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A novel tool reflecting the role of oxidative stress in the cataracts: thiol/disulfide homeostasis

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dc.contributor.authorElbay, AHMET
dc.contributor.authorOzer, Omer Faruk
dc.contributor.authorALTINISIK, Muhammed
dc.contributor.authorELBAY, Arif Emre
dc.contributor.authorSezer, TAHA
dc.contributor.authorBayraktar, HAVVANUR
dc.contributor.authorOZDEMIR, Hakan
dc.contributor.institutionauthorELBAY, AHMET
dc.contributor.institutionauthorÖZER, ÖMER FARUK
dc.contributor.institutionauthorSEZER, TAHA
dc.contributor.institutionauthorBAYRAKTAR, HAVVANUR
dc.contributor.institutionauthorÖZDEMİR, MEHMET HAKAN
dc.date.accessioned2019-10-05T21:35:06Z
dc.date.available2019-10-05T21:35:06Z
dc.date.issued2017-01-01
dc.description.abstractWe investigated serum and aqueous humor thiol/disulfide (T-D) homeostasis in patients with cataracts versus healthy controls. In total, 56 patients with cataracts and 49 healthy controls were enrolled in this case-control study. Serum total thiol (TT), native thiol (NT), and disulfide (DS) concentrations were determined using a novel automated measurement method. Additionally, DS/TT, DS/NT and NT/TT percentage ratios were compared between the groups. In comparison with the control group, serum NT levels and aqueous humor TT and NT levels were significantly lower (p<.05, p<.05 and p<.001, respectively), whereas serum and aqueous humor DS levels were significantly higher in cataract patients (p<.01 and p<.001). DS/TT and DS/NT ratios were significantly higher and the NT/TT ratio was lower in cataract patients in serum (p<.005) and aqueous humor samples (p<.001). In conclusion, serum T-D homeostasis may be useful as biochemical markers, indicating the role of oxidative stress in the development of cataracts. Further studies are needed to confirm the pathophysiological role of T-D homeostasis in cataractogenesis.
dc.identifier10.1016/j.phytol.2011.05.002
dc.identifier.citationElbay A., Ozer O. F. , ALTINISIK M., ELBAY A. E. , Sezer T., Bayraktar H., OZDEMIR H., -A novel tool reflecting the role of oxidative stress in the cataracts: thiol/disulfide homeostasis-, SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, cilt.77, ss.223-227, 2017
dc.identifier.pubmed28276726
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7679
dc.language.isoen
dc.titleA novel tool reflecting the role of oxidative stress in the cataracts: thiol/disulfide homeostasis
dc.typeArticle
dspace.entity.typePublication
local.article.journalnamePHYTOCHEMISTRY LETTERS
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local.avesis.response7555
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relation.isAuthorOfPublication.latestForDiscovery62494279-0a51-4ce5-82bf-526629b906ac
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