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Gut bacteria after recovery from COVID-19: a pilot study

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dc.contributor.authorPolo P. G.
dc.contributor.authorAL B. Ç.
dc.contributor.authorŞENTÜRK H.
dc.contributor.authorRAFIQI A. M.
dc.contributor.institutionauthorAL, BİRGÜL ÇOLAK
dc.contributor.institutionauthorŞENTÜRK, HAKAN
dc.contributor.institutionauthorRAFIQI, ABDUL MATTEEN
dc.date.accessioned2023-12-15T21:50:38Z
dc.date.available2023-12-15T21:50:38Z
dc.date.issued2022-01-01
dc.description.abstractOBJECTIVE: COVID-19 has been a major infectious disease lately in hu-mans. 10% of people experience persistent symptoms twelve weeks after having COVID-19. The gut microbiota is essential for host immunity. Thus, gut microbiota composition may contribute to the recovery of COVID-19 patients. The impact of COVID-19 on the gut microbiota of patients during recovery is less explored. We investigated the potential alterations of bacterial gut microbiota of immediately recovered COVID-19 patients, and six months after their recovery. MATERIALS AND METHODS: Stool samples were collected from 8 patients with COVID-19 immediately after their recovery, and six months after SARS-CoV-2 clearance, as well as from 8 healthy donors as a control group. 16S rRNA gene sequencing was performed to analyze the correlation between disease recovery and microbiota using the immediately recovered and control group. Specific primers were designed for the most significantly altered bacteria and used to analyze the changes in intestinal mi-crobiota composition of patients using qPCR. qPCR comparisons were performed on three groups: newly recovered from COVID-19, after six months of COVID-19 recovery, and healthy controls.RESULTS: Compared with the healthy con-trol group, patients who immediately recovered from COVID-19 had significantly less presence of 15 bacterial groups. The immediately recovered patients had a very significantly higher relative abundance of the opportunistic pathogen Mycolicibacterium. No differences were found between the immediately recovered patients, and after six months of recovery using the qP-CR analyses.CONCLUSIONS: Our results contribute novel insights regarding the alteration of human gut microbiota and the emergence of opportunistic pathogens in recovered patients of COVID-19. Further studies with a larger experimental size are needed to reveal balance or dysbiosis in patients after COVID-19 recovery.
dc.identifier.citationPolo P. G., AL B. Ç., ŞENTÜRK H., RAFIQI A. M., "Gut bacteria after recovery from COVID-19: a pilot study", EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.26, sa.22, ss.8599-8611, 2022
dc.identifier.doi10.26355/eurrev_202211_30397
dc.identifier.endpage8611
dc.identifier.issn1128-3602
dc.identifier.issue22
dc.identifier.pubmed36459041
dc.identifier.scopus85143278599
dc.identifier.startpage8599
dc.identifier.urihttps://hdl.handle.net/20.500.12645/38818
dc.identifier.volume26
dc.identifier.wosWOS:000893648700042
dc.relation.ispartofEUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectPharmacology and Therapeutics
dc.subjectBasic Pharmaceutics Sciences
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectFarmakoloji
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectİlaç Rehberleri
dc.subjectPharmacy
dc.subjectPharmacology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectDrug Guides
dc.titleGut bacteria after recovery from COVID-19: a pilot study
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication26922074-0902-4e56-894c-ae91ffff58aa
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relation.isAuthorOfPublication.latestForDiscovery26922074-0902-4e56-894c-ae91ffff58aa
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