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The changes of oxidative stress markers and vitamin E in patients with diabetes using SGLT2 inhibitors

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2023-01-01

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Buyukaydin B.
ÖZER Ö. F.
ÖZDER A.
YILDIZ C.

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Abstract

Objectives: This study aimed to research the diversities of vitamin E and oxidative stress parameters related to sodium-glucose transport protein 2 (SGLT2) inhibitor use by type 2 diabetes mellitus (T2DM) patients. Methods: This observational clinical study collected data from 67 T2DM patients (55.7±9.3 years, 46% female). Vitamin E, total oxidant status (TOS), total antioxidant status (TAS), total thiol, native thiol, myeloperoxidase, and catalase levels were evaluated. The TOS/TAS ratio was calculated as the oxidative stress index. Correlations of the parameters to each other and differences based on SGLT2 inhibitor use were recorded. Results: The mean hemoglobin A1c was 7.1 (5.5–13.1). SGLT2 inhibitors (all combinations) were used by 25 patients (37.3%). The mean level of vitamin E was 6 (3.6–9.8) mg/L. There was a positive correlation between vitamin E and low-density lipoprotein cholesterol (p<0.001). While there was no significant correlation between vitamin E and all included oxidative stress parameters, the level of vitamin E was statistically lower in patients using pioglitazone (p=0.036) and statins (p<0.001). In patients using SGLT2 inhibitors, fasting glucose, triglycerides, alanine aminotransferase, and the spot urine protein/creatinine ratio were significantly lower, and the mean TAS was higher (p<0.05). Conclusion: While no differences were observed in vitamin E and other oxidative parameters related to SGLT2 inhibitor use, the increase in TAS provides motivation for further research investigating the antioxidant properties of these inhibitors.

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Yaşam Bilimleri, Biyoteknoloji, Moleküler Biyoloji ve Genetik, Sitogenetik, Temel Bilimler, Life Sciences, Biotechnology, Molecular Biology and Genetics, Cytogenetic, Natural Sciences, Yaşam Bilimleri (LIFE), Mikrobiyoloji, BİYOKİMYA VE MOLEKÜLER BİYOLOJİ, BİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ, Life Sciences (LIFE), MOLECULAR BIOLOGY & GENETICS, MICROBIOLOGY, BIOCHEMISTRY & MOLECULAR BIOLOGY, BIOTECHNOLOGY & APPLIED MICROBIOLOGY, Biyokimya, Biyokimya, Genetik ve Moleküler Biyoloji (çeşitli), Kanser Araştırmaları, Biochemistry, Biochemistry, Genetics and Molecular Biology (miscellaneous), Cancer Research, Oxidative stress, sodium-glucose transport protein 2 inhibitors, type 2 diabetes, vitamin E

Citation

Buyukaydin B., ÖZER Ö. F., ÖZDER A., YILDIZ C., "The changes of oxidative stress markers and vitamin E in patients with diabetes using SGLT2 inhibitors", International Journal of Medical Biochemistry, cilt.6, sa.3, ss.185-190, 2023
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