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The impact of hydroxychloroquine-azithromycin combination on Tpeak-to-end and Tpeak-to-end/QT ratio during a short treatment course

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dc.contributor.authorBAKHSALIYEV, NIJAD
dc.contributor.authorÖZDEMİR, Ramazan
dc.contributor.institutionauthorBAKHSALIYEV, NIJAD
dc.contributor.institutionauthorÖZDEMİR, RAMAZAN
dc.date.accessioned2021-05-18T20:59:15Z
dc.date.available2021-05-18T20:59:15Z
dc.date.issued2021-05-01T00:00:00Z
dc.description.abstractBackground: Since there was no proven treatment of coronavirus disease 2019 (COVID-19), hydroxychloroquine-azithromycin (HCQ-AZM) combination is being used in different countries as a treatment option. Many controversies exist related to the safety and effectiveness of this combination, and questions about how HCQ-AZM combination affects the ventricular repolarization are still unknown. Objective: The aim of the study was to show whether the hydroxychloroquine-azithromycin (HCQ-AZM) combination prolonged Tpeak-to-end (TpTe) duration and TpTe/QT interval ratio or not. Methods: One hundred and twenty-six consequent COVID-19(+) patients meeting the study criteria were enrolled in this study. Baseline ECGs were obtained immediately after hospitalization and before commencing the HCQ-AZM combination. On-treatment ECG was obtained 24-48 hr after the loading dose of HCQ/AZM. ECG parameters including PR interval, QRS duration, QT interval, QTc interval, TpTe duration, and TpTe/QT interval ratio were assessed. Demographic and laboratory findings were collected from an electronic recording system. Results: ECGs of 126 COVID-19(+) patients who received HCQ-AZM combination were assessed. Mean baseline QTc (by Fridericia formula), TpTe, and TpTe/QT ratio were 420.0 ± 26.5 ms, 82.43 ± 9.77 ms, and 0.22 ± 0.02, respectively. On-treatment QTc, TpTe and TpTe/QT ratio were 425.7 ± 27.18 ms, 85.17 ± 11.17 ms, and 0.22 ± 0.03, respectively. No statistically significant acute impacts of HCQ-AZM combination on TpTe duration and TpTe/QT interval ratio were observed compared with baseline values. No ventricular tachycardia/fibrillation and the significant conduction delays were seen during in-hospital follow-up. Conclusion: HCQ-AZM combination increased TpTe duration. However, no significant impact on TpTe/QT interval ratio was observed.
dc.identifier.citationcoronavirus disease 2019
dc.identifier.doi10.1111/anec.12846
dc.identifier.pubmed33956361
dc.identifier.scopus85105236844
dc.identifier.trdizintrdizin
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28900
dc.identifier.wosWOS:000647584900001
dc.subjectTpeak-to-end
dc.subjectazithromycin
dc.subjectcardiac death
dc.subjectelectrocardiography
dc.subjecthydroxychloroquine
dc.titleThe impact of hydroxychloroquine-azithromycin combination on Tpeak-to-end and Tpeak-to-end/QT ratio during a short treatment course
dc.typeArticle
dspace.entity.typePublication
local.avesis.idc00fc473-f0b2-4ad5-9dbb-e6f21798ce20
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublicationd09a7383-b5b4-4454-aed7-bfa2b095b670
relation.isAuthorOfPublication6384fc88-e60f-4402-bacf-1f1b2120fb58
relation.isAuthorOfPublication.latestForDiscovery6384fc88-e60f-4402-bacf-1f1b2120fb58
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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