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Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors.

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dc.contributor.authorDEMIR, K
dc.contributor.authorAkdemir, ATİLLA
dc.contributor.authorANGELI, A
dc.contributor.authorGÜZEL-AKDEMIR, Ö
dc.contributor.authorSUPURAN, CT
dc.contributor.institutionauthorAKDEMİR, ATİLLA
dc.date.accessioned2019-10-05T21:16:02Z
dc.date.available2019-10-05T21:16:02Z
dc.date.issued2018-12-01
dc.description.abstractA small collection of 26 structurally novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group, were synthesised and tested in enzyme inhibition assays against the tumour-associated hCA IX enzyme. Inhibition constants in the lower micromolar region (KI < 25 lM) have been measured for 17 of the 26 compounds. Even though the KI values are relatively weak, the fact that they do not contain a sulphonamide moiety suggests that these compounds do not interact with the active site zinc ion. Therefore, docking studies and molecular dynamics simulations have been performed to suggest binding poses for these structurally novel inhibitors.en
dc.identifier10.1016/j.clinbiochem.2006.10.006
dc.identifier.citationGÜZEL-AKDEMIR Ö., ANGELI A., DEMIR K., SUPURAN C., Akdemir A., -Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors.-, Journal of enzyme inhibition and medicinal chemistry, cilt.33, ss.1299-1308, 2018
dc.identifier.pubmed30249139
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6917
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleNovel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameCLINICAL BIOCHEMISTRY
local.avesis.idacacf978-51af-4e84-b8b4-b9386ab33aa1
local.avesis.response6793
relation.isAuthorOfPublication19bc513a-c695-4e72-ba1d-83b8d6c574c8
relation.isAuthorOfPublication.latestForDiscovery19bc513a-c695-4e72-ba1d-83b8d6c574c8
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