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Cyst Fluid Carcinoembryonic Antigen Level Difference between Mucinous Cystic Neoplasms and Intraductal Papillary Mucinous Neoplasms.

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dc.contributor.authorKöker, İbrahim Hakkı
dc.contributor.authorÜnver, Nurcan
dc.contributor.authorMalya, Fatma Ümit
dc.contributor.authorUysal, Ömer
dc.contributor.authorKeskin, Elmas Biberci
dc.contributor.authorŞentürk, Hakan
dc.contributor.institutionauthorMALYA, FATMA ÜMİT
dc.contributor.institutionauthorUYSAL, ÖMER
dc.contributor.institutionauthorBİBERCİ KESKİN, ELMAS
dc.contributor.institutionauthorŞENTÜRK, HAKAN
dc.date.accessioned2020-12-21T20:59:45Z
dc.date.available2020-12-21T20:59:45Z
dc.date.issued2020-12-11T00:00:00Z
dc.description.abstractBackground/aims: The role of cyst fluid carcinoembryonic antigen (CEA) level in differentiating mucinous pancreatic cystic lesions (PCLs) is controversial. We investigated the role of cyst fluid CEA in differentiating low-risk (LR)-intraductal papillary mucinous neoplasms (IPMNs) from high-risk (HR)-IPMNs and LR-mucinous cystic neoplasms (MCNs). Methods: This was a retrospective study of 466 patients with PCLs who underwent endoscopic ultrasound-guided fine-needleaspiration over a 7-year period. On histology, low-grade dysplasia and intermediate-grade dysplasia were considered LR, whereas high-grade dysplasia and invasive carcinoma were considered HR. Results: Data on cyst fluid CEA levels were available for 50/102 mucinous PCLs with definitive diagnoses. The median CEA (range) levels were significantly higher in HR cysts than in LR cysts (2,624 [0.5-266,510] ng/mL vs. 100 [16.8-53,445]ng/mL, p=0.0012). The area under the receiver operating characteristic curve (AUROC) was 0.930 (95% confidence interval [CI], 0.5-0.8; p<0.001) for differentiating LR-IPMNs from LR-MCNs. The AUROC was 0.921 (95% CI, 0.823-1.000; p<0.001) for differentiating LR-IPMNs from HR-IPMNs. Both had a CEA cutoff level of >100ng/mL, with a negative predictive value (NPV) of 100%. Conclusion: Cyst fluid CEA levels significantly vary between LR-IPMNs, LR-MCNs, and HR-IPMNs. A CEA cutoff level of >100ng/mL had a 100% NPV in differentiating LR-IPMNs from LR-MCNs and HR-IPMNs.
dc.identifier.doi10.5946/ce.2020.083
dc.identifier.pubmed33302330
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27779
dc.identifier.wos000614098400021
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCarcinoembryonic antigen
dc.subjectMalignancy
dc.subjectPancreatic cysts
dc.titleCyst Fluid Carcinoembryonic Antigen Level Difference between Mucinous Cystic Neoplasms and Intraductal Papillary Mucinous Neoplasms.
dc.typeArticle
dspace.entity.typePublication
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local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery278fcf63-3b92-4368-bff6-f140ebd9aeb3
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