Publication:
Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms

Simple item page
dc.contributor.authorOnal, Cem
dc.contributor.authorDİNCEL, DEMET
dc.contributor.institutionauthorDİNCEL, DEMET
dc.date.accessioned2021-03-16T20:59:26Z
dc.date.available2021-03-16T20:59:26Z
dc.date.issued2021-03-01T00:00:00Z
dc.description.abstractAbstract Objective: Two simple, rapid and sensitive methods were developed for determination of Erdosteine (ERD) in pure form as well as in their pharmaceutical formulations. Methods: The methods were based on formation of colored charge transfer complexes with ERD with chloranil (CA) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). The obtained charge-transfer complexes were measured at 454 and 843 nm for CA and TCNQ methods, respectively. Optimization of different experimental conditions were investigated. Results: Beer's plots were obeyed in a general concentration range of 10-500 mu g mL(-1) and 20-600 mu g mL(-1) for CA and TCNQ methods, respectively. The validity of methods in terms of specificity, linearity, accuracy, precision, limit of detection and limit of quantitation were evaluated. Conclusion: The methods were applied successfully in the determination of ERD in capsule dosage forms. Developed new spectrophotometric methods have been found to be very practical and practical. The lack of complex sample preparation increases the applicability of the method.
dc.identifier.citationÖnal C, Dinçel D. Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms. Bezmialem Science 2021;9(1):20-4.
dc.identifier.doi10.14235/bas.galenos.2020.3916
dc.identifier.trdizin425309
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28597
dc.identifier.wosWOS:000613760800005
dc.subjectErdosteine
dc.subjectcharge transfer complex
dc.subjectTCNQ
dc.subjectCA
dc.subjectspectrophotometrY
dc.subjectvalidation
dc.subjectpharmaceutical formulation
dc.titleSpectrophotometric Determination of Erdosteine at Capsule Dosage Forms
dc.typeArticle
dspace.entity.typePublication
local.avesis.iddb7ae0d1-17e6-4356-9dc0-bd65c4072d0f
local.publication.isinternational1
relation.isAuthorOfPublication175ac1d2-5098-48b0-b640-bc5d436ea25c
relation.isAuthorOfPublication.latestForDiscovery175ac1d2-5098-48b0-b640-bc5d436ea25c
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms.pdf
Size:
413.39 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Bezmialem Science Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu