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A class of sulfonamides as carbonic anhydrase I and II inhibitors

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dc.contributor.authorGOKCEN, Taner
dc.contributor.authorGÜLÇİN, İlhami
dc.contributor.authorOZTURK, Turan
dc.contributor.authorGoren, AHMET CEYHAN
dc.contributor.institutionauthorGÖREN, AHMET CEYHAN
dc.date.accessioned2020-10-29T21:35:13Z
dc.date.available2020-10-29T21:35:13Z
dc.date.issued2016-12-01T00:00:00Z
dc.description.abstractFour groups of novel sulfonamide derivatives: (i) acetoxybenzamide, (ii) triacetoxybenzamide, (iii) hydroxybenzamide and (iv) trihydroxybenzamide, all having thiazole, pyrimidine, pyridine, isoxazole and thiadiazole moieties were prepared and their inhibitory effects were studied on two metalloenzymes, i.e. carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-l-tyrosine-sulfanilamide affinity chromatography. These enzymes are present in almost all living organisms to catalyse the synthesis of bicarbonate ion (HCO3-) from carbon dioxide and water. The sulfonamide derivatives were found to be active against hCA I and II in the range of 2.62-136.54 and 5.74-210.58nM, respectively.
dc.identifier.citationGOKCEN T., GÜLÇİN İ., OZTURK T., Goren A. C. , -A class of sulfonamides as carbonic anhydrase I and II inhibitors-, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.31, ss.180-188, 2016
dc.identifier.doi10.1080/14756366.2016.1198900
dc.identifier.scopus84976394880
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26334
dc.identifier.wosWOS:000390410800021
dc.titleA class of sulfonamides as carbonic anhydrase I and II inhibitors
dc.typeArticle
dspace.entity.typePublication
local.avesis.id9186d801-a9e3-4064-85bd-ffbae62af7fe
local.publication.isinternational1
relation.isAuthorOfPublication07fcea81-8515-4cd4-86f2-047fe6b2df71
relation.isAuthorOfPublication.latestForDiscovery07fcea81-8515-4cd4-86f2-047fe6b2df71
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