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Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS

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dc.contributor.authorKızıltaş, Hatice
dc.contributor.authorGÖREN, AHMET CEYHAN
dc.contributor.authorBingol, Zeynebe
dc.contributor.authorAlwasel, Saleh H.
dc.contributor.authorGÜLÇİN, İlhami
dc.contributor.institutionauthorGÖREN, AHMET CEYHAN
dc.date.accessioned2021-06-21T20:59:07Z
dc.date.available2021-06-21T20:59:07Z
dc.date.issued2021-11-01T00:00:00Z
dc.description.abstractTo evaluate the antioxidant activity of evaporated ethanolic extract of Ferula orientalis L. (EEFO) and lyophilized water extract of Ferula orientalis L. (WEFO) several in vitro antioxidant methods such as ABTS(center dot+) scavenging activity, DPPH. scavenging activity, Fe(3+)reduction method, cupric ions (Cu2+) reduction capacity, and metal ion (Fe2+)-binding activities using ferrozine reagent were separately performed. Also, BHT, alpha-tocopherol and ascorbic acid were used as the standard antioxidant molecules. Moreover, some phenolic compounds that are responsible for antioxidant abilities of EEFO and WEFO were determined by LC-HRMS. EEFO and WEFO demonstrated effective antioxidant abilities when compared with the standards. EEFO demonstrated IC50 values of 1.946 mu g/mL against acetylcholinesterase (AChE), 0.815 mu g/mL against alpha-glycosidase, and 0.675 mu g/mL against alpha-amylase.
dc.identifier.citationKızıltaş H., GÖREN A. C. , Bingol Z., Alwasel S. H. , GÜLÇİN İ., -Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS-, RECORDS OF NATURAL PRODUCTS, cilt.15, sa.6, ss.513-528, 2021
dc.identifier.doi10.25135/rnp.236.21.02.1983
dc.identifier.trdizinISSN: 1307-6167
dc.identifier.trdizinISSN: 1307-6167
dc.identifier.trdizintrdizin
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28994
dc.identifier.wosWOS:000658306500008
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleAnticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS
dc.typeArticle
dspace.entity.typePublication
local.avesis.idbd9883b8-6958-4c83-88cf-7e437513ba24
local.publication.isinternational1
relation.isAuthorOfPublication07fcea81-8515-4cd4-86f2-047fe6b2df71
relation.isAuthorOfPublication.latestForDiscovery07fcea81-8515-4cd4-86f2-047fe6b2df71
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