin was given intraperitoneally 60 min before reperfusion in group 4. After 3-h of reperfusion, both ovaries were removed, and blood samples were collected. The main outcome measures were serum anti-mullerian hormone levels, ovarian tissue malondialdehyde, total nitric oxide, Cu/Zn superoxide dismutase, catalase and glutathione levels and histopathological damage scores. Results: The ovarian tissue nitric oxide level was significantly lower, and the glutathione level was significantly higher in group 4 compared with groups 2 and 3. There was no significant difference in anti-mullerian hormone levels among the three ischemia/reperfusion groups. The histopathological damage score was lower in group 4 than in groups 2 and 3 (p>0.05). Conclusion: Administration of apigenin has no significant protective effect on ovarian reserve and tissue damage in ovarian ischemia/reperfusion injury.en
dc.identifier10.1016/0168-8227(93)90113-j
dc.identifier.citationSOYMAN Z., KELEKCI S., SAL V., Şevket O., BAYıNDıR N., UZUN H., -Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary.-, Balkan medical journal, cilt.34, ss.444-449, 2017
dc.identifier.pubmed28443590
dc.identifier.trdizinISSN: 2146-3123 / 2146-3131
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7273
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleEffects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameDIABETES RESEARCH AND CLINICAL PRACTICE
local.avesis.idb537449b-01e3-4698-9303-2539407ccc0a
local.avesis.response7149
relation.isAuthorOfPublicationeb8392bc-16a3-4ddb-b3d1-08d16af341ec
relation.isAuthorOfPublication3c2743d0-b951-4eb5-bdd8-1c932e717700
relation.isAuthorOfPublication.latestForDiscovery3c2743d0-b951-4eb5-bdd8-1c932e717700
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